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Aptamer‑based rapid diagnosis for point‑of‑care application

Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades,...

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Main Authors: Narayanamurthy, Vigneswaran, Futane, Abhishek Shankar, Jadhav, Pramod, Srinivasan, Arthi
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2023
Online Access:http://eprints.utem.edu.my/id/eprint/27565/2/0263119062023230.PDF
http://eprints.utem.edu.my/id/eprint/27565/
https://www.scopus.com/record/display.uri?eid=2-s2.0-85146605827&origin=resultslist&sort=plf-f&src=s&sid=66ca623ba91ef0861f2e0b22fd8fdc34&sot=b&sdt=b&s=TITLE-ABS-KEY%28APTAMER-BASED+RAPID+DIAGNOSIS+FOR+POINT-OF-CARE+APPLICATION%29&sl=74&sessionSearchId=66ca623ba91ef0861f2e0b22fd8fdc34&relpos=4
https://doi.org/10.1007/s10404-022-02622-3
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spelling my.utem.eprints.275652024-07-04T11:46:11Z http://eprints.utem.edu.my/id/eprint/27565/ Aptamer‑based rapid diagnosis for point‑of‑care application Narayanamurthy, Vigneswaran Futane, Abhishek Shankar Jadhav, Pramod Srinivasan, Arthi Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades, biosensors have been introduced that ofer more reliable, cost-efective, and accurate detection methods. Aptamer-based biosensors have unprecedented advantages over biosensors that use natural receptors such as antibodies and enzymes. In the current epidemic, point-of-care testing (POCT) is advantageous because it is easy to use, more accessible, faster to detect, and has high accuracy and sensitivity, reducing the burden of testing on healthcare systems. POCT is benefcial for daily epidemic control as well as early detection and treatment. This review provides detailed information on the various design strategies and virus detection methods using aptamer-based sensors. In addition, we discussed the importance of diferent aptamers and their detection principles. Aptasensors with higher sensitivity, specifcity, and fexibility are critically discussed to establish simple, cost-efective, and rapid detection methods. POC-based aptasensors’ diagnostic applications are classifed and summarised based on infectious and infectious diseases. Finally, the design factors to be considered are outlined to meet the future of rapid POC-based sensors. Springer Science and Business Media Deutschland GmbH 2023-02 Article PeerReviewed text en http://eprints.utem.edu.my/id/eprint/27565/2/0263119062023230.PDF Narayanamurthy, Vigneswaran and Futane, Abhishek Shankar and Jadhav, Pramod and Srinivasan, Arthi (2023) Aptamer‑based rapid diagnosis for point‑of‑care application. Microfluidics and Nanofluidics, 27 (2). pp. 1-33. ISSN 1613-4982 https://www.scopus.com/record/display.uri?eid=2-s2.0-85146605827&origin=resultslist&sort=plf-f&src=s&sid=66ca623ba91ef0861f2e0b22fd8fdc34&sot=b&sdt=b&s=TITLE-ABS-KEY%28APTAMER-BASED+RAPID+DIAGNOSIS+FOR+POINT-OF-CARE+APPLICATION%29&sl=74&sessionSearchId=66ca623ba91ef0861f2e0b22fd8fdc34&relpos=4 https://doi.org/10.1007/s10404-022-02622-3
institution Universiti Teknikal Malaysia Melaka
building UTEM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknikal Malaysia Melaka
content_source UTEM Institutional Repository
url_provider http://eprints.utem.edu.my/
language English
description Aptasensors have attracted considerable interest and widespread application in point-of-care testing worldwide. One of the biggest challenges of a point-of-care (POC) is the reduction of treatment time compared to central facilities that diagnose and monitor the applications. Over the past decades, biosensors have been introduced that ofer more reliable, cost-efective, and accurate detection methods. Aptamer-based biosensors have unprecedented advantages over biosensors that use natural receptors such as antibodies and enzymes. In the current epidemic, point-of-care testing (POCT) is advantageous because it is easy to use, more accessible, faster to detect, and has high accuracy and sensitivity, reducing the burden of testing on healthcare systems. POCT is benefcial for daily epidemic control as well as early detection and treatment. This review provides detailed information on the various design strategies and virus detection methods using aptamer-based sensors. In addition, we discussed the importance of diferent aptamers and their detection principles. Aptasensors with higher sensitivity, specifcity, and fexibility are critically discussed to establish simple, cost-efective, and rapid detection methods. POC-based aptasensors’ diagnostic applications are classifed and summarised based on infectious and infectious diseases. Finally, the design factors to be considered are outlined to meet the future of rapid POC-based sensors.
format Article
author Narayanamurthy, Vigneswaran
Futane, Abhishek Shankar
Jadhav, Pramod
Srinivasan, Arthi
spellingShingle Narayanamurthy, Vigneswaran
Futane, Abhishek Shankar
Jadhav, Pramod
Srinivasan, Arthi
Aptamer‑based rapid diagnosis for point‑of‑care application
author_facet Narayanamurthy, Vigneswaran
Futane, Abhishek Shankar
Jadhav, Pramod
Srinivasan, Arthi
author_sort Narayanamurthy, Vigneswaran
title Aptamer‑based rapid diagnosis for point‑of‑care application
title_short Aptamer‑based rapid diagnosis for point‑of‑care application
title_full Aptamer‑based rapid diagnosis for point‑of‑care application
title_fullStr Aptamer‑based rapid diagnosis for point‑of‑care application
title_full_unstemmed Aptamer‑based rapid diagnosis for point‑of‑care application
title_sort aptamer‑based rapid diagnosis for point‑of‑care application
publisher Springer Science and Business Media Deutschland GmbH
publishDate 2023
url http://eprints.utem.edu.my/id/eprint/27565/2/0263119062023230.PDF
http://eprints.utem.edu.my/id/eprint/27565/
https://www.scopus.com/record/display.uri?eid=2-s2.0-85146605827&origin=resultslist&sort=plf-f&src=s&sid=66ca623ba91ef0861f2e0b22fd8fdc34&sot=b&sdt=b&s=TITLE-ABS-KEY%28APTAMER-BASED+RAPID+DIAGNOSIS+FOR+POINT-OF-CARE+APPLICATION%29&sl=74&sessionSearchId=66ca623ba91ef0861f2e0b22fd8fdc34&relpos=4
https://doi.org/10.1007/s10404-022-02622-3
_version_ 1804070320298000384
score 13.211869

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