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Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis

Mangifera rufocostata, a member of the Mangifera genus, is a source of secondary metabolites and has been used traditionally as antidiabetic agent. Therefore, this study aims to determine the total flavonoid contens (TFC), total phenolic contents (TPC), antioxidant, α-glucosidase inhibitory, and cy...

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Main Authors: Mustikasari, Kamilia, Santoso, Mardi, Abu Bakar, Mohd Fadzelly, Sri Fatmawati, Sri Fatmawati
Format: Article
Language:English
Published: 2024
Subjects:
RS153-441 Materia medica
Online Access:http://eprints.uthm.edu.my/11717/1/J16902_cdb733027701d91024b2e466f832c5ac.pdf
http://eprints.uthm.edu.my/11717/
https://doi.org/10.1016/j.arabjc.2023.105391
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spelling my.uthm.eprints.117172024-11-27T06:51:35Z http://eprints.uthm.edu.my/11717/ Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis Mustikasari, Kamilia Santoso, Mardi Abu Bakar, Mohd Fadzelly Sri Fatmawati, Sri Fatmawati RS153-441 Materia medica Mangifera rufocostata, a member of the Mangifera genus, is a source of secondary metabolites and has been used traditionally as antidiabetic agent. Therefore, this study aims to determine the total flavonoid contens (TFC), total phenolic contents (TPC), antioxidant, α-glucosidase inhibitory, and cytotoxic activities of M. rufocostata stem bark extract. Antioxidant activity were evaluated by 2-2″-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and ferric reducing-antioxidant power (FRAP) tests. α-glucosidase inhibitory to prediction antidiabetic activity, and cytotoxic activity were studied against HT-29, HeLa, and MCF-7 cancer cell lines. The results showed that the methanol extract have the highest TFC, TPC, antioxidant, and α-glucosidase inhibitory activity. Furthermore, the methanol extract has strong cytotoxicity againts HT-29 cancer cells. Based on LC-MS/MS, the methanol extract contain several major compounds such as mangiferin, quinic acid, gallic acid, and 3-methoxy-4-hydroxy-phenyl glycol. 2024 Article PeerReviewed text en http://eprints.uthm.edu.my/11717/1/J16902_cdb733027701d91024b2e466f832c5ac.pdf Mustikasari, Kamilia and Santoso, Mardi and Abu Bakar, Mohd Fadzelly and Sri Fatmawati, Sri Fatmawati (2024) Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis. Arabian Journal of Chemistry, 17. https://doi.org/10.1016/j.arabjc.2023.105391
institution Universiti Tun Hussein Onn Malaysia
building UTHM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tun Hussein Onn Malaysia
content_source UTHM Institutional Repository
url_provider http://eprints.uthm.edu.my/
language English
topic RS153-441 Materia medica
spellingShingle RS153-441 Materia medica
Mustikasari, Kamilia
Santoso, Mardi
Abu Bakar, Mohd Fadzelly
Sri Fatmawati, Sri Fatmawati
Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis
description Mangifera rufocostata, a member of the Mangifera genus, is a source of secondary metabolites and has been used traditionally as antidiabetic agent. Therefore, this study aims to determine the total flavonoid contens (TFC), total phenolic contents (TPC), antioxidant, α-glucosidase inhibitory, and cytotoxic activities of M. rufocostata stem bark extract. Antioxidant activity were evaluated by 2-2″-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), and ferric reducing-antioxidant power (FRAP) tests. α-glucosidase inhibitory to prediction antidiabetic activity, and cytotoxic activity were studied against HT-29, HeLa, and MCF-7 cancer cell lines. The results showed that the methanol extract have the highest TFC, TPC, antioxidant, and α-glucosidase inhibitory activity. Furthermore, the methanol extract has strong cytotoxicity againts HT-29 cancer cells. Based on LC-MS/MS, the methanol extract contain several major compounds such as mangiferin, quinic acid, gallic acid, and 3-methoxy-4-hydroxy-phenyl glycol.
format Article
author Mustikasari, Kamilia
Santoso, Mardi
Abu Bakar, Mohd Fadzelly
Sri Fatmawati, Sri Fatmawati
author_facet Mustikasari, Kamilia
Santoso, Mardi
Abu Bakar, Mohd Fadzelly
Sri Fatmawati, Sri Fatmawati
author_sort Mustikasari, Kamilia
title Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis
title_short Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis
title_full Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis
title_fullStr Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis
title_full_unstemmed Antioxidant, α-glucosidase inhibitory, and cytotoxic activities of Mangifera rufocostata extract and identification of its compounds by LC-MS/ MS analysis
title_sort antioxidant, α-glucosidase inhibitory, and cytotoxic activities of mangifera rufocostata extract and identification of its compounds by lc-ms/ ms analysis
publishDate 2024
url http://eprints.uthm.edu.my/11717/1/J16902_cdb733027701d91024b2e466f832c5ac.pdf
http://eprints.uthm.edu.my/11717/
https://doi.org/10.1016/j.arabjc.2023.105391
_version_ 1817845159385104384
score 13.223943

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