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The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum

An attenuated strain of Mycobacterium bow's BCG is the only available vaccine used for tuberculosis so far. The presence of glycolipids such as lipoarabinomannan (LAM) and lipomannan (LM) in its cell wall has encouraged the use of BCG as a recombinant vaccine vector for other pathogens, incl...

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Main Author: Rajendran, Sasirekha D/O
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2015
Subjects:
R Medicine
RA440-440.87 Study and teaching. Research
Online Access:http://eprints.usm.my/60560/1/SASIREKHA%20DO%20RAJENDRAN%20-%20e.pdf
http://eprints.usm.my/60560/
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spelling my.usm.eprints.60560 http://eprints.usm.my/60560/ The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum Rajendran, Sasirekha D/O R Medicine RA440-440.87 Study and teaching. Research An attenuated strain of Mycobacterium bow's BCG is the only available vaccine used for tuberculosis so far. The presence of glycolipids such as lipoarabinomannan (LAM) and lipomannan (LM) in its cell wall has encouraged the use of BCG as a recombinant vaccine vector for other pathogens, including malaria parasites. The benefits of using BCG as a recombinant vaccine vector include its ability to be ingested by professional antigen presenting cells (APCs) such as macrophage to induce pro-inflammatory responses, an important innate host defense mechanism against malaria infection. The interaction between BCG and macrophage involves several toll like receptors (TLRs) such as TLR-2. Therefore, this study was conducted to determine the role of TLR-2 in the production of inflammatory cytokines such as TNF-a and IL-10 by murine macrophage cell line, .I774A.1 infected with BCG and recombinant BCG (rBCG) clones expressing the MSP-1C of Plasmodium falciparum Universiti Sains Malaysia 2015 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/60560/1/SASIREKHA%20DO%20RAJENDRAN%20-%20e.pdf Rajendran, Sasirekha D/O (2015) The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum. Project Report. Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
RA440-440.87 Study and teaching. Research
spellingShingle R Medicine
RA440-440.87 Study and teaching. Research
Rajendran, Sasirekha D/O
The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum
description An attenuated strain of Mycobacterium bow's BCG is the only available vaccine used for tuberculosis so far. The presence of glycolipids such as lipoarabinomannan (LAM) and lipomannan (LM) in its cell wall has encouraged the use of BCG as a recombinant vaccine vector for other pathogens, including malaria parasites. The benefits of using BCG as a recombinant vaccine vector include its ability to be ingested by professional antigen presenting cells (APCs) such as macrophage to induce pro-inflammatory responses, an important innate host defense mechanism against malaria infection. The interaction between BCG and macrophage involves several toll like receptors (TLRs) such as TLR-2. Therefore, this study was conducted to determine the role of TLR-2 in the production of inflammatory cytokines such as TNF-a and IL-10 by murine macrophage cell line, .I774A.1 infected with BCG and recombinant BCG (rBCG) clones expressing the MSP-1C of Plasmodium falciparum
format Monograph
author Rajendran, Sasirekha D/O
author_facet Rajendran, Sasirekha D/O
author_sort Rajendran, Sasirekha D/O
title The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum
title_short The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum
title_full The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum
title_fullStr The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum
title_full_unstemmed The role of TLR-2 IN the production of TNF-a and IL-10 by macrophage infected with a recombinant BCG (rBCG) expressing the MSP-1COF Plasmodium falciparum
title_sort role of tlr-2 in the production of tnf-a and il-10 by macrophage infected with a recombinant bcg (rbcg) expressing the msp-1cof plasmodium falciparum
publisher Universiti Sains Malaysia
publishDate 2015
url http://eprints.usm.my/60560/1/SASIREKHA%20DO%20RAJENDRAN%20-%20e.pdf
http://eprints.usm.my/60560/
_version_ 1800086048904052736
score 13.211869

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