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A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications

Background: Derived from Garcinia plants, garcinol has gained prominence for its versatile health benefits, ranging from antioxidant and anti-inflammatory properties to immunomodulation and anticancer effects. Notably, there is a growing interest in exploring its potential against obesity and relate...

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Main Author:	Abu Bakar, Mohd Fadzelly
Format:	Article
Language:	English
Published:	Elsevier 2024
Subjects:	TA Engineering (General). Civil engineering (General)
Online Access:	http://eprints.uthm.edu.my/12427/1/J17912_1bc71c9b399f32f051164749f9d793ba.pdf http://eprints.uthm.edu.my/12427/ https://doi.org/10.1016/j.phanu.2024.100388
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spelling	my.uthm.eprints.124272025-01-31T08:33:50Z http://eprints.uthm.edu.my/12427/ A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications Abu Bakar, Mohd Fadzelly TA Engineering (General). Civil engineering (General) Background: Derived from Garcinia plants, garcinol has gained prominence for its versatile health benefits, ranging from antioxidant and anti-inflammatory properties to immunomodulation and anticancer effects. Notably, there is a growing interest in exploring its potential against obesity and related disorders. While hydroxycitric acid (HCA) has been linked to the anti-obesity effects of certain Garcinia fruits, recent research emphasizes the role of garcinol, either alone or in combination, in mediating these effects. Methods: The review was conducted using the databases Medline, Scopus, Web of Science, and Google Scholar. The search was performed using the keywords ’obesity’, ’overweight’, ’garcinol’, ’in vitro’, ’in vivo’ and ’clinical studies.’ Discussions focused on the effect of garcinol on body weight, obesity and its related complications. Results: The findings revealed that garcinol, distinct from HCA, plays a central role in anti-obesity effects. Inhibiting fatty acid synthase emerged as a key mechanism, disrupting fatty acid synthesis and facilitating weight control. Garcinol demonstrated effectiveness in appetite suppression, fat reduction, modulation of obesity-related factors, and metabolic enhancement, collectively contributing to weight loss. Furthermore, the study established the bioavailability, pharmacokinetics, and biodistribution of garcinol, underscoring its anti-inflammatory properties as valuable in addressing obesity-associated inflammation. Conclusion: While promising indications from cell, animal, and preliminary clinical studies highlight garcinol’s anti-obesity potential, it is crucial to acknowledge that research in this domain is still in its early stages. To conclusively establish the effectiveness and safety of garcinol as an anti-obesity treatment, comprehensive studies, particularly involving human subjects, are imperative Elsevier 2024 Article PeerReviewed text en http://eprints.uthm.edu.my/12427/1/J17912_1bc71c9b399f32f051164749f9d793ba.pdf Abu Bakar, Mohd Fadzelly (2024) A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications. PharmaNutrition, 28. pp. 1-12. https://doi.org/10.1016/j.phanu.2024.100388
institution	Universiti Tun Hussein Onn Malaysia
building	UTHM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tun Hussein Onn Malaysia
content_source	UTHM Institutional Repository
url_provider	http://eprints.uthm.edu.my/
language	English
topic	TA Engineering (General). Civil engineering (General)
spellingShingle	TA Engineering (General). Civil engineering (General) Abu Bakar, Mohd Fadzelly A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications
description	Background: Derived from Garcinia plants, garcinol has gained prominence for its versatile health benefits, ranging from antioxidant and anti-inflammatory properties to immunomodulation and anticancer effects. Notably, there is a growing interest in exploring its potential against obesity and related disorders. While hydroxycitric acid (HCA) has been linked to the anti-obesity effects of certain Garcinia fruits, recent research emphasizes the role of garcinol, either alone or in combination, in mediating these effects. Methods: The review was conducted using the databases Medline, Scopus, Web of Science, and Google Scholar. The search was performed using the keywords ’obesity’, ’overweight’, ’garcinol’, ’in vitro’, ’in vivo’ and ’clinical studies.’ Discussions focused on the effect of garcinol on body weight, obesity and its related complications. Results: The findings revealed that garcinol, distinct from HCA, plays a central role in anti-obesity effects. Inhibiting fatty acid synthase emerged as a key mechanism, disrupting fatty acid synthesis and facilitating weight control. Garcinol demonstrated effectiveness in appetite suppression, fat reduction, modulation of obesity-related factors, and metabolic enhancement, collectively contributing to weight loss. Furthermore, the study established the bioavailability, pharmacokinetics, and biodistribution of garcinol, underscoring its anti-inflammatory properties as valuable in addressing obesity-associated inflammation. Conclusion: While promising indications from cell, animal, and preliminary clinical studies highlight garcinol’s anti-obesity potential, it is crucial to acknowledge that research in this domain is still in its early stages. To conclusively establish the effectiveness and safety of garcinol as an anti-obesity treatment, comprehensive studies, particularly involving human subjects, are imperative
format	Article
author	Abu Bakar, Mohd Fadzelly
author_facet	Abu Bakar, Mohd Fadzelly
author_sort	Abu Bakar, Mohd Fadzelly
title	A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications
title_short	A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications
title_full	A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications
title_fullStr	A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications
title_full_unstemmed	A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications
title_sort	multi-targeted approach of garcinol for obesity intervention: mechanistic insights and possible clinical applications
publisher	Elsevier
publishDate	2024
url	http://eprints.uthm.edu.my/12427/1/J17912_1bc71c9b399f32f051164749f9d793ba.pdf http://eprints.uthm.edu.my/12427/ https://doi.org/10.1016/j.phanu.2024.100388
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score	13.244413

A multi-targeted approach of garcinol for obesity intervention: Mechanistic insights and possible clinical applications

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