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In vitro surface efficacy of CaP-based anodised titanium for bone implants

This study examined the effect of changes to the surface of CaP-based anodised titanium on osteogenesis and antimicrobial activity in vitro. The present work is proposed to investigate the mechanical stability of two different CaP/TiO2 micromorphology-based coatings, namely donut-shaped (350 V) and...

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Main Authors:	Alipal, J., Saidin, S., Kai Lo, A.Z., Koshy, P., Abdullah, H.Z., Idris, M.I., Lee, T.C.
Format:	Article
Language:	English
Published:	Elsevier 2023
Subjects:	T Technology (General)
Online Access:	http://eprints.uthm.edu.my/10371/1/J16043_3ebf01813a855fc8bfbea2ea2e595eb8.pdf http://eprints.uthm.edu.my/10371/ https://doi.org/10.1016/j.surfin.2023.102872
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spelling	my.uthm.eprints.103712023-11-21T01:10:50Z http://eprints.uthm.edu.my/10371/ In vitro surface efficacy of CaP-based anodised titanium for bone implants Alipal, J. Saidin, S. Kai Lo, A.Z. Koshy, P. Abdullah, H.Z. Idris, M.I. Lee, T.C. T Technology (General) This study examined the effect of changes to the surface of CaP-based anodised titanium on osteogenesis and antimicrobial activity in vitro. The present work is proposed to investigate the mechanical stability of two different CaP/TiO2 micromorphology-based coatings, namely donut-shaped (350 V) and needle-shaped (450 V), that are fabricated by single-step micro-arc anodic oxidation at different conditions alongside with their cytocompatibility and antibacterial properties. The microhardness of the sample anodised at 450 V is ~100 MPa lower than that seen in the sample fabricated at 350 V, but both resultant coatings were strongly adhere to the substrate. However, the coating at 450 V was observed to suffer from delamination, indicating the needle-like structure is mechanically unstable. After 7 days of SBF immersion, the 450 V sample was highly bioactive relative to the 350 V sample. However, MTT assays showed that the 450 V coatings showed lower growth rate of hFOB 1.19 at day 14, which indicates that although the structure does have a superior ability to form apatite, it has long-term negative implications possibly from the toxicity of the structure to bone growth. The Alizarin-red staining shows that 450 V sample shows a negative trend of osteogenic mineralisation, thus qualitatively validating the toxicity. For antimicrobial effects, the donut-shaped microstructures were shown to have adequate antibacterial properties compared to the needle-like structures. Overall, this study suggest that the donut-shaped TiO2 morphology is the best cementless interface for bone cell anchorage. Elsevier 2023 Article PeerReviewed text en http://eprints.uthm.edu.my/10371/1/J16043_3ebf01813a855fc8bfbea2ea2e595eb8.pdf Alipal, J. and Saidin, S. and Kai Lo, A.Z. and Koshy, P. and Abdullah, H.Z. and Idris, M.I. and Lee, T.C. (2023) In vitro surface efficacy of CaP-based anodised titanium for bone implants. Surfaces and Interfaces, 39. pp. 1-21. https://doi.org/10.1016/j.surfin.2023.102872
institution	Universiti Tun Hussein Onn Malaysia
building	UTHM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tun Hussein Onn Malaysia
content_source	UTHM Institutional Repository
url_provider	http://eprints.uthm.edu.my/
language	English
topic	T Technology (General)
spellingShingle	T Technology (General) Alipal, J. Saidin, S. Kai Lo, A.Z. Koshy, P. Abdullah, H.Z. Idris, M.I. Lee, T.C. In vitro surface efficacy of CaP-based anodised titanium for bone implants
description	This study examined the effect of changes to the surface of CaP-based anodised titanium on osteogenesis and antimicrobial activity in vitro. The present work is proposed to investigate the mechanical stability of two different CaP/TiO2 micromorphology-based coatings, namely donut-shaped (350 V) and needle-shaped (450 V), that are fabricated by single-step micro-arc anodic oxidation at different conditions alongside with their cytocompatibility and antibacterial properties. The microhardness of the sample anodised at 450 V is ~100 MPa lower than that seen in the sample fabricated at 350 V, but both resultant coatings were strongly adhere to the substrate. However, the coating at 450 V was observed to suffer from delamination, indicating the needle-like structure is mechanically unstable. After 7 days of SBF immersion, the 450 V sample was highly bioactive relative to the 350 V sample. However, MTT assays showed that the 450 V coatings showed lower growth rate of hFOB 1.19 at day 14, which indicates that although the structure does have a superior ability to form apatite, it has long-term negative implications possibly from the toxicity of the structure to bone growth. The Alizarin-red staining shows that 450 V sample shows a negative trend of osteogenic mineralisation, thus qualitatively validating the toxicity. For antimicrobial effects, the donut-shaped microstructures were shown to have adequate antibacterial properties compared to the needle-like structures. Overall, this study suggest that the donut-shaped TiO2 morphology is the best cementless interface for bone cell anchorage.
format	Article
author	Alipal, J. Saidin, S. Kai Lo, A.Z. Koshy, P. Abdullah, H.Z. Idris, M.I. Lee, T.C.
author_facet	Alipal, J. Saidin, S. Kai Lo, A.Z. Koshy, P. Abdullah, H.Z. Idris, M.I. Lee, T.C.
author_sort	Alipal, J.
title	In vitro surface efficacy of CaP-based anodised titanium for bone implants
title_short	In vitro surface efficacy of CaP-based anodised titanium for bone implants
title_full	In vitro surface efficacy of CaP-based anodised titanium for bone implants
title_fullStr	In vitro surface efficacy of CaP-based anodised titanium for bone implants
title_full_unstemmed	In vitro surface efficacy of CaP-based anodised titanium for bone implants
title_sort	in vitro surface efficacy of cap-based anodised titanium for bone implants
publisher	Elsevier
publishDate	2023
url	http://eprints.uthm.edu.my/10371/1/J16043_3ebf01813a855fc8bfbea2ea2e595eb8.pdf http://eprints.uthm.edu.my/10371/ https://doi.org/10.1016/j.surfin.2023.102872
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score	13.211869

In vitro surface efficacy of CaP-based anodised titanium for bone implants

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