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Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom

Background: Intracavitary brachytherapy has become one of the most important treatments for cervical cancer, along with the use of the applicator during its treatment delivery. The most common applicator used is Fletcher’s applicator. To ensure the accurate treatment of brachytherapy, the dose verif...

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Main Author: Sallehudin,, Muhammad Nursyabil
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2024
Subjects:
R Medicine
RC254-282 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:http://eprints.usm.my/61359/1/MUHAMMAD%20NURSYABIL%20BIN%20SALLEHUDIN-E.pdf
http://eprints.usm.my/61359/
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spelling my.usm.eprints.61359 http://eprints.usm.my/61359/ Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom Sallehudin,, Muhammad Nursyabil R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Background: Intracavitary brachytherapy has become one of the most important treatments for cervical cancer, along with the use of the applicator during its treatment delivery. The most common applicator used is Fletcher’s applicator. To ensure the accurate treatment of brachytherapy, the dose verification of the treatment must be done before the treatment delivery. However, there is a lack of studies on dose verification in cervical cancer brachytherapy that address the discrepancies between the planned dose and the delivered dose using heterogeneous phantoms, especially the one using the Fletcher applicator. Purpose: This study aims to assess the dose distribution and dosimetry performance achieved by the Fletcher’s applicator and perform dose verification in HDR brachytherapy. Materials and Method: The eight sets of thermoluminescence dosimeters (TLD), calibrated using an Iridium-192 source, were placed across the bladder and rectum organ at risk (OAR) inside the heterogenous pelvic water phantom and computed tomography (CT) scanned for image acquisition. The planning of the cervical brachytherapy is done to obtain the calculated TPS dose using the CT image with an 8Gy dose prescription. The phantom is then irradiated along with the TLD to obtain the irradiated TLD-measured dose. The comparison between the TPS calculated dose and the TLD measured dose was done. Results: Two of the eight TLD, G2 (5.883%) and G4 (-17.526%), show a dose deviation less than 20% from the TPS calculated dose, while the other six TLD exceed the 20% dose limit, with G9 showing the highest deviation, -278.726% between the calculated and measured dose. Conclusion: the result of the study shows significant deviation between TPS calculated dose and the TLD measured dose in HDR brachytherapy using Fletcher’s applicator inside heterogenous phantom, with most percentage different exceeding the acceptable tolerance due to several factor mainly the applicator being mispositioned. Universiti Sains Malaysia 2024 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/61359/1/MUHAMMAD%20NURSYABIL%20BIN%20SALLEHUDIN-E.pdf Sallehudin,, Muhammad Nursyabil (2024) Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom. Project Report. Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
RC254-282 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle R Medicine
RC254-282 Neoplasms. Tumors. Oncology (including Cancer)
Sallehudin,, Muhammad Nursyabil
Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom
description Background: Intracavitary brachytherapy has become one of the most important treatments for cervical cancer, along with the use of the applicator during its treatment delivery. The most common applicator used is Fletcher’s applicator. To ensure the accurate treatment of brachytherapy, the dose verification of the treatment must be done before the treatment delivery. However, there is a lack of studies on dose verification in cervical cancer brachytherapy that address the discrepancies between the planned dose and the delivered dose using heterogeneous phantoms, especially the one using the Fletcher applicator. Purpose: This study aims to assess the dose distribution and dosimetry performance achieved by the Fletcher’s applicator and perform dose verification in HDR brachytherapy. Materials and Method: The eight sets of thermoluminescence dosimeters (TLD), calibrated using an Iridium-192 source, were placed across the bladder and rectum organ at risk (OAR) inside the heterogenous pelvic water phantom and computed tomography (CT) scanned for image acquisition. The planning of the cervical brachytherapy is done to obtain the calculated TPS dose using the CT image with an 8Gy dose prescription. The phantom is then irradiated along with the TLD to obtain the irradiated TLD-measured dose. The comparison between the TPS calculated dose and the TLD measured dose was done. Results: Two of the eight TLD, G2 (5.883%) and G4 (-17.526%), show a dose deviation less than 20% from the TPS calculated dose, while the other six TLD exceed the 20% dose limit, with G9 showing the highest deviation, -278.726% between the calculated and measured dose. Conclusion: the result of the study shows significant deviation between TPS calculated dose and the TLD measured dose in HDR brachytherapy using Fletcher’s applicator inside heterogenous phantom, with most percentage different exceeding the acceptable tolerance due to several factor mainly the applicator being mispositioned.
format Monograph
author Sallehudin,, Muhammad Nursyabil
author_facet Sallehudin,, Muhammad Nursyabil
author_sort Sallehudin,, Muhammad Nursyabil
title Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom
title_short Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom
title_full Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom
title_fullStr Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom
title_full_unstemmed Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom
title_sort dosimetric study of fletcher’s applicator in high-dose-rate (hdr) brachytherapy for cervical cancer: tld measurements in pelvic water phantom
publisher Universiti Sains Malaysia
publishDate 2024
url http://eprints.usm.my/61359/1/MUHAMMAD%20NURSYABIL%20BIN%20SALLEHUDIN-E.pdf
http://eprints.usm.my/61359/
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score 13.23648

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