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Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption

Paracetamol, a popular analgesic, has been linked to harmful health effects, such as kidney and liver damage. The detection of paracetamol in the environment and its overdose use in humans and animals has raised global concerns, highlighting the need for its efficient removal or detection in real s...

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Main Authors: Asman, Saliza, Mohd Idris, Alya Athirah, Sambasevam, Kavirajaa Pandian
Format: Article
Language:English
Published: elsevier 2024
Subjects:
QD Chemistry
Online Access:http://eprints.uthm.edu.my/12497/1/J17983_d94a9b0c638c96f6f74496c4896d0a0c.pdf
http://eprints.uthm.edu.my/12497/
https://doi.org/10.1016/j.molliq.2024.125365
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spelling my.uthm.eprints.124972025-02-24T07:57:30Z http://eprints.uthm.edu.my/12497/ Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption Asman, Saliza Mohd Idris, Alya Athirah Sambasevam, Kavirajaa Pandian QD Chemistry Paracetamol, a popular analgesic, has been linked to harmful health effects, such as kidney and liver damage. The detection of paracetamol in the environment and its overdose use in humans and animals has raised global concerns, highlighting the need for its efficient removal or detection in real samples. In this study, a deep eutectic solvent-molecularly imprinted polymer (DES-MIP) was synthesized and applied as an adsorbent to recognize the removal of paracetamol selectively. DES-MIP was synthesized using a deep eutectic solvent (DES) as a functional monomer, ethylene glycol dimethacrylate as a crosslinker, and paracetamol as a template. DES was initially prepared by combining choline chloride (ChCl) with methacrylic acid at a molar ratio of 1:2. A deep eutectic solvent-non-imprinted polymer (DES-NIP) was synthesized as a control. The characterization analysis, including Fourier transform infrared spectroscopy (FTIR), Scanning emission microscopy (SEM), and Brunauer-EmmettTeller (BET) was conducted for both polymers to confirm the synthesis occurred. The selectivity study inferred that DES-MIP (15.95 mg/g) was more selective towards paracetamol than DES-NIP (7.00 mg/g). Response surface methodology (RSM) coupled with central composite design (CCD) was employed to examine the effect of pH, contact time, and dosage on paracetamol adsorption. The analysis of variance (ANOVA) demonstrated the relative significance of process parameters in the adsorption process. The contact time and dosage were found to be more significant than the pH. The result indicated that the optimal conditions for paracetamol adsorption were pH 7, 35 min, and 5.5 mg. The behavior of paracetamol adsorption on DES-MIP was well-fitted using the second-order kinetic and Langmuir isothermal models, respectively. Then, the DES-MIP with optimized parameter studies was applied to herbs, medicine, and dietary supplements, achieving good recoveries of 94.46 %, 86.79 %, and 85.13 % and relative standard deviations (RSD) of 1.15 %, 2.39 %, and 2.52 %, respectively. elsevier 2024 Article PeerReviewed text en http://eprints.uthm.edu.my/12497/1/J17983_d94a9b0c638c96f6f74496c4896d0a0c.pdf Asman, Saliza and Mohd Idris, Alya Athirah and Sambasevam, Kavirajaa Pandian (2024) Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption. Journal of Molecular Liquids, 408. pp. 1-16. https://doi.org/10.1016/j.molliq.2024.125365
institution Universiti Tun Hussein Onn Malaysia
building UTHM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tun Hussein Onn Malaysia
content_source UTHM Institutional Repository
url_provider http://eprints.uthm.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Asman, Saliza
Mohd Idris, Alya Athirah
Sambasevam, Kavirajaa Pandian
Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption
description Paracetamol, a popular analgesic, has been linked to harmful health effects, such as kidney and liver damage. The detection of paracetamol in the environment and its overdose use in humans and animals has raised global concerns, highlighting the need for its efficient removal or detection in real samples. In this study, a deep eutectic solvent-molecularly imprinted polymer (DES-MIP) was synthesized and applied as an adsorbent to recognize the removal of paracetamol selectively. DES-MIP was synthesized using a deep eutectic solvent (DES) as a functional monomer, ethylene glycol dimethacrylate as a crosslinker, and paracetamol as a template. DES was initially prepared by combining choline chloride (ChCl) with methacrylic acid at a molar ratio of 1:2. A deep eutectic solvent-non-imprinted polymer (DES-NIP) was synthesized as a control. The characterization analysis, including Fourier transform infrared spectroscopy (FTIR), Scanning emission microscopy (SEM), and Brunauer-EmmettTeller (BET) was conducted for both polymers to confirm the synthesis occurred. The selectivity study inferred that DES-MIP (15.95 mg/g) was more selective towards paracetamol than DES-NIP (7.00 mg/g). Response surface methodology (RSM) coupled with central composite design (CCD) was employed to examine the effect of pH, contact time, and dosage on paracetamol adsorption. The analysis of variance (ANOVA) demonstrated the relative significance of process parameters in the adsorption process. The contact time and dosage were found to be more significant than the pH. The result indicated that the optimal conditions for paracetamol adsorption were pH 7, 35 min, and 5.5 mg. The behavior of paracetamol adsorption on DES-MIP was well-fitted using the second-order kinetic and Langmuir isothermal models, respectively. Then, the DES-MIP with optimized parameter studies was applied to herbs, medicine, and dietary supplements, achieving good recoveries of 94.46 %, 86.79 %, and 85.13 % and relative standard deviations (RSD) of 1.15 %, 2.39 %, and 2.52 %, respectively.
format Article
author Asman, Saliza
Mohd Idris, Alya Athirah
Sambasevam, Kavirajaa Pandian
author_facet Asman, Saliza
Mohd Idris, Alya Athirah
Sambasevam, Kavirajaa Pandian
author_sort Asman, Saliza
title Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption
title_short Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption
title_full Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption
title_fullStr Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption
title_full_unstemmed Molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption
title_sort molecularly imprinted polymer based on deep eutectic solvent as functional monomer for paracetamol adsorption
publisher elsevier
publishDate 2024
url http://eprints.uthm.edu.my/12497/1/J17983_d94a9b0c638c96f6f74496c4896d0a0c.pdf
http://eprints.uthm.edu.my/12497/
https://doi.org/10.1016/j.molliq.2024.125365
_version_ 1825163117658636288
score 13.244413

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