The effects of iridium nanoparticles in radiation dose enhancement in external beam radiation therapy
Metal based nanoparticles such as gold nanoparticles, silver nanoparticles, iron oxide nanoparticles and gadolinium nanoparticles have been investigated for their potential to increase the therapeutic effects of radiotherapy. However, Iridium nanoparticles have never been tested so far and the pur...
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| Main Author: | |
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| Format: | Monograph |
| Language: | English |
| Published: |
Universiti Sains Malaysia
2016
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| Subjects: | |
| Online Access: | http://eprints.usm.my/61243/1/NUR%20AMANINA%20BINTI%20MD%20ISA%20-%20e.pdf http://eprints.usm.my/61243/ |
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| Summary: | Metal based nanoparticles such as gold nanoparticles, silver nanoparticles, iron
oxide nanoparticles and gadolinium nanoparticles have been investigated for their
potential to increase the therapeutic effects of radiotherapy. However, Iridium nanoparticles have never been tested so far and the purpose of this study is to investigate the effects of Iridium nanoparticles on radiation dose enhancement in
External Beam Radiation Therapy (EBRT). The HeLa cells were incubated with two different concentrations of Iridium
NPs at 0.1 mM/L and 0.5 mM/L. The samples of HeLa cells were then irradiated with
photon beam of 6 MV energy and electron beam of 6 MeV energy. Cumulative dose ranges from 0.5 to 10 Gy were applied during irradiation process. The cells’
proliferation after irradiation were observed by mean of clonogenic assay. The evaluation of the radiosensitivity of HeLa cells with and without the inclusion of
Iridium nanoparticles towards both type of radiation beams were done by plotting
survival curves and was fitted to linear quadratic formalism. The results shows that DEF obtained for photon beam at 0.1 mM/L and 0.5
mM/L are 1.08 and 2.10 respectively while for electron beam the values generated at
0.1 mM/L is 1.17 and for 0.5mM/L is 1.13. The cell survival curves of HeLa cells with
inclusion of Iridium nanoparticles was steeper compared to the control cells. This
indicated that Iridium nanoparticles shows dose enhancement effect on HeLa cells. It is
also established that the shape of the cell survival curve is affected by different radiation
beams and Iridium NPs concentration. This study concluded that the Iridium nanoparticles are proven to be one
of the potential radiosensitizers in radiotherapy. Dose enhancement effects is observed
to be dependent on radiation beam types and nanoparticles |
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