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Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells

Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran...

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Main Authors: Wijianto, Diski Wahyu, Sri Wahyuni, Arifah, Wardani, Rizkiananda, Nugraheni, Ambar Yunita, Abu Bakar, Fazleen Izzany
Format: Article
Language:English
Published: 2024
Subjects:
RM Therapeutics. Pharmacology
Online Access:http://eprints.uthm.edu.my/11980/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf
http://eprints.uthm.edu.my/11980/
https://doi.org/10.36721/PJPS.2024.37.2.REG.
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spelling my.uthm.eprints.119802025-01-21T00:41:41Z http://eprints.uthm.edu.my/11980/ Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells Wijianto, Diski Wahyu Sri Wahyuni, Arifah Wardani, Rizkiananda Nugraheni, Ambar Yunita Abu Bakar, Fazleen Izzany RM Therapeutics. Pharmacology Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells. 2024 Article PeerReviewed text en http://eprints.uthm.edu.my/11980/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf Wijianto, Diski Wahyu and Sri Wahyuni, Arifah and Wardani, Rizkiananda and Nugraheni, Ambar Yunita and Abu Bakar, Fazleen Izzany (2024) Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells. -. pp. 307-314. https://doi.org/10.36721/PJPS.2024.37.2.REG.
institution Universiti Tun Hussein Onn Malaysia
building UTHM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tun Hussein Onn Malaysia
content_source UTHM Institutional Repository
url_provider http://eprints.uthm.edu.my/
language English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Wijianto, Diski Wahyu
Sri Wahyuni, Arifah
Wardani, Rizkiananda
Nugraheni, Ambar Yunita
Abu Bakar, Fazleen Izzany
Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
description Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells.
format Article
author Wijianto, Diski Wahyu
Sri Wahyuni, Arifah
Wardani, Rizkiananda
Nugraheni, Ambar Yunita
Abu Bakar, Fazleen Izzany
author_facet Wijianto, Diski Wahyu
Sri Wahyuni, Arifah
Wardani, Rizkiananda
Nugraheni, Ambar Yunita
Abu Bakar, Fazleen Izzany
author_sort Wijianto, Diski Wahyu
title Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_short Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_full Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_fullStr Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_full_unstemmed Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_sort evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
publishDate 2024
url http://eprints.uthm.edu.my/11980/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf
http://eprints.uthm.edu.my/11980/
https://doi.org/10.36721/PJPS.2024.37.2.REG.
_version_ 1823094296310448128
score 13.244413

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