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Control of microstructure architecture of polycaprolactone electrospun scaffolds

Tissue engineering is an area in which new tissues or organs are replicated in a promising way to replace damaged tissues or organs caused by accidents and medical conditions. For cells to grow, a proper environment provided by scaffolds can imitate the composition of that original human extra cellu...

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Main Authors: Rajendran, R., Ham, W. J., Low, C. Y., Alexander, C. H. C., Koh, C. T.
Format: Conference or Workshop Item
Language:English
Published: 2024
Subjects:
QD Chemistry
Online Access:http://eprints.uthm.edu.my/11954/1/Control%20of%20microstructure.pdf
http://eprints.uthm.edu.my/11954/
https://doi.org/10.1063/5.0231402
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spelling my.uthm.eprints.119542025-01-10T07:48:14Z http://eprints.uthm.edu.my/11954/ Control of microstructure architecture of polycaprolactone electrospun scaffolds Rajendran, R. Ham, W. J. Low, C. Y. Alexander, C. H. C. Koh, C. T. QD Chemistry Tissue engineering is an area in which new tissues or organs are replicated in a promising way to replace damaged tissues or organs caused by accidents and medical conditions. For cells to grow, a proper environment provided by scaffolds can imitate the composition of that original human extra cellular matrix (ECM). This study focuses on the preparation of Polycaprolactone (PCL) nanofibers using electrospinning approach. The effect of process parameters such as PCL concentration, flow rate and voltage supply on the architecture of microstructure was also studied. The diameter and porosity of the nanofibers were analyzed from images taken by Scanning Electron Microscopy. Beads were found in the electrospun scaffolds due to high humidity. The beads formation was reduced by adding PBS salt solution and increasing the distance of the collector plate from the needle tip. Further, electrospun nanofibers with larger diameters were by having higher PCL concentration, higher flow rate and lower voltage. This study suggests the importance of the control of humidity and process parameters during process electrospinning in the control of the microstructure of the electrospun scaffolds. 2024-08-30 Conference or Workshop Item PeerReviewed text en http://eprints.uthm.edu.my/11954/1/Control%20of%20microstructure.pdf Rajendran, R. and Ham, W. J. and Low, C. Y. and Alexander, C. H. C. and Koh, C. T. (2024) Control of microstructure architecture of polycaprolactone electrospun scaffolds. In: PROCEEDINGS OF 5TH INTERNATIONAL CONFERENCE ON SUSTAINABLE INNOVATION IN ENGINEERING AND TECHNOLOGY 2023. https://doi.org/10.1063/5.0231402
institution Universiti Tun Hussein Onn Malaysia
building UTHM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tun Hussein Onn Malaysia
content_source UTHM Institutional Repository
url_provider http://eprints.uthm.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Rajendran, R.
Ham, W. J.
Low, C. Y.
Alexander, C. H. C.
Koh, C. T.
Control of microstructure architecture of polycaprolactone electrospun scaffolds
description Tissue engineering is an area in which new tissues or organs are replicated in a promising way to replace damaged tissues or organs caused by accidents and medical conditions. For cells to grow, a proper environment provided by scaffolds can imitate the composition of that original human extra cellular matrix (ECM). This study focuses on the preparation of Polycaprolactone (PCL) nanofibers using electrospinning approach. The effect of process parameters such as PCL concentration, flow rate and voltage supply on the architecture of microstructure was also studied. The diameter and porosity of the nanofibers were analyzed from images taken by Scanning Electron Microscopy. Beads were found in the electrospun scaffolds due to high humidity. The beads formation was reduced by adding PBS salt solution and increasing the distance of the collector plate from the needle tip. Further, electrospun nanofibers with larger diameters were by having higher PCL concentration, higher flow rate and lower voltage. This study suggests the importance of the control of humidity and process parameters during process electrospinning in the control of the microstructure of the electrospun scaffolds.
format Conference or Workshop Item
author Rajendran, R.
Ham, W. J.
Low, C. Y.
Alexander, C. H. C.
Koh, C. T.
author_facet Rajendran, R.
Ham, W. J.
Low, C. Y.
Alexander, C. H. C.
Koh, C. T.
author_sort Rajendran, R.
title Control of microstructure architecture of polycaprolactone electrospun scaffolds
title_short Control of microstructure architecture of polycaprolactone electrospun scaffolds
title_full Control of microstructure architecture of polycaprolactone electrospun scaffolds
title_fullStr Control of microstructure architecture of polycaprolactone electrospun scaffolds
title_full_unstemmed Control of microstructure architecture of polycaprolactone electrospun scaffolds
title_sort control of microstructure architecture of polycaprolactone electrospun scaffolds
publishDate 2024
url http://eprints.uthm.edu.my/11954/1/Control%20of%20microstructure.pdf
http://eprints.uthm.edu.my/11954/
https://doi.org/10.1063/5.0231402
_version_ 1821004332654395392
score 13.244413

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