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Extraction of natural hydroxyapatite for biomedical applications—a review

Hydroxyapatite has recently played a crucial role in the sustainable development of biomedical applications. Publications related to hydroxyapatite as filler for biopolymers have exhibited an increasing trend due to the expanding research output. Based on the latest publications, the authors reviewe...

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Main Authors: Abdulah, Hasan Zuhudi, Hussin, Mohamed Saiful Firdaus, Idris, Maizlinda Izwana, Abdul Wahap, Mohd Arizam
Format: Article
Language:English
Published: Elsevier Ltd 2022
Online Access:http://eprints.utem.edu.my/id/eprint/26389/2/HELIYON-D-22-10905%20%281%29.PDF
http://eprints.utem.edu.my/id/eprint/26389/
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institution Universiti Teknikal Malaysia Melaka
building UTEM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknikal Malaysia Melaka
content_source UTEM Institutional Repository
url_provider http://eprints.utem.edu.my/
language English
description Hydroxyapatite has recently played a crucial role in the sustainable development of biomedical applications. Publications related to hydroxyapatite as filler for biopolymers have exhibited an increasing trend due to the expanding research output. Based on the latest publications, the authors reviewed the research trends regarding hydroxyapatite use in biomedical applications. Analysis of the Scopus database using the keywords ‘hydroxyapatite” and “biomedical applications” determined that 1,714 papers were produced between 2012 and 2021. The number of publications related to these keywords more than doubled between 2012 (99) and 2021 (247). The hydrothermal method, solid-state reactions, the sol-gel process, emulsion, micro-emulsion, and mostly chemical precipitation were used to produce synthetic hydroxyapatite. Meanwhile, calcination, alkaline hydrolysis, precipitation, hydrothermal, and a combination of these techniques were used in producing natural hydroxyapatite. Studies in the current literature reveal that shell-based animal sources have been frequently used as hydroxyapatite resources during investigations concerning biomedical applications, while calcination was the extraction method most often applied. Essential trace elements of fish bone, oyster shell, and eggshell were also found in hydroxyapatite powder. Abalone mussel shell and eggshell showed Ca/P ratios closer to the stoichiometric ratio due to the use of effective extraction methods such as manipulating aging time or stirring process parameters. This review should greatly assist by offering scientific insights to support all the recommended future research works, not only that associated with biomedical applications.
format Article
author Abdulah, Hasan Zuhudi
Hussin, Mohamed Saiful Firdaus
Idris, Maizlinda Izwana
Abdul Wahap, Mohd Arizam
spellingShingle Abdulah, Hasan Zuhudi
Hussin, Mohamed Saiful Firdaus
Idris, Maizlinda Izwana
Abdul Wahap, Mohd Arizam
Extraction of natural hydroxyapatite for biomedical applications—a review
author_facet Abdulah, Hasan Zuhudi
Hussin, Mohamed Saiful Firdaus
Idris, Maizlinda Izwana
Abdul Wahap, Mohd Arizam
author_sort Abdulah, Hasan Zuhudi
title Extraction of natural hydroxyapatite for biomedical applications—a review
title_short Extraction of natural hydroxyapatite for biomedical applications—a review
title_full Extraction of natural hydroxyapatite for biomedical applications—a review
title_fullStr Extraction of natural hydroxyapatite for biomedical applications—a review
title_full_unstemmed Extraction of natural hydroxyapatite for biomedical applications—a review
title_sort extraction of natural hydroxyapatite for biomedical applications—a review
publisher Elsevier Ltd
publishDate 2022
url http://eprints.utem.edu.my/id/eprint/26389/2/HELIYON-D-22-10905%20%281%29.PDF
http://eprints.utem.edu.my/id/eprint/26389/
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spelling my.utem.eprints.263892023-02-23T11:15:00Z http://eprints.utem.edu.my/id/eprint/26389/ Extraction of natural hydroxyapatite for biomedical applications—a review Abdulah, Hasan Zuhudi Hussin, Mohamed Saiful Firdaus Idris, Maizlinda Izwana Abdul Wahap, Mohd Arizam Hydroxyapatite has recently played a crucial role in the sustainable development of biomedical applications. Publications related to hydroxyapatite as filler for biopolymers have exhibited an increasing trend due to the expanding research output. Based on the latest publications, the authors reviewed the research trends regarding hydroxyapatite use in biomedical applications. Analysis of the Scopus database using the keywords ‘hydroxyapatite” and “biomedical applications” determined that 1,714 papers were produced between 2012 and 2021. The number of publications related to these keywords more than doubled between 2012 (99) and 2021 (247). The hydrothermal method, solid-state reactions, the sol-gel process, emulsion, micro-emulsion, and mostly chemical precipitation were used to produce synthetic hydroxyapatite. Meanwhile, calcination, alkaline hydrolysis, precipitation, hydrothermal, and a combination of these techniques were used in producing natural hydroxyapatite. Studies in the current literature reveal that shell-based animal sources have been frequently used as hydroxyapatite resources during investigations concerning biomedical applications, while calcination was the extraction method most often applied. Essential trace elements of fish bone, oyster shell, and eggshell were also found in hydroxyapatite powder. Abalone mussel shell and eggshell showed Ca/P ratios closer to the stoichiometric ratio due to the use of effective extraction methods such as manipulating aging time or stirring process parameters. This review should greatly assist by offering scientific insights to support all the recommended future research works, not only that associated with biomedical applications. Elsevier Ltd 2022-08-15 Article PeerReviewed text en http://eprints.utem.edu.my/id/eprint/26389/2/HELIYON-D-22-10905%20%281%29.PDF Abdulah, Hasan Zuhudi and Hussin, Mohamed Saiful Firdaus and Idris, Maizlinda Izwana and Abdul Wahap, Mohd Arizam (2022) Extraction of natural hydroxyapatite for biomedical applications—a review. Heliyon, 8 (8). 01-36. ISSN 2405-8440 https://pdf.sciencedirectassets.com/313379/1-s2.0-S2405844021X00096/1-s2.0-S2405844022016449/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEKT%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIBEHGy38q7%2FKdFy9cpIV5hZ%2BCus2FD2U2RfzVJZse7WgAiEAxuAFoCTLtwHt0dGMH%2FhaEMW4CWCA7X%2BlksW%2BjHgIoTgqzAQIPRAFGgwwNTkwMDM1NDY4NjUiDE73yymq2K%2Byx4clOyqpBMilwUUoOj2wn8%2FKs%2BqboLymGVss0NrgGWnRnzWRAgFsGabQ40ltgtY7GpYQII1hKG%2BmkksefRQwpQj3PxVu07gZZsNYOVswlrF47jMiflq9phVlZnC04XjAjfjkkS%2BqmLUq%2BslVaOWbSUbw67wwqXe1q9wbtxwfpw28w1lbq0wcRsDhugex2LQ3oQQ7hfjBVAR5WL1SYXBHJerthcRB23EwNeabzpgH6LJw0jW8bbxzSljrmQz1B5GVX2C%2FuPdpSqwPPl0U5aZhej9NwUzd07ZRRJ5DEY60sL2N31I3oXljd%2BQ5MoCCdNh0ZtBfhFWPhEUUlVknAlOwZ02yu9knVpRITud45UddsfHwqEiFMt%2Fu%2BzOPuE3cBGCGTZ4vXXtm1OcMyZ4%2Fut%2B2KdxOAEzaTjVrz8EMyBLSI81WU6XfYUmosx%2FYsuXPOjN6N%2BjLGqyu4ykCmLrP9viC6oKEMLfu8hb6Ms4l2yTqCPPztCZr8xynhR20LZel0Qk%2FkzNulqbdOK2NwhB%2FvTOS3MTR9V9PJBcvdxY%2BHW%2FaxOOlXjK10rINpDirAgD%2FuVWerM8rRRUhWd6NyLQcQw2ZDB3oyfLvwZby9GF2wz1ghg6VHdzEA6ggq37ytkl8ZN11y9xpi49iSK5JGlbPSY%2B8iZ9FZnYytADqxVxufButhiq7oK5EORIIWqBSjZTN18IMPIpe7xwMpyhQXF8nY8Hkg39dnjXjvHpjsfFPX91bL2Awtc62nwY6qQFeRcYfczpkUGcasqArl8Rl2lXno5SVL9vX5apuMdRrRc4Iqo436xVzhhmy9XYtM6KnCo%2FmnY1SMe72vIhdjxhKSiO06B1rLfHgoNZzWP05APAe%2BwFB%2Fh5JRYgc0KwPILJSn6VHWitOlb61XX6fzajb%2FccKY287ZhWchYBusN646qO05gWkhhPxqcOQdlzIQhJjAHzhqnf1tGR%2FsTqHTZD8vpUk083DlB9e&X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Date=20230216T050036Z&X-Amz-SignedHeaders=host&X-Amz-Expires=300&X-Amz-Credential=ASIAQ3PHCVTY2P2S4MGQ%2F20230216%2Fus-east-1%2Fs3%2Faws4_request&X-Amz-Signature=ec26c5aee7a2d49ec9062a1ef63bb798835bf38ff59921cec5eee06c22be4f57&hash=8e683496feb62532259afad1aca605674f8c1c7f95b04ddd80bdbe40cffa3d71&host=68042c943591013ac2b2430a89b270f6af2c76d8dfd086a07176afe7c76c2c61&pii=S2405844022016449&tid=spdf-bdffb2e9-a643-4292-9949-d2d32d489246&sid=a4a52c0b70da984d7c295a393cbf58277a0dgxrqb&type=client&tsoh=d3d3LnNjaWVuY2VkaXJlY3QuY29t&ua=031c585f0f5d0d5d53&rr=79a3b8799f2b0cf8&cc=my 10.1016/j.heliyon.2022.e10356
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