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Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients

The human angiotensin-1 converting enzyme (ACE) gene contains an insertion or deletion (I/D) of Alu repeat element in intron 16 of the chromosome 17 (17q23). This polymorphism has been widely investigated to determine its effects in causing ischemic stroke but inconsistent results are obtained. T...

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Main Author: Pei, Cheung Tian
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2012
Subjects:
RC Internal medicine
Online Access:http://eprints.usm.my/59590/1/CHEUNG%20TIAN%20PEI%20-%20e.pdf
http://eprints.usm.my/59590/
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spelling my.usm.eprints.59590 http://eprints.usm.my/59590/ Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients Pei, Cheung Tian RC Internal medicine The human angiotensin-1 converting enzyme (ACE) gene contains an insertion or deletion (I/D) of Alu repeat element in intron 16 of the chromosome 17 (17q23). This polymorphism has been widely investigated to determine its effects in causing ischemic stroke but inconsistent results are obtained. Thus, this study aims to genotype the ACE I/D polymorphism to determine its genotypic frequency among Malay ischemic stroke patients. The study subjects comprised of 27 Malay ischemic stroke patients that were recruited from HUSM. ACE I/D gene polymorphism was determined by genotyping the SNP rs4341 polymorphism using PCR-RFLP method. The frequencies of ACE polymorphism (II, ID and DD genotypes) were determined and presented in the form of percentage. The results showed that ACE II genotype was present in all Malay ischemic stroke patients (100%) while ID and DD genotypes did not make any contribution to the genotypic frequency. Therefore, the ACE II genotype is responsible for the occurrence of ischemic stroke among Malay stroke patients. However, the result is a preliminary finding in which larger and extensive studies can be performed based on it. Universiti Sains Malaysia 2012 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/59590/1/CHEUNG%20TIAN%20PEI%20-%20e.pdf Pei, Cheung Tian (2012) Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients. Project Report. Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
Pei, Cheung Tian
Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients
description The human angiotensin-1 converting enzyme (ACE) gene contains an insertion or deletion (I/D) of Alu repeat element in intron 16 of the chromosome 17 (17q23). This polymorphism has been widely investigated to determine its effects in causing ischemic stroke but inconsistent results are obtained. Thus, this study aims to genotype the ACE I/D polymorphism to determine its genotypic frequency among Malay ischemic stroke patients. The study subjects comprised of 27 Malay ischemic stroke patients that were recruited from HUSM. ACE I/D gene polymorphism was determined by genotyping the SNP rs4341 polymorphism using PCR-RFLP method. The frequencies of ACE polymorphism (II, ID and DD genotypes) were determined and presented in the form of percentage. The results showed that ACE II genotype was present in all Malay ischemic stroke patients (100%) while ID and DD genotypes did not make any contribution to the genotypic frequency. Therefore, the ACE II genotype is responsible for the occurrence of ischemic stroke among Malay stroke patients. However, the result is a preliminary finding in which larger and extensive studies can be performed based on it.
format Monograph
author Pei, Cheung Tian
author_facet Pei, Cheung Tian
author_sort Pei, Cheung Tian
title Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients
title_short Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients
title_full Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients
title_fullStr Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients
title_full_unstemmed Genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients
title_sort genotyping of angiotensin-1 converting enzyme insertion/deletion gene polymorphism in malay ischemic stroke patients
publisher Universiti Sains Malaysia
publishDate 2012
url http://eprints.usm.my/59590/1/CHEUNG%20TIAN%20PEI%20-%20e.pdf
http://eprints.usm.my/59590/
_version_ 1783877485140639744
score 13.211869

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