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Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques

The interaction of green zinc oxide nanoparticles (ZnO NPs) with bacterial strains are still scarcely reported. This work was conducted to study the green-one-pot-synthesized ZnO NPs from the Aloe Vulgarize (AV) leaf peel extract assisted with different sonication techniques followed by the physicoc...

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Main Authors: Dzulkharnien, Nur Syafiqah Farhanah, Rohani, Rosiah, Tan Kofli, Noorhisham, Mohd Kasim, Noor Alicezah, Abd. Muid, Suhaila, Patrick, Melonney, Mohd Fauzi, Noor Akhmazillah, Alias, Hajar, Radzuan, Husna Ahmad
Format: Article
Language:English
Published: elsevier 2024
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TP Chemical technology
Online Access:http://eprints.uthm.edu.my/12504/1/J17994_605283e6fb2104f40bfa85b8bf4fa7dd.pdf
http://eprints.uthm.edu.my/12504/
https://doi.org/10.1016/j.bioorg.2024.107513
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spelling my.uthm.eprints.125042025-02-24T07:47:20Z http://eprints.uthm.edu.my/12504/ Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques Dzulkharnien, Nur Syafiqah Farhanah Rohani, Rosiah Tan Kofli, Noorhisham Mohd Kasim, Noor Alicezah Abd. Muid, Suhaila Patrick, Melonney Mohd Fauzi, Noor Akhmazillah Alias, Hajar Radzuan, Husna Ahmad TP Chemical technology The interaction of green zinc oxide nanoparticles (ZnO NPs) with bacterial strains are still scarcely reported. This work was conducted to study the green-one-pot-synthesized ZnO NPs from the Aloe Vulgarize (AV) leaf peel extract assisted with different sonication techniques followed by the physicochemical, biological activities and molecular docking studies. The NPs structure was analyzed using FTIR, UV–vis and EDX. The morphology, particle size and crystallinity of ZnO NPs were identified using FESEM and XRD. It was found that the formed flower-like structure with sharp edge and fine size of particulates in ZnO NPs/AV could enhance the bacterial inhibition. The minimum inhibitory concentration (MIC) for all the tested bacterial strains is at 3.125 µg/ml and the bacterial growth curve are dependent on the ZnO NPs dosage. The results of disc diffusion revealed that the ZnO NPs/AV possess better antibacterial effect with bigger ZOI due to the presence of AV active ingredient. The molecular docking between active ingredients of AV in the NPs with the protein of IFCM and 1MWU revealed that low binding energy (Ebind = -6.56 kcal/mol and − 8.99 kcal/mol, respectively) attributes to the excessive hydrogen bond from AV that highly influenced their interaction with the amino acid of the selected proteins. Finally, the cytotoxicity test on the biosynthesized ZnO NPs with concentration below 20 µg/ml are found nontoxic on the HDF cell. Overall, ZnO NPs/20 % AV (probe sonication) is considered as the best synthesis option due to its efficient one-pot method, short sonication time but own the best antibacterial effect. elsevier 2024 Article PeerReviewed text en http://eprints.uthm.edu.my/12504/1/J17994_605283e6fb2104f40bfa85b8bf4fa7dd.pdf Dzulkharnien, Nur Syafiqah Farhanah and Rohani, Rosiah and Tan Kofli, Noorhisham and Mohd Kasim, Noor Alicezah and Abd. Muid, Suhaila and Patrick, Melonney and Mohd Fauzi, Noor Akhmazillah and Alias, Hajar and Radzuan, Husna Ahmad (2024) Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques. Bioorganic Chemistry, 150. pp. 1-20. https://doi.org/10.1016/j.bioorg.2024.107513
institution Universiti Tun Hussein Onn Malaysia
building UTHM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tun Hussein Onn Malaysia
content_source UTHM Institutional Repository
url_provider http://eprints.uthm.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Dzulkharnien, Nur Syafiqah Farhanah
Rohani, Rosiah
Tan Kofli, Noorhisham
Mohd Kasim, Noor Alicezah
Abd. Muid, Suhaila
Patrick, Melonney
Mohd Fauzi, Noor Akhmazillah
Alias, Hajar
Radzuan, Husna Ahmad
Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques
description The interaction of green zinc oxide nanoparticles (ZnO NPs) with bacterial strains are still scarcely reported. This work was conducted to study the green-one-pot-synthesized ZnO NPs from the Aloe Vulgarize (AV) leaf peel extract assisted with different sonication techniques followed by the physicochemical, biological activities and molecular docking studies. The NPs structure was analyzed using FTIR, UV–vis and EDX. The morphology, particle size and crystallinity of ZnO NPs were identified using FESEM and XRD. It was found that the formed flower-like structure with sharp edge and fine size of particulates in ZnO NPs/AV could enhance the bacterial inhibition. The minimum inhibitory concentration (MIC) for all the tested bacterial strains is at 3.125 µg/ml and the bacterial growth curve are dependent on the ZnO NPs dosage. The results of disc diffusion revealed that the ZnO NPs/AV possess better antibacterial effect with bigger ZOI due to the presence of AV active ingredient. The molecular docking between active ingredients of AV in the NPs with the protein of IFCM and 1MWU revealed that low binding energy (Ebind = -6.56 kcal/mol and − 8.99 kcal/mol, respectively) attributes to the excessive hydrogen bond from AV that highly influenced their interaction with the amino acid of the selected proteins. Finally, the cytotoxicity test on the biosynthesized ZnO NPs with concentration below 20 µg/ml are found nontoxic on the HDF cell. Overall, ZnO NPs/20 % AV (probe sonication) is considered as the best synthesis option due to its efficient one-pot method, short sonication time but own the best antibacterial effect.
format Article
author Dzulkharnien, Nur Syafiqah Farhanah
Rohani, Rosiah
Tan Kofli, Noorhisham
Mohd Kasim, Noor Alicezah
Abd. Muid, Suhaila
Patrick, Melonney
Mohd Fauzi, Noor Akhmazillah
Alias, Hajar
Radzuan, Husna Ahmad
author_facet Dzulkharnien, Nur Syafiqah Farhanah
Rohani, Rosiah
Tan Kofli, Noorhisham
Mohd Kasim, Noor Alicezah
Abd. Muid, Suhaila
Patrick, Melonney
Mohd Fauzi, Noor Akhmazillah
Alias, Hajar
Radzuan, Husna Ahmad
author_sort Dzulkharnien, Nur Syafiqah Farhanah
title Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques
title_short Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques
title_full Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques
title_fullStr Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques
title_full_unstemmed Enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with Aloe Vulgarize through one-pot ultrasonication techniques
title_sort enhanced binding interaction and antibacterial inhibition for nanometal oxide particles activated with aloe vulgarize through one-pot ultrasonication techniques
publisher elsevier
publishDate 2024
url http://eprints.uthm.edu.my/12504/1/J17994_605283e6fb2104f40bfa85b8bf4fa7dd.pdf
http://eprints.uthm.edu.my/12504/
https://doi.org/10.1016/j.bioorg.2024.107513
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score 13.244413

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