Staff View: Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells

Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells

Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran...

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Main Authors:	Diski Wahyu Wijianto, Diski Wahyu Wijianto, Arifah Sri Wahyuni, Arifah Sri Wahyuni, Rizkiananda Wardan, Rizkiananda Wardan, Ambar Yunita Nugraheni, Ambar Yunita Nugraheni, Abu Bakar, Fazleen Izzany
Format:	Article
Language:	English
Published:	2024
Subjects:	T Technology (General)
Online Access:	http://eprints.uthm.edu.my/11125/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf http://eprints.uthm.edu.my/11125/ https://doi.org/10.36721/PJPS.2024.37.2.REG.307-314.1
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id	my.uthm.eprints.11125
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spelling	my.uthm.eprints.111252024-06-10T02:02:21Z http://eprints.uthm.edu.my/11125/ Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany T Technology (General) Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells. 2024 Article PeerReviewed text en http://eprints.uthm.edu.my/11125/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf Diski Wahyu Wijianto, Diski Wahyu Wijianto and Arifah Sri Wahyuni, Arifah Sri Wahyuni and Rizkiananda Wardan, Rizkiananda Wardan and Ambar Yunita Nugraheni, Ambar Yunita Nugraheni and Abu Bakar, Fazleen Izzany (2024) Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells. -. pp. 307-314. https://doi.org/10.36721/PJPS.2024.37.2.REG.307-314.1
institution	Universiti Tun Hussein Onn Malaysia
building	UTHM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tun Hussein Onn Malaysia
content_source	UTHM Institutional Repository
url_provider	http://eprints.uthm.edu.my/
language	English
topic	T Technology (General)
spellingShingle	T Technology (General) Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
description	Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells.
format	Article
author	Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany
author_facet	Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany
author_sort	Diski Wahyu Wijianto, Diski Wahyu Wijianto
title	Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_short	Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_full	Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_fullStr	Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_full_unstemmed	Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
title_sort	evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
publishDate	2024
url	http://eprints.uthm.edu.my/11125/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf http://eprints.uthm.edu.my/11125/ https://doi.org/10.36721/PJPS.2024.37.2.REG.307-314.1
_version_	1803337342797217792
score	13.226443

Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells

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