Cover Image

Association of laryngopharyngeal reflux (LPR) and central obesity

Laryngopharyngeal reflux (LPR) is a common disease encountered in otolaryngology. The presentation differs from gastroesophageal reflux disease (GERD) despite sharing similar pathophysiology. There are various postulated risk factors to LPR amongst which is central obesity. The aim of this study is...

Full description

Saved in:
Bibliographic Details
Main Author: Roy, Steuphen Roy A/L Peter Joseph
Format: Thesis
Language:English
Published: 2021
Subjects:
R Medicine
RA440-440.87 Study and teaching. Research
RF Otorhinolaryngology
Online Access:http://eprints.usm.my/60701/1/Soh%20Jien%20Yen-E.pdf
http://eprints.usm.my/60701/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usm.eprints.60701
record_format eprints
spelling my.usm.eprints.60701 http://eprints.usm.my/60701/ Association of laryngopharyngeal reflux (LPR) and central obesity Roy, Steuphen Roy A/L Peter Joseph R Medicine RA440-440.87 Study and teaching. Research RF Otorhinolaryngology Laryngopharyngeal reflux (LPR) is a common disease encountered in otolaryngology. The presentation differs from gastroesophageal reflux disease (GERD) despite sharing similar pathophysiology. There are various postulated risk factors to LPR amongst which is central obesity. The aim of this study is to establish central obesity as a risk factor in developing LPR. Methods This is a comparative cross-sectional study in which 180 patients who were 18 years old and above regardless of obesity status without confounding factors in causing laryngeal mucosal change such as smoking, malignancy, post nasal drip, treatment with proton pump inhibitors and pregnancy were enrolled. These patients were not diagnosed with LPR prior. No pH studies or empirical treatment with proton pump inhibitors were given before. Reflux symptom index (RSI) and reflux finding score (RFS) were used to screen for LPR sign and symptoms. Results 87 central-obese patients based on waist-to-hip ratio (0.9 and 0.85 for male and female respectively) and 93 non central-obese patients were recruited in this study. There was a significant higher value of both RSI and RFS in central-obese patients with significant positive correlation between these variables. Patients with central obesity might have a 2.6-fold higher probability of being diagnosed with LPR. Conclusion This study derived a linear correlation between central obesity and LPR based on the relatively simple and non-invasive RSI and RFS tool. 2021 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60701/1/Soh%20Jien%20Yen-E.pdf Roy, Steuphen Roy A/L Peter Joseph (2021) Association of laryngopharyngeal reflux (LPR) and central obesity. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
RA440-440.87 Study and teaching. Research
RF Otorhinolaryngology
spellingShingle R Medicine
RA440-440.87 Study and teaching. Research
RF Otorhinolaryngology
Roy, Steuphen Roy A/L Peter Joseph
Association of laryngopharyngeal reflux (LPR) and central obesity
description Laryngopharyngeal reflux (LPR) is a common disease encountered in otolaryngology. The presentation differs from gastroesophageal reflux disease (GERD) despite sharing similar pathophysiology. There are various postulated risk factors to LPR amongst which is central obesity. The aim of this study is to establish central obesity as a risk factor in developing LPR. Methods This is a comparative cross-sectional study in which 180 patients who were 18 years old and above regardless of obesity status without confounding factors in causing laryngeal mucosal change such as smoking, malignancy, post nasal drip, treatment with proton pump inhibitors and pregnancy were enrolled. These patients were not diagnosed with LPR prior. No pH studies or empirical treatment with proton pump inhibitors were given before. Reflux symptom index (RSI) and reflux finding score (RFS) were used to screen for LPR sign and symptoms. Results 87 central-obese patients based on waist-to-hip ratio (0.9 and 0.85 for male and female respectively) and 93 non central-obese patients were recruited in this study. There was a significant higher value of both RSI and RFS in central-obese patients with significant positive correlation between these variables. Patients with central obesity might have a 2.6-fold higher probability of being diagnosed with LPR. Conclusion This study derived a linear correlation between central obesity and LPR based on the relatively simple and non-invasive RSI and RFS tool.
format Thesis
author Roy, Steuphen Roy A/L Peter Joseph
author_facet Roy, Steuphen Roy A/L Peter Joseph
author_sort Roy, Steuphen Roy A/L Peter Joseph
title Association of laryngopharyngeal reflux (LPR) and central obesity
title_short Association of laryngopharyngeal reflux (LPR) and central obesity
title_full Association of laryngopharyngeal reflux (LPR) and central obesity
title_fullStr Association of laryngopharyngeal reflux (LPR) and central obesity
title_full_unstemmed Association of laryngopharyngeal reflux (LPR) and central obesity
title_sort association of laryngopharyngeal reflux (lpr) and central obesity
publishDate 2021
url http://eprints.usm.my/60701/1/Soh%20Jien%20Yen-E.pdf
http://eprints.usm.my/60701/
_version_ 1806443592896479232
score 13.251813

Similar Items