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Use, exposure and omics characterisation of potential hazard in nanomaterials

Nanomaterials offer the potential for positive technological impact in a variety of industries. The major breakthrough is in neurological therapeutic applications as their physical and chemical properties allow them to penetrate the blood-brain barrier (BBB). However, questions concerning its safety...

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Main Authors:	Nyuk Ling Ma, Nyuk Ling Ma, Nan Zhang, Nan Zhang, Wilson Thau Lym Yong, Wilson Thau Lym Yong, Misbah, Suzana, Hashim, Fatimah, Chin Fhong Soon, Chin Fhong Soon, Gim Pao Lim, Gim Pao Lim, Wanxi Peng, Wanxi Peng, Christian Sonne, Christian Sonne
Format:	Article
Language:	English
Published:	Elsevier 2023
Subjects:	T Technology (General)
Online Access:	http://eprints.uthm.edu.my/10268/1/J15847_33d051e5d12dd2f5ea8c23aea5b14bc3.pdf http://eprints.uthm.edu.my/10268/ https://doi.org/10.1016/j.mtadv.2023.100341
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id	my.uthm.eprints.10268
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spelling	my.uthm.eprints.102682023-10-30T07:18:09Z http://eprints.uthm.edu.my/10268/ Use, exposure and omics characterisation of potential hazard in nanomaterials Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Misbah, Suzana Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne T Technology (General) Nanomaterials offer the potential for positive technological impact in a variety of industries. The major breakthrough is in neurological therapeutic applications as their physical and chemical properties allow them to penetrate the blood-brain barrier (BBB). However, questions concerning its safety have arisen as a result of its permeability and the broad application of nanomaterials especially the engineered nanomaterial (ENMs). Due to the large spectrum of ENM properties, pinpointing individual features that caused toxicity is difficult. It is therefore urgent to capitalise on these new developments in ENM safety evaluation. Indeed, novel risk assessment and risk management techniques for humans and the environment across the whole life-cycle of nanomaterial products have emerged in recent years, including systems biology approaches and high-throughput screening platforms. Moreover, the new toxicology technology should practically reduce the number of animal samples required for testing and allow both in vitro and in vivo cell studies. Unlike traditional cytotoxicity, which limits the analysis effect to a single experiment, hazardous risk assessment by integrated omics technologies using high-throughput technologies provides robustness of systemic functional analysis towards ENM, allowing the discovery of biomarkers and functional pathways affecting ENM safety application. Elsevier 2023 Article PeerReviewed text en http://eprints.uthm.edu.my/10268/1/J15847_33d051e5d12dd2f5ea8c23aea5b14bc3.pdf Nyuk Ling Ma, Nyuk Ling Ma and Nan Zhang, Nan Zhang and Wilson Thau Lym Yong, Wilson Thau Lym Yong and Misbah, Suzana and Hashim, Fatimah and Chin Fhong Soon, Chin Fhong Soon and Gim Pao Lim, Gim Pao Lim and Wanxi Peng, Wanxi Peng and Christian Sonne, Christian Sonne (2023) Use, exposure and omics characterisation of potential hazard in nanomaterials. Materials Today Advances, 17. pp. 1-13. https://doi.org/10.1016/j.mtadv.2023.100341
institution	Universiti Tun Hussein Onn Malaysia
building	UTHM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tun Hussein Onn Malaysia
content_source	UTHM Institutional Repository
url_provider	http://eprints.uthm.edu.my/
language	English
topic	T Technology (General)
spellingShingle	T Technology (General) Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Misbah, Suzana Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne Use, exposure and omics characterisation of potential hazard in nanomaterials
description	Nanomaterials offer the potential for positive technological impact in a variety of industries. The major breakthrough is in neurological therapeutic applications as their physical and chemical properties allow them to penetrate the blood-brain barrier (BBB). However, questions concerning its safety have arisen as a result of its permeability and the broad application of nanomaterials especially the engineered nanomaterial (ENMs). Due to the large spectrum of ENM properties, pinpointing individual features that caused toxicity is difficult. It is therefore urgent to capitalise on these new developments in ENM safety evaluation. Indeed, novel risk assessment and risk management techniques for humans and the environment across the whole life-cycle of nanomaterial products have emerged in recent years, including systems biology approaches and high-throughput screening platforms. Moreover, the new toxicology technology should practically reduce the number of animal samples required for testing and allow both in vitro and in vivo cell studies. Unlike traditional cytotoxicity, which limits the analysis effect to a single experiment, hazardous risk assessment by integrated omics technologies using high-throughput technologies provides robustness of systemic functional analysis towards ENM, allowing the discovery of biomarkers and functional pathways affecting ENM safety application.
format	Article
author	Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Misbah, Suzana Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne
author_facet	Nyuk Ling Ma, Nyuk Ling Ma Nan Zhang, Nan Zhang Wilson Thau Lym Yong, Wilson Thau Lym Yong Misbah, Suzana Hashim, Fatimah Chin Fhong Soon, Chin Fhong Soon Gim Pao Lim, Gim Pao Lim Wanxi Peng, Wanxi Peng Christian Sonne, Christian Sonne
author_sort	Nyuk Ling Ma, Nyuk Ling Ma
title	Use, exposure and omics characterisation of potential hazard in nanomaterials
title_short	Use, exposure and omics characterisation of potential hazard in nanomaterials
title_full	Use, exposure and omics characterisation of potential hazard in nanomaterials
title_fullStr	Use, exposure and omics characterisation of potential hazard in nanomaterials
title_full_unstemmed	Use, exposure and omics characterisation of potential hazard in nanomaterials
title_sort	use, exposure and omics characterisation of potential hazard in nanomaterials
publisher	Elsevier
publishDate	2023
url	http://eprints.uthm.edu.my/10268/1/J15847_33d051e5d12dd2f5ea8c23aea5b14bc3.pdf http://eprints.uthm.edu.my/10268/ https://doi.org/10.1016/j.mtadv.2023.100341
_version_	1781707457784971264
score	13.211869

Use, exposure and omics characterisation of potential hazard in nanomaterials

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