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Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac

The Monaco TPS, employing the Monte Carlo dose calculation algorithm, offers high precision in radiotherapy planning. Accurate dose calculation in heterogeneous tissues necessitates comprehensive commissioning and verification due to its impact on patient outcomes. This study evaluates the dose calc...

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Main Author: Azlan, Adriana Batrisyia Noor Mohd
Format: Thesis
Language:English
Published: 2024
Subjects:
R Medicine
RA440-440.87 Study and teaching. Research
Online Access:http://eprints.usm.my/61084/1/Adriana%20Batrisyia%20Noor%20Mohd%20Azlan-E.pdf
http://eprints.usm.my/61084/
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spelling my.usm.eprints.61084 http://eprints.usm.my/61084/ Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac Azlan, Adriana Batrisyia Noor Mohd R Medicine RA440-440.87 Study and teaching. Research The Monaco TPS, employing the Monte Carlo dose calculation algorithm, offers high precision in radiotherapy planning. Accurate dose calculation in heterogeneous tissues necessitates comprehensive commissioning and verification due to its impact on patient outcomes. This study evaluates the dose calculation accuracy of Monaco TPS using Rando phantoms, thermoluminescence dosimeters (TLD-100) dosimeters, EBT3 Gafchromic films, and clinical patient data through patient-specific quality assurance (PSQA). Methods : Dosimetric verification of Monaco TPS was conducted on a head and neck Rando phantom for 3D conformal radiotherapy (3DCRT) whole brain radiotherapy (WBRT) and volumetric modulated arc therapy (VMAT) meningioma planning in heterogeneous environments, using 12 TLD-100s and EBT3 Gafchromic films. Additionally, six Eclipse TPS patient plans were replicated on Monaco TPS, and PSQA was performed using gamma criteria of 3% dose difference (DD) and 3 mm distance-to-agreement (DTA). Results :Monaco TPS demonstrated consistent percentage deviations within ±10% (ranging from 1.8% to 9.1%) between TPS calculated and TLD-measured doses for 3DCRT, with no significant difference (p > 0.05). EBT3 Gafchromic film dosimetry showed good agreement with TPS dose distributions, achieving a 97.3% gamma passing rate. However, VMAT planning revealed significant deviations (3.06% to 67.88%) between calculated and measured doses, with a significant difference (p < 0.01) and a 52.5% gamma passing rate for film dosimetry. PSQA for six patient plans yielded high gamma passing rates (97.5% to 100%) and absolute dose deviations ranging from 0.29% to 3.48%.Conclusion : Monaco TPS is reliable and accurately commissioned for 3DCRT planning but shows significant deviations in VMAT planning. Future efforts should aim to improve verification methods, address challenges in gamma index analysis, and enhance VMAT dose calculation accuracy for consistent treatment planning. 2024-07 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/61084/1/Adriana%20Batrisyia%20Noor%20Mohd%20Azlan-E.pdf Azlan, Adriana Batrisyia Noor Mohd (2024) Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac. Other thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
RA440-440.87 Study and teaching. Research
spellingShingle R Medicine
RA440-440.87 Study and teaching. Research
Azlan, Adriana Batrisyia Noor Mohd
Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
description The Monaco TPS, employing the Monte Carlo dose calculation algorithm, offers high precision in radiotherapy planning. Accurate dose calculation in heterogeneous tissues necessitates comprehensive commissioning and verification due to its impact on patient outcomes. This study evaluates the dose calculation accuracy of Monaco TPS using Rando phantoms, thermoluminescence dosimeters (TLD-100) dosimeters, EBT3 Gafchromic films, and clinical patient data through patient-specific quality assurance (PSQA). Methods : Dosimetric verification of Monaco TPS was conducted on a head and neck Rando phantom for 3D conformal radiotherapy (3DCRT) whole brain radiotherapy (WBRT) and volumetric modulated arc therapy (VMAT) meningioma planning in heterogeneous environments, using 12 TLD-100s and EBT3 Gafchromic films. Additionally, six Eclipse TPS patient plans were replicated on Monaco TPS, and PSQA was performed using gamma criteria of 3% dose difference (DD) and 3 mm distance-to-agreement (DTA). Results :Monaco TPS demonstrated consistent percentage deviations within ±10% (ranging from 1.8% to 9.1%) between TPS calculated and TLD-measured doses for 3DCRT, with no significant difference (p > 0.05). EBT3 Gafchromic film dosimetry showed good agreement with TPS dose distributions, achieving a 97.3% gamma passing rate. However, VMAT planning revealed significant deviations (3.06% to 67.88%) between calculated and measured doses, with a significant difference (p < 0.01) and a 52.5% gamma passing rate for film dosimetry. PSQA for six patient plans yielded high gamma passing rates (97.5% to 100%) and absolute dose deviations ranging from 0.29% to 3.48%.Conclusion : Monaco TPS is reliable and accurately commissioned for 3DCRT planning but shows significant deviations in VMAT planning. Future efforts should aim to improve verification methods, address challenges in gamma index analysis, and enhance VMAT dose calculation accuracy for consistent treatment planning.
format Thesis
author Azlan, Adriana Batrisyia Noor Mohd
author_facet Azlan, Adriana Batrisyia Noor Mohd
author_sort Azlan, Adriana Batrisyia Noor Mohd
title Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_short Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_full Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_fullStr Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_full_unstemmed Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_sort dosimetric verification of monaco treatment planning system (tps) in heterogeneous medium for 6 mv linac
publishDate 2024
url http://eprints.usm.my/61084/1/Adriana%20Batrisyia%20Noor%20Mohd%20Azlan-E.pdf
http://eprints.usm.my/61084/
_version_ 1814048425264545792
score 13.211869

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