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Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery

Male pattern baldness (MPB) is a common condition that has a negative impact on the psycho-social health of many men. This study aims to engineer an alcohol-free formulation to cater for individuals who may have had allergic reactions to alcohol-based preparations. A lipidbased nanoparticle system c...

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Main Authors: Mohamed Noor, Norhayati, Umar, Sana, Abdul-Aziz, Azila, Sheikh, Khalid, Somavarapu, Satyanarayana
Format: Article
Language:English
Published: MDPI 2022
Subjects:
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/101195/1/AzilaAbdulAziz2022_EngineeredDutasterideLipidBasedNanoparticle.pdf
http://eprints.utm.my/id/eprint/101195/
http://dx.doi.org/10.3390/bioengineering9010011
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spelling my.utm.1011952023-06-01T09:41:32Z http://eprints.utm.my/id/eprint/101195/ Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery Mohamed Noor, Norhayati Umar, Sana Abdul-Aziz, Azila Sheikh, Khalid Somavarapu, Satyanarayana T Technology (General) Male pattern baldness (MPB) is a common condition that has a negative impact on the psycho-social health of many men. This study aims to engineer an alcohol-free formulation to cater for individuals who may have had allergic reactions to alcohol-based preparations. A lipidbased nanoparticle system composed of stearic and oleic acid (solid and liquid lipid) was used to deliver dutasteride (DST) for topical application. Two compositions, with oleic acid (Formulation A) and without (Formulation B), were compared to analyse the role of oleic acid as a potential active ingredient in addition to DST. DST-loaded LNP were prepared using the emulsification– ultrasonication method. All of the prepared formulations were spherical in shape in the nanometric size range (150–300 nm), with entrapment efficiencies of >75%. X-ray diffractograms revealed that DST exists in an amorphous form within the NLP matrices. The drug release behaviour from both LNP preparations displayed slow release of DST. Permeation studies through pig ear skin demonstrated that DST-LNP with oleic acid produced significantly lower permeation into the dermis compared to the formulation without oleic acid. These results suggest that the proposed formulation presents several characteristics which are novel, indicating its suitability for the dermal delivery of anti-androgenic molecules. MDPI 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/101195/1/AzilaAbdulAziz2022_EngineeredDutasterideLipidBasedNanoparticle.pdf Mohamed Noor, Norhayati and Umar, Sana and Abdul-Aziz, Azila and Sheikh, Khalid and Somavarapu, Satyanarayana (2022) Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery. Bioengineering, 9 (1). pp. 1-11. ISSN 2306-5354 http://dx.doi.org/10.3390/bioengineering9010011 DOI : 10.3390/bioengineering9010011
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic T Technology (General)
spellingShingle T Technology (General)
Mohamed Noor, Norhayati
Umar, Sana
Abdul-Aziz, Azila
Sheikh, Khalid
Somavarapu, Satyanarayana
Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery
description Male pattern baldness (MPB) is a common condition that has a negative impact on the psycho-social health of many men. This study aims to engineer an alcohol-free formulation to cater for individuals who may have had allergic reactions to alcohol-based preparations. A lipidbased nanoparticle system composed of stearic and oleic acid (solid and liquid lipid) was used to deliver dutasteride (DST) for topical application. Two compositions, with oleic acid (Formulation A) and without (Formulation B), were compared to analyse the role of oleic acid as a potential active ingredient in addition to DST. DST-loaded LNP were prepared using the emulsification– ultrasonication method. All of the prepared formulations were spherical in shape in the nanometric size range (150–300 nm), with entrapment efficiencies of >75%. X-ray diffractograms revealed that DST exists in an amorphous form within the NLP matrices. The drug release behaviour from both LNP preparations displayed slow release of DST. Permeation studies through pig ear skin demonstrated that DST-LNP with oleic acid produced significantly lower permeation into the dermis compared to the formulation without oleic acid. These results suggest that the proposed formulation presents several characteristics which are novel, indicating its suitability for the dermal delivery of anti-androgenic molecules.
format Article
author Mohamed Noor, Norhayati
Umar, Sana
Abdul-Aziz, Azila
Sheikh, Khalid
Somavarapu, Satyanarayana
author_facet Mohamed Noor, Norhayati
Umar, Sana
Abdul-Aziz, Azila
Sheikh, Khalid
Somavarapu, Satyanarayana
author_sort Mohamed Noor, Norhayati
title Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery
title_short Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery
title_full Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery
title_fullStr Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery
title_full_unstemmed Engineered dutasteride-lipid based nanoparticle (DST-LNP) system using oleic and stearic acid for topical delivery
title_sort engineered dutasteride-lipid based nanoparticle (dst-lnp) system using oleic and stearic acid for topical delivery
publisher MDPI
publishDate 2022
url http://eprints.utm.my/id/eprint/101195/1/AzilaAbdulAziz2022_EngineeredDutasterideLipidBasedNanoparticle.pdf
http://eprints.utm.my/id/eprint/101195/
http://dx.doi.org/10.3390/bioengineering9010011
_version_ 1768006622594990080
score 13.211869

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