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Voltage clamp simulations of cardiac excitation: FPGA implementation

This paper presents the simulation study of voltage clamp technique that enables to analyse current-voltage (I-V) characteristics of ion currents based on Luo-Rudy Phase-I (LR-I) model by using a Field Programmable Gate Array (FPGA). Here, the I-V relationship presents the characterization of each i...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Mahmud, Farhanahani, Mahamad, Abd Kadir, Jabbar, M. Hairol, Othman, Norliza, Adon, Nur Atiqah
التنسيق: مقال
اللغة:English
منشور في: Asian Research Publishing Network (ARPN) 2016
الموضوعات:
TK7800-8360 Electronics
الوصول للمادة أونلاين:http://eprints.uthm.edu.my/4294/1/AJ%202016%20%2833%29.pdf
http://eprints.uthm.edu.my/4294/
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id my.uthm.eprints.4294
record_format eprints
spelling my.uthm.eprints.42942021-12-02T02:29:14Z http://eprints.uthm.edu.my/4294/ Voltage clamp simulations of cardiac excitation: FPGA implementation Mahmud, Farhanahani Mahamad, Abd Kadir Jabbar, M. Hairol Othman, Norliza Adon, Nur Atiqah TK7800-8360 Electronics This paper presents the simulation study of voltage clamp technique that enables to analyse current-voltage (I-V) characteristics of ion currents based on Luo-Rudy Phase-I (LR-I) model by using a Field Programmable Gate Array (FPGA). Here, the I-V relationship presents the characterization of each ion channel by a relation between membrane voltage, Vm and resulting channel current. In addition, the voltage clamp technique also allows the detection of single channel currents in biological membranes and is known to be applicable in identifying variety of electrophysiological problems in the cellular level. As computational simulations devote a vast amount of time to run due to the increasing complexity of cardiac models, a real-time hardware implementation using FPGA could be the solution as it provides high configurability and performance, and able to executes in parallel mode operation for high-performance real-time systems. For shorter time development while retaining high confidence results, FPGA-based rapid prototyping through HDL Coder from MATLAB software has been used to construct the algorithm for the simulation system. Basically, the HDL Coder is capable to convert the designed MATLAB Simulink blocks into hardware description language (HDL) for the FPGA implementation. As a result, the MATLAB Simulink successfully simulates the voltage clamp of the LR-I excitation model and identifies the I-V characteristics of the ionic currents through Xilinx Virtex-6 XC6VLX240T development board. Asian Research Publishing Network (ARPN) 2016 Article PeerReviewed text en http://eprints.uthm.edu.my/4294/1/AJ%202016%20%2833%29.pdf Mahmud, Farhanahani and Mahamad, Abd Kadir and Jabbar, M. Hairol and Othman, Norliza and Adon, Nur Atiqah (2016) Voltage clamp simulations of cardiac excitation: FPGA implementation. ARPN Journal of Engineering and Applied Sciences, 11 (24). pp. 14056-14064. ISSN 1819-6608
institution Universiti Tun Hussein Onn Malaysia
building UTHM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tun Hussein Onn Malaysia
content_source UTHM Institutional Repository
url_provider http://eprints.uthm.edu.my/
language English
topic TK7800-8360 Electronics
spellingShingle TK7800-8360 Electronics
Mahmud, Farhanahani
Mahamad, Abd Kadir
Jabbar, M. Hairol
Othman, Norliza
Adon, Nur Atiqah
Voltage clamp simulations of cardiac excitation: FPGA implementation
description This paper presents the simulation study of voltage clamp technique that enables to analyse current-voltage (I-V) characteristics of ion currents based on Luo-Rudy Phase-I (LR-I) model by using a Field Programmable Gate Array (FPGA). Here, the I-V relationship presents the characterization of each ion channel by a relation between membrane voltage, Vm and resulting channel current. In addition, the voltage clamp technique also allows the detection of single channel currents in biological membranes and is known to be applicable in identifying variety of electrophysiological problems in the cellular level. As computational simulations devote a vast amount of time to run due to the increasing complexity of cardiac models, a real-time hardware implementation using FPGA could be the solution as it provides high configurability and performance, and able to executes in parallel mode operation for high-performance real-time systems. For shorter time development while retaining high confidence results, FPGA-based rapid prototyping through HDL Coder from MATLAB software has been used to construct the algorithm for the simulation system. Basically, the HDL Coder is capable to convert the designed MATLAB Simulink blocks into hardware description language (HDL) for the FPGA implementation. As a result, the MATLAB Simulink successfully simulates the voltage clamp of the LR-I excitation model and identifies the I-V characteristics of the ionic currents through Xilinx Virtex-6 XC6VLX240T development board.
format Article
author Mahmud, Farhanahani
Mahamad, Abd Kadir
Jabbar, M. Hairol
Othman, Norliza
Adon, Nur Atiqah
author_facet Mahmud, Farhanahani
Mahamad, Abd Kadir
Jabbar, M. Hairol
Othman, Norliza
Adon, Nur Atiqah
author_sort Mahmud, Farhanahani
title Voltage clamp simulations of cardiac excitation: FPGA implementation
title_short Voltage clamp simulations of cardiac excitation: FPGA implementation
title_full Voltage clamp simulations of cardiac excitation: FPGA implementation
title_fullStr Voltage clamp simulations of cardiac excitation: FPGA implementation
title_full_unstemmed Voltage clamp simulations of cardiac excitation: FPGA implementation
title_sort voltage clamp simulations of cardiac excitation: fpga implementation
publisher Asian Research Publishing Network (ARPN)
publishDate 2016
url http://eprints.uthm.edu.my/4294/1/AJ%202016%20%2833%29.pdf
http://eprints.uthm.edu.my/4294/
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score 13.251813

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