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A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan

Childhood ITP is a hematological disorder with differs worldwide and has been a topic of debate. To evaluate the demographic, clinical characteristics, management practice and outcome of childhood ITP in Kelantan and explore the factors associated with development of chronic ITP. This study was co...

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Main Author: Daud, Rozaidahanim
Format: Thesis
Language:English
Published: 2013
Subjects:
R Medicine
RA440-440.87 Study and teaching. Research
RJ101 Child Health. Child health services
Online Access:http://eprints.usm.my/60842/1/DR%20ROZAIDAHANIM%20BINTI%20DAUD%20-%20e.pdf
http://eprints.usm.my/60842/
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spelling my.usm.eprints.60842 http://eprints.usm.my/60842/ A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan Daud, Rozaidahanim R Medicine RA440-440.87 Study and teaching. Research RJ101 Child Health. Child health services Childhood ITP is a hematological disorder with differs worldwide and has been a topic of debate. To evaluate the demographic, clinical characteristics, management practice and outcome of childhood ITP in Kelantan and explore the factors associated with development of chronic ITP. This study was conducted via retrospective record review in 2 major tertiary centres in Kelantan. It involved all newly diagnosed ITP cases aged 6 months to 18 years from January 2001 till September 2012 who met all the study criteria. There were 90 patients included in this study with the median age at diagnosis of 5.4 years old and equal gender distribution. A peak incidence of children with ITP was observed within 3 months after rainy season, from February to April. The lowest case recorded was from May to July, the driest months of the year. History of recent infectious illness was detected in 53.3% of cases. A total of 53.3% of cases presented with cutaneous bleeding manifestation while 46.7% had mucosa or mucocutaneous bleeding. No intracranial bleeding or death documented in the first 6 months of diagnosis. The median platelet count at diagnosis was 10 109/L with 50% of patient had giant platelets in FBP. BMA was performed in 12 patients. There were 85.6% (n=77) of patients who received active medical interventions either with specific agent, platelet transfusion or both while the remaining were managed expectantly during first 6 months of diagnosis. Active medical intervention did not affect the final outcome for these patients. Of these 90 patients, 66.7% were acute, 24.6% were chronic, and 8.9% were undetermined. Female gender and the presence of giant platelet in the FBP were shown to be associated with the development of chronic ITP. Generally, childhood ITP has a good clinical outcome and active medical intervention has not been shown to influence the final outcome of the disease. Female gender and presence of giant platelet are significant predictors towards chronic ITP. 2013 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60842/1/DR%20ROZAIDAHANIM%20BINTI%20DAUD%20-%20e.pdf Daud, Rozaidahanim (2013) A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
RA440-440.87 Study and teaching. Research
RJ101 Child Health. Child health services
spellingShingle R Medicine
RA440-440.87 Study and teaching. Research
RJ101 Child Health. Child health services
Daud, Rozaidahanim
A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan
description Childhood ITP is a hematological disorder with differs worldwide and has been a topic of debate. To evaluate the demographic, clinical characteristics, management practice and outcome of childhood ITP in Kelantan and explore the factors associated with development of chronic ITP. This study was conducted via retrospective record review in 2 major tertiary centres in Kelantan. It involved all newly diagnosed ITP cases aged 6 months to 18 years from January 2001 till September 2012 who met all the study criteria. There were 90 patients included in this study with the median age at diagnosis of 5.4 years old and equal gender distribution. A peak incidence of children with ITP was observed within 3 months after rainy season, from February to April. The lowest case recorded was from May to July, the driest months of the year. History of recent infectious illness was detected in 53.3% of cases. A total of 53.3% of cases presented with cutaneous bleeding manifestation while 46.7% had mucosa or mucocutaneous bleeding. No intracranial bleeding or death documented in the first 6 months of diagnosis. The median platelet count at diagnosis was 10 109/L with 50% of patient had giant platelets in FBP. BMA was performed in 12 patients. There were 85.6% (n=77) of patients who received active medical interventions either with specific agent, platelet transfusion or both while the remaining were managed expectantly during first 6 months of diagnosis. Active medical intervention did not affect the final outcome for these patients. Of these 90 patients, 66.7% were acute, 24.6% were chronic, and 8.9% were undetermined. Female gender and the presence of giant platelet in the FBP were shown to be associated with the development of chronic ITP. Generally, childhood ITP has a good clinical outcome and active medical intervention has not been shown to influence the final outcome of the disease. Female gender and presence of giant platelet are significant predictors towards chronic ITP.
format Thesis
author Daud, Rozaidahanim
author_facet Daud, Rozaidahanim
author_sort Daud, Rozaidahanim
title A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan
title_short A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan
title_full A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan
title_fullStr A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan
title_full_unstemmed A study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (ITP) in Kelantan
title_sort study on demography, clinical characteristics, management practice and outcome of childhood immune thrombocytopenia (itp) in kelantan
publishDate 2013
url http://eprints.usm.my/60842/1/DR%20ROZAIDAHANIM%20BINTI%20DAUD%20-%20e.pdf
http://eprints.usm.my/60842/
_version_ 1809137793702559744
score 13.211869

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