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Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior

It is very desirable to have good antibacterial properties and mechanical properties at the same time for bone scaffolds. Graphene oxide (GO) can increase the mechanical properties and antibacterial performance, while forsterite (Mg2SiO4) as the matrix can increase forsterite/GO scaffolds' biol...

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Main Authors:	Najafinezhad, A., Bakhsheshi-Rad, H. R., Saberi, A., Nourbakhsh, A. A., Daroonparvar, M., Ismail, Ahmad Fauzi, Sharif, Safian, RamaKrishna, Seeram, Dai, Yunqian, Berto, F.
Format:	Article
Published:	Institute of Physics 2022
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/101225/ http://dx.doi.org/10.1088/1748-605X/ac62e8
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spelling	my.utm.1012252023-06-01T10:00:15Z http://eprints.utm.my/id/eprint/101225/ Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior Najafinezhad, A. Bakhsheshi-Rad, H. R. Saberi, A. Nourbakhsh, A. A. Daroonparvar, M. Ismail, Ahmad Fauzi Sharif, Safian RamaKrishna, Seeram Dai, Yunqian Berto, F. TP Chemical technology It is very desirable to have good antibacterial properties and mechanical properties at the same time for bone scaffolds. Graphene oxide (GO) can increase the mechanical properties and antibacterial performance, while forsterite (Mg2SiO4) as the matrix can increase forsterite/GO scaffolds' biological activity for bone tissue engineering. Interconnected porous forsterite scaffolds were developed by space holder processes for bone tissue engineering in this research. The forsterite/GO scaffolds had a porosity of 76%-78% with pore size of 300-450 µm. The mechanism of the mechanical strengthening, antibacterial activity, and cellular function of the forsterite/GO scaffold was evaluated. The findings show that the compressive strength of forsterite/1 wt.% GO scaffold (2.4 ± 0.1 MPa) was significantly increased, in comparison to forsterite scaffolds without GO (1.4 ± 0.1 MPa). Validation of the samples' bioactivity was attained by forming a hydroxyapatite layer on the forsterite/GO surface within in vitro immersion test. The results of cell viability demonstrated that synthesized forsterite scaffolds with low GO did not show cytotoxicity and enhanced cell proliferation. Antibacterial tests showed that the antibacterial influence of forsterite/GO scaffold was strongly correlated with GO concentration from 0.5 to 2 wt.%. The scaffold encapsulated with 2 wt.% GO had the great antibacterial performance with bacterial inhibition rate around 90%. As results show, the produced forsterite/1 wt.% GO can be an attractive option for bone tissue engineering. Institute of Physics 2022 Article PeerReviewed Najafinezhad, A. and Bakhsheshi-Rad, H. R. and Saberi, A. and Nourbakhsh, A. A. and Daroonparvar, M. and Ismail, Ahmad Fauzi and Sharif, Safian and RamaKrishna, Seeram and Dai, Yunqian and Berto, F. (2022) Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior. Biomedical Materials (Bristol), 17 (3). ISSN 1748-6041 http://dx.doi.org/10.1088/1748-605X/ac62e8 DOI : 10.1088/1748-605X/ac62e8
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	TP Chemical technology
spellingShingle	TP Chemical technology Najafinezhad, A. Bakhsheshi-Rad, H. R. Saberi, A. Nourbakhsh, A. A. Daroonparvar, M. Ismail, Ahmad Fauzi Sharif, Safian RamaKrishna, Seeram Dai, Yunqian Berto, F. Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior
description	It is very desirable to have good antibacterial properties and mechanical properties at the same time for bone scaffolds. Graphene oxide (GO) can increase the mechanical properties and antibacterial performance, while forsterite (Mg2SiO4) as the matrix can increase forsterite/GO scaffolds' biological activity for bone tissue engineering. Interconnected porous forsterite scaffolds were developed by space holder processes for bone tissue engineering in this research. The forsterite/GO scaffolds had a porosity of 76%-78% with pore size of 300-450 µm. The mechanism of the mechanical strengthening, antibacterial activity, and cellular function of the forsterite/GO scaffold was evaluated. The findings show that the compressive strength of forsterite/1 wt.% GO scaffold (2.4 ± 0.1 MPa) was significantly increased, in comparison to forsterite scaffolds without GO (1.4 ± 0.1 MPa). Validation of the samples' bioactivity was attained by forming a hydroxyapatite layer on the forsterite/GO surface within in vitro immersion test. The results of cell viability demonstrated that synthesized forsterite scaffolds with low GO did not show cytotoxicity and enhanced cell proliferation. Antibacterial tests showed that the antibacterial influence of forsterite/GO scaffold was strongly correlated with GO concentration from 0.5 to 2 wt.%. The scaffold encapsulated with 2 wt.% GO had the great antibacterial performance with bacterial inhibition rate around 90%. As results show, the produced forsterite/1 wt.% GO can be an attractive option for bone tissue engineering.
format	Article
author	Najafinezhad, A. Bakhsheshi-Rad, H. R. Saberi, A. Nourbakhsh, A. A. Daroonparvar, M. Ismail, Ahmad Fauzi Sharif, Safian RamaKrishna, Seeram Dai, Yunqian Berto, F.
author_facet	Najafinezhad, A. Bakhsheshi-Rad, H. R. Saberi, A. Nourbakhsh, A. A. Daroonparvar, M. Ismail, Ahmad Fauzi Sharif, Safian RamaKrishna, Seeram Dai, Yunqian Berto, F.
author_sort	Najafinezhad, A.
title	Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior
title_short	Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior
title_full	Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior
title_fullStr	Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior
title_full_unstemmed	Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior
title_sort	graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior
publisher	Institute of Physics
publishDate	2022
url	http://eprints.utm.my/id/eprint/101225/ http://dx.doi.org/10.1088/1748-605X/ac62e8
_version_	1768006626813411328
score	13.211869

Graphene oxide encapsulated forsterite scaffolds to improve mechanical properties and antibacterial behavior

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