Cover Image

Hypercoagulable state among thalassemia major patients

Increased incidence of thromboembolism among thalassemia patients had triggered various studies to determine hypercoagulable state among thalassemia patients. Several factors for the hypercoagulable state had been identified such as red blood cell membrane disruption, chronic platelet activation...

Full description

Saved in:
Bibliographic Details
Main Author: Hassan, Wan Amal Hayati Wan
Format: Thesis
Language:English
Published: 2013
Subjects:
R Medicine
RC31-1245 Internal medicine
RC648-665 Diseases of the endocrine glands. Clinical endocrinology
Online Access:http://eprints.usm.my/60849/1/DR%20WAN%20AMAL%20HAYATI%20BINTI%20WAN%20HASSAN%20-%20e.pdf
http://eprints.usm.my/60849/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usm.eprints.60849
record_format eprints
spelling my.usm.eprints.60849 http://eprints.usm.my/60849/ Hypercoagulable state among thalassemia major patients Hassan, Wan Amal Hayati Wan R Medicine RC31-1245 Internal medicine RC648-665 Diseases of the endocrine glands. Clinical endocrinology Increased incidence of thromboembolism among thalassemia patients had triggered various studies to determine hypercoagulable state among thalassemia patients. Several factors for the hypercoagulable state had been identified such as red blood cell membrane disruption, chronic platelet activation and defect in coagulation pathway. The objectives of this study were to determine the level of Protein C, Protein S and Antithrombin III among thalassemia major patients and to compare the level of these natural anticoagulants between thalassemia major patients and healthy controls. For this purpose, a case control study was conducted in Hospital Universiti Sains Malaysia (HUSM). Thirty six thalassemia patients who came for regular blood transfusion and twenty healthy blood donors for normal control were recruited. Blood samples were collected and analysed for Protein C, Protein S, Free Protein S and Antithrombin III using ACL Elite Pro coagulometer. The results showed mean Protein C, Protein S and Free Protein S levels were significantly lower in thalassemia patients (54.54 ± 13.22,94.41 ± 18.73 and 70.09 ± 12.32 ; respectively ) compared to normal controls (94.14 ± 16.34 , 105.12 ± 16.79 and 99.79 ± 17.33 ; respectively). Mean Antithrombin III showed no significant difference compared to normal controls (116.09 ± 27.28 and 124.36 ± 12.49 respectively). There were no significant differences of mean Protein C, Protein S, Free Protein S and Antithrombin III between splenectomised and non splenectomised patients. No thromboembolic events were documented in this study. In conclusion, significantly decreased Protein C and Protein S in thalassemia patients suggest hypercoagulable state in those patients. However further studies need to be done to look for other parameters contributing to hypercoagulable state in thalassemia patients. A normal antithrombin level could be due to protective effect of regular transfusion, a further study need to be done to prove this hypothesis. Besides, thromboembolic event can be subclinical, therefore a further study is needed to follow up the patients and to detect subclinical thrombosis. 2013-05 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60849/1/DR%20WAN%20AMAL%20HAYATI%20BINTI%20WAN%20HASSAN%20-%20e.pdf Hassan, Wan Amal Hayati Wan (2013) Hypercoagulable state among thalassemia major patients. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
RC31-1245 Internal medicine
RC648-665 Diseases of the endocrine glands. Clinical endocrinology
spellingShingle R Medicine
RC31-1245 Internal medicine
RC648-665 Diseases of the endocrine glands. Clinical endocrinology
Hassan, Wan Amal Hayati Wan
Hypercoagulable state among thalassemia major patients
description Increased incidence of thromboembolism among thalassemia patients had triggered various studies to determine hypercoagulable state among thalassemia patients. Several factors for the hypercoagulable state had been identified such as red blood cell membrane disruption, chronic platelet activation and defect in coagulation pathway. The objectives of this study were to determine the level of Protein C, Protein S and Antithrombin III among thalassemia major patients and to compare the level of these natural anticoagulants between thalassemia major patients and healthy controls. For this purpose, a case control study was conducted in Hospital Universiti Sains Malaysia (HUSM). Thirty six thalassemia patients who came for regular blood transfusion and twenty healthy blood donors for normal control were recruited. Blood samples were collected and analysed for Protein C, Protein S, Free Protein S and Antithrombin III using ACL Elite Pro coagulometer. The results showed mean Protein C, Protein S and Free Protein S levels were significantly lower in thalassemia patients (54.54 ± 13.22,94.41 ± 18.73 and 70.09 ± 12.32 ; respectively ) compared to normal controls (94.14 ± 16.34 , 105.12 ± 16.79 and 99.79 ± 17.33 ; respectively). Mean Antithrombin III showed no significant difference compared to normal controls (116.09 ± 27.28 and 124.36 ± 12.49 respectively). There were no significant differences of mean Protein C, Protein S, Free Protein S and Antithrombin III between splenectomised and non splenectomised patients. No thromboembolic events were documented in this study. In conclusion, significantly decreased Protein C and Protein S in thalassemia patients suggest hypercoagulable state in those patients. However further studies need to be done to look for other parameters contributing to hypercoagulable state in thalassemia patients. A normal antithrombin level could be due to protective effect of regular transfusion, a further study need to be done to prove this hypothesis. Besides, thromboembolic event can be subclinical, therefore a further study is needed to follow up the patients and to detect subclinical thrombosis.
format Thesis
author Hassan, Wan Amal Hayati Wan
author_facet Hassan, Wan Amal Hayati Wan
author_sort Hassan, Wan Amal Hayati Wan
title Hypercoagulable state among thalassemia major patients
title_short Hypercoagulable state among thalassemia major patients
title_full Hypercoagulable state among thalassemia major patients
title_fullStr Hypercoagulable state among thalassemia major patients
title_full_unstemmed Hypercoagulable state among thalassemia major patients
title_sort hypercoagulable state among thalassemia major patients
publishDate 2013
url http://eprints.usm.my/60849/1/DR%20WAN%20AMAL%20HAYATI%20BINTI%20WAN%20HASSAN%20-%20e.pdf
http://eprints.usm.my/60849/
_version_ 1816131387822964736
score 13.222552

Similar Items