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Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting

Artificial intelligence of things (AIoT) has become a potential tool for use in a wide range of fields, and its use is expanding in interdisciplinary sciences. On the other hand, in a clinical scenario, human blood-clotting disease (Royal disease) detection has been considered an urgent issue that h...

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Main Authors: Gopinath, Subash C. B., Ismail, Zool Hilmi, Shapiai, Mohd. Ibrahim, Mohd. Sobran, Nur Maisarah
Format: Article
Published: John Wiley and Sons Inc 2022
Subjects:
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/101265/
http://dx.doi.org/10.1002/bab.2164
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spelling my.utm.1012652023-06-08T08:19:26Z http://eprints.utm.my/id/eprint/101265/ Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting Gopinath, Subash C. B. Ismail, Zool Hilmi Shapiai, Mohd. Ibrahim Mohd. Sobran, Nur Maisarah T Technology (General) Artificial intelligence of things (AIoT) has become a potential tool for use in a wide range of fields, and its use is expanding in interdisciplinary sciences. On the other hand, in a clinical scenario, human blood-clotting disease (Royal disease) detection has been considered an urgent issue that has to be solved. This study uses AIoT with deep long short-term memory networks for biosensing application and analyzes the potent clinical target, human blood clotting factor IX, by its aptamer/antibody as the probe on the microscaled fingers and gaps of the interdigitated electrode. The earlier results by the current–volt measurements have shown the changes in the surface modification. The limit of detection (LOD) was noticed as 1 pM with the antibody as the probe, whereas the aptamer behaved better with the LOD at 100 fM. The time-series predictions from the AIoT application supported the obtained results with the laboratory analyses using both probes. This application clearly supports the results obtained from the interdigitated electrode sensor as aptamer to be the better option for analyzing the blood clotting defects. The current study supports a great implementation of AIoT in sensing application and can be followed for other clinical biomarkers. John Wiley and Sons Inc 2022 Article PeerReviewed Gopinath, Subash C. B. and Ismail, Zool Hilmi and Shapiai, Mohd. Ibrahim and Mohd. Sobran, Nur Maisarah (2022) Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting. Biotechnology and Applied Biochemistry, 69 (3). pp. 930-938. ISSN 0885-4513 http://dx.doi.org/10.1002/bab.2164 DOI : 10.1002/bab.2164
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic T Technology (General)
spellingShingle T Technology (General)
Gopinath, Subash C. B.
Ismail, Zool Hilmi
Shapiai, Mohd. Ibrahim
Mohd. Sobran, Nur Maisarah
Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting
description Artificial intelligence of things (AIoT) has become a potential tool for use in a wide range of fields, and its use is expanding in interdisciplinary sciences. On the other hand, in a clinical scenario, human blood-clotting disease (Royal disease) detection has been considered an urgent issue that has to be solved. This study uses AIoT with deep long short-term memory networks for biosensing application and analyzes the potent clinical target, human blood clotting factor IX, by its aptamer/antibody as the probe on the microscaled fingers and gaps of the interdigitated electrode. The earlier results by the current–volt measurements have shown the changes in the surface modification. The limit of detection (LOD) was noticed as 1 pM with the antibody as the probe, whereas the aptamer behaved better with the LOD at 100 fM. The time-series predictions from the AIoT application supported the obtained results with the laboratory analyses using both probes. This application clearly supports the results obtained from the interdigitated electrode sensor as aptamer to be the better option for analyzing the blood clotting defects. The current study supports a great implementation of AIoT in sensing application and can be followed for other clinical biomarkers.
format Article
author Gopinath, Subash C. B.
Ismail, Zool Hilmi
Shapiai, Mohd. Ibrahim
Mohd. Sobran, Nur Maisarah
author_facet Gopinath, Subash C. B.
Ismail, Zool Hilmi
Shapiai, Mohd. Ibrahim
Mohd. Sobran, Nur Maisarah
author_sort Gopinath, Subash C. B.
title Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting
title_short Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting
title_full Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting
title_fullStr Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting
title_full_unstemmed Biosensing human blood clotting factor by dual probes: Evaluation by deep long short-term memory networks in time series forecasting
title_sort biosensing human blood clotting factor by dual probes: evaluation by deep long short-term memory networks in time series forecasting
publisher John Wiley and Sons Inc
publishDate 2022
url http://eprints.utm.my/id/eprint/101265/
http://dx.doi.org/10.1002/bab.2164
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score 13.211869

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