Cover Image

Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam

Gold nanoparticles (AuNPs) have been widely investigated as radiation dose enhancer for radiotherapy due to its intriguing potential in increasing radiotherapy therapeutic efficiency. The applicability of AuNPs depends on many factors including nanoparticles size. In this study, the effects of na...

Full description

Saved in:
Bibliographic Details
Main Author: Muhammad, Mahfuzah
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2016
Subjects:
R735-854 Medical education. Medical schools. Research
RC71-78.7 Examination. Diagnosis Including raiography
Online Access:http://eprints.usm.my/61238/1/MAHFUZAH%20BINTI%20MUHAMMAD%20-%20e.pdf
http://eprints.usm.my/61238/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usm.eprints.61238
record_format eprints
spelling my.usm.eprints.61238 http://eprints.usm.my/61238/ Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam Muhammad, Mahfuzah R735-854 Medical education. Medical schools. Research RC71-78.7 Examination. Diagnosis Including raiography Gold nanoparticles (AuNPs) have been widely investigated as radiation dose enhancer for radiotherapy due to its intriguing potential in increasing radiotherapy therapeutic efficiency. The applicability of AuNPs depends on many factors including nanoparticles size. In this study, the effects of nanoparticle size on the AuNPs dose enhancement effects were investigated. AuNPs of 5nm and 15 nm were used in this study. The efficacy of both sizes of AuNPs was tested in-vitro using HeLa cell lines. The cells were incubated with the AuNPs and irradiated at different doses with 6 MV photon beam at 100 cm SSD and 10 cm x 10 cm field size. Cell survival curves were obtained from standard clonogenic assay and fitted to the Linear Quadratic (LQ) model using OriginPro 9.2 software. Dose enhancement factor (DEF) and radioparameters were extrapolated and evaluated from the cell survival curve. The results show that 15 nm AuNPs produce better dose enhancement compare to 5 nm of AuNPs. DEF for 15 nm are found to be around 2.2 meanwhile for 5nm is 1.75. The curves also demonstrate steepest slope and small shoulder for larger size AuNPs which indicate increase in biological effects. The LQ parameters such as alpha, beta and alpha/beta ratio are in agreement with the DEF results. Larger size AuNPs produce higher dose enhancement compare to small size of AuNPs which conclude that nanoparticles size is important factor that need to be taken into account for AuNPs to be applied in radiotherapy. Universiti Sains Malaysia 2016 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/61238/1/MAHFUZAH%20BINTI%20MUHAMMAD%20-%20e.pdf Muhammad, Mahfuzah (2016) Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam. Project Report. Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R735-854 Medical education. Medical schools. Research
RC71-78.7 Examination. Diagnosis Including raiography
spellingShingle R735-854 Medical education. Medical schools. Research
RC71-78.7 Examination. Diagnosis Including raiography
Muhammad, Mahfuzah
Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam
description Gold nanoparticles (AuNPs) have been widely investigated as radiation dose enhancer for radiotherapy due to its intriguing potential in increasing radiotherapy therapeutic efficiency. The applicability of AuNPs depends on many factors including nanoparticles size. In this study, the effects of nanoparticle size on the AuNPs dose enhancement effects were investigated. AuNPs of 5nm and 15 nm were used in this study. The efficacy of both sizes of AuNPs was tested in-vitro using HeLa cell lines. The cells were incubated with the AuNPs and irradiated at different doses with 6 MV photon beam at 100 cm SSD and 10 cm x 10 cm field size. Cell survival curves were obtained from standard clonogenic assay and fitted to the Linear Quadratic (LQ) model using OriginPro 9.2 software. Dose enhancement factor (DEF) and radioparameters were extrapolated and evaluated from the cell survival curve. The results show that 15 nm AuNPs produce better dose enhancement compare to 5 nm of AuNPs. DEF for 15 nm are found to be around 2.2 meanwhile for 5nm is 1.75. The curves also demonstrate steepest slope and small shoulder for larger size AuNPs which indicate increase in biological effects. The LQ parameters such as alpha, beta and alpha/beta ratio are in agreement with the DEF results. Larger size AuNPs produce higher dose enhancement compare to small size of AuNPs which conclude that nanoparticles size is important factor that need to be taken into account for AuNPs to be applied in radiotherapy.
format Monograph
author Muhammad, Mahfuzah
author_facet Muhammad, Mahfuzah
author_sort Muhammad, Mahfuzah
title Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam
title_short Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam
title_full Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam
title_fullStr Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam
title_full_unstemmed Dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam
title_sort dose enhancement effects with different size of gold nanoparticles for 6 mv photon beam
publisher Universiti Sains Malaysia
publishDate 2016
url http://eprints.usm.my/61238/1/MAHFUZAH%20BINTI%20MUHAMMAD%20-%20e.pdf
http://eprints.usm.my/61238/
_version_ 1817842961599168512
score 13.223943

Similar Items