Cover Image

Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity

The application of porous bioactive ceramics as bone substitutes requires their effective osseointegration, which relies on specific physical and biological properties. In this study, we developed porous magnesium-doped hydroxyapatite (MgHA) ceramics with four different magnesium concentrations (0....

Full description

Saved in:
Bibliographic Details
Main Authors: Iis, Sopyan, Abd Rahim, Toibah, Singh, Ramesh, Maizirwan, Mel, Alqap, Asep Sofwan Faturahman
Format: Article
Language:English
Published: Elsevier Ltd 2024
Online Access:http://eprints.utem.edu.my/id/eprint/27727/2/017362901202413528695.pdf
http://eprints.utem.edu.my/id/eprint/27727/
https://www.sciencedirect.com/science/article/pii/S0272884223043493
https://doi.org/10.1016/j.ceramint.2023.12.413
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.utem.eprints.27727
record_format eprints
spelling my.utem.eprints.277272024-10-07T12:26:22Z http://eprints.utem.edu.my/id/eprint/27727/ Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity Iis, Sopyan Abd Rahim, Toibah Singh, Ramesh Maizirwan, Mel Alqap, Asep Sofwan Faturahman The application of porous bioactive ceramics as bone substitutes requires their effective osseointegration, which relies on specific physical and biological properties. In this study, we developed porous magnesium-doped hydroxyapatite (MgHA) ceramics with four different magnesium concentrations (0.25, 2, 5 and 10 mol%). The ceramics were prepared through the polymeric replication sponge method and subjected to physical and biological characterizations. Upon sintering, the porous 10 mol% MgHA ceramics exhibited increased densification, which resulted in the highest compressive strength of 2.17 MPa at the lowest porosity of 31 %. The porous samples were analysed via microcomputed tomography. The scaffolds with 0.25 and 10 mol% Mg doping concentrations were selected to elucidate the influence of Mg on morphometric parameters and biological properties at two distinct levels. The high level of Mg doping led to considerable improvements in relative bone volume, connectivity density, trabecular number and trabecular thickness. Cell attachment and proliferation tests using Vero cell lines were conducted on both samples to investigate the correlations between their morphometric parameters and bioactivities. Substantially more cells attached to and proliferated on the surface of the 10 mol% MgHA ceramics compared with those on the ceramics containing 0.25 mol% MgHA. In summary, our study underscores the effectiveness of Mg incorporation in improving the physical and biological properties of porous HA ceramics, which makes them promising candidates for bone substitute applications. Elsevier Ltd 2024-01 Article PeerReviewed text en http://eprints.utem.edu.my/id/eprint/27727/2/017362901202413528695.pdf Iis, Sopyan and Abd Rahim, Toibah and Singh, Ramesh and Maizirwan, Mel and Alqap, Asep Sofwan Faturahman (2024) Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity. Ceramics International, 50 (7). pp. 10967-10973. ISSN 0272-8842 https://www.sciencedirect.com/science/article/pii/S0272884223043493 https://doi.org/10.1016/j.ceramint.2023.12.413
institution Universiti Teknikal Malaysia Melaka
building UTEM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknikal Malaysia Melaka
content_source UTEM Institutional Repository
url_provider http://eprints.utem.edu.my/
language English
description The application of porous bioactive ceramics as bone substitutes requires their effective osseointegration, which relies on specific physical and biological properties. In this study, we developed porous magnesium-doped hydroxyapatite (MgHA) ceramics with four different magnesium concentrations (0.25, 2, 5 and 10 mol%). The ceramics were prepared through the polymeric replication sponge method and subjected to physical and biological characterizations. Upon sintering, the porous 10 mol% MgHA ceramics exhibited increased densification, which resulted in the highest compressive strength of 2.17 MPa at the lowest porosity of 31 %. The porous samples were analysed via microcomputed tomography. The scaffolds with 0.25 and 10 mol% Mg doping concentrations were selected to elucidate the influence of Mg on morphometric parameters and biological properties at two distinct levels. The high level of Mg doping led to considerable improvements in relative bone volume, connectivity density, trabecular number and trabecular thickness. Cell attachment and proliferation tests using Vero cell lines were conducted on both samples to investigate the correlations between their morphometric parameters and bioactivities. Substantially more cells attached to and proliferated on the surface of the 10 mol% MgHA ceramics compared with those on the ceramics containing 0.25 mol% MgHA. In summary, our study underscores the effectiveness of Mg incorporation in improving the physical and biological properties of porous HA ceramics, which makes them promising candidates for bone substitute applications.
format Article
author Iis, Sopyan
Abd Rahim, Toibah
Singh, Ramesh
Maizirwan, Mel
Alqap, Asep Sofwan Faturahman
spellingShingle Iis, Sopyan
Abd Rahim, Toibah
Singh, Ramesh
Maizirwan, Mel
Alqap, Asep Sofwan Faturahman
Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
author_facet Iis, Sopyan
Abd Rahim, Toibah
Singh, Ramesh
Maizirwan, Mel
Alqap, Asep Sofwan Faturahman
author_sort Iis, Sopyan
title Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_short Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_full Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_fullStr Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_full_unstemmed Magnesium-enhanced porous hydroxyapatite ceramics: Morphometric parameters, physical properties and bioactivity
title_sort magnesium-enhanced porous hydroxyapatite ceramics: morphometric parameters, physical properties and bioactivity
publisher Elsevier Ltd
publishDate 2024
url http://eprints.utem.edu.my/id/eprint/27727/2/017362901202413528695.pdf
http://eprints.utem.edu.my/id/eprint/27727/
https://www.sciencedirect.com/science/article/pii/S0272884223043493
https://doi.org/10.1016/j.ceramint.2023.12.413
_version_ 1814061420809027584
score 13.211869

Similar Items