Staff View: Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment

Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment

Wound dressing have experienced continuous improvement and changes since ancient time. Electrospinning of polymeric nanofibers have captured the interest of researchers due to its simplicity and cost effective technique that able to produce wound dressing membrane that meet the requirement as ideal...

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Main Authors:	Ng, Celine, Hamzah, Mohd Syahir Anwar, Abd Razak, Saiful Izwan, Abdul Sukor, Jumadi, Nayan, Nafarizal, Mat Nayan, Nadirul Hasraf
Format:	Article
Language:	English
Published:	UTHM Publishing 2020
Subjects:	R855-855.5 Medical technology TP1080-1185 Polymers and polymer manufacture
Online Access:	http://eprints.uthm.edu.my/6427/1/AJ%202020%20%28866%29.pdf http://eprints.uthm.edu.my/6427/ https://doi.org/10.30880/jaita.2020.01.02.002
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spelling	my.uthm.eprints.64272022-01-30T08:54:28Z http://eprints.uthm.edu.my/6427/ Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment Ng, Celine Hamzah, Mohd Syahir Anwar Abd Razak, Saiful Izwan Abdul Sukor, Jumadi Nayan, Nafarizal Mat Nayan, Nadirul Hasraf R855-855.5 Medical technology TP1080-1185 Polymers and polymer manufacture Wound dressing have experienced continuous improvement and changes since ancient time. Electrospinning of polymeric nanofibers have captured the interest of researchers due to its simplicity and cost effective technique that able to produce wound dressing membrane that meet the requirement as ideal wound dressing and drug delivery carrier. In this work, polyvinyl alcohol (PVA) and poly (lactic acid) (PLA) were chosen polymer to produce wound dressing membrane through electrospinning and coating method. PVA was electrospun and then coated with PLA. Preliminary study had been conducted between 1, 4 and 8% concentration for the selection of optimum PLA coating concentration. PLA has been proposed for the use of coating materials at 4%, the coated nanofiber membrane started to exhibit high Ultimate Tensile Strength at 1022.5 ± 9.28 MPa, highest degree of swelling (1850 ± 3.7 %) and optimum water contact angle (60.9 ± 11.46 ̊). The aim of this study was to investigate the morphological properties of PVA/PLA wound dressing membrane. Based on the results from Atomic Force Microscope, PVA nanofiber coated with 4% PLA exhibit the highest value of Rq which is 0.47 ± 0.19 μm compared to neat PVA nanofibers membrane. Field Emission Scanning Electron Microscope (FE-SEM) image revealed that PVA nanofiber coated with 4% PLA shows porous fiber-like morphology and well incorporated with each other without any gap formed between them. This report clearly suggestive of the fact that synthetic biodegradable polymers such as PLA can be exploited for the synergistic combination with PVA nanofiber for wound dressing application. UTHM Publishing 2020 Article PeerReviewed text en http://eprints.uthm.edu.my/6427/1/AJ%202020%20%28866%29.pdf Ng, Celine and Hamzah, Mohd Syahir Anwar and Abd Razak, Saiful Izwan and Abdul Sukor, Jumadi and Nayan, Nafarizal and Mat Nayan, Nadirul Hasraf (2020) Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment. Journal of Advanced Industrial Technology and Application, 1 (2). pp. 7-11. ISSN 2716-7097 https://doi.org/10.30880/jaita.2020.01.02.002
institution	Universiti Tun Hussein Onn Malaysia
building	UTHM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tun Hussein Onn Malaysia
content_source	UTHM Institutional Repository
url_provider	http://eprints.uthm.edu.my/
language	English
topic	R855-855.5 Medical technology TP1080-1185 Polymers and polymer manufacture
spellingShingle	R855-855.5 Medical technology TP1080-1185 Polymers and polymer manufacture Ng, Celine Hamzah, Mohd Syahir Anwar Abd Razak, Saiful Izwan Abdul Sukor, Jumadi Nayan, Nafarizal Mat Nayan, Nadirul Hasraf Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment
description	Wound dressing have experienced continuous improvement and changes since ancient time. Electrospinning of polymeric nanofibers have captured the interest of researchers due to its simplicity and cost effective technique that able to produce wound dressing membrane that meet the requirement as ideal wound dressing and drug delivery carrier. In this work, polyvinyl alcohol (PVA) and poly (lactic acid) (PLA) were chosen polymer to produce wound dressing membrane through electrospinning and coating method. PVA was electrospun and then coated with PLA. Preliminary study had been conducted between 1, 4 and 8% concentration for the selection of optimum PLA coating concentration. PLA has been proposed for the use of coating materials at 4%, the coated nanofiber membrane started to exhibit high Ultimate Tensile Strength at 1022.5 ± 9.28 MPa, highest degree of swelling (1850 ± 3.7 %) and optimum water contact angle (60.9 ± 11.46 ̊). The aim of this study was to investigate the morphological properties of PVA/PLA wound dressing membrane. Based on the results from Atomic Force Microscope, PVA nanofiber coated with 4% PLA exhibit the highest value of Rq which is 0.47 ± 0.19 μm compared to neat PVA nanofibers membrane. Field Emission Scanning Electron Microscope (FE-SEM) image revealed that PVA nanofiber coated with 4% PLA shows porous fiber-like morphology and well incorporated with each other without any gap formed between them. This report clearly suggestive of the fact that synthetic biodegradable polymers such as PLA can be exploited for the synergistic combination with PVA nanofiber for wound dressing application.
format	Article
author	Ng, Celine Hamzah, Mohd Syahir Anwar Abd Razak, Saiful Izwan Abdul Sukor, Jumadi Nayan, Nafarizal Mat Nayan, Nadirul Hasraf
author_facet	Ng, Celine Hamzah, Mohd Syahir Anwar Abd Razak, Saiful Izwan Abdul Sukor, Jumadi Nayan, Nafarizal Mat Nayan, Nadirul Hasraf
author_sort	Ng, Celine
title	Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment
title_short	Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment
title_full	Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment
title_fullStr	Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment
title_full_unstemmed	Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment
title_sort	study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment
publisher	UTHM Publishing
publishDate	2020
url	http://eprints.uthm.edu.my/6427/1/AJ%202020%20%28866%29.pdf http://eprints.uthm.edu.my/6427/ https://doi.org/10.30880/jaita.2020.01.02.002
_version_	1738581491518013440
score	13.211869

Study on morphological properties of polyvinyl alcohol/poly(lactic acid) wound dressing membrane as drug delivery carrier in wound healing treatment

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