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Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit

The objective of the study is to find how the interactions erythromycin A (ERYA), a 14-membered ring macrolide, with a single base substitution from adenine to guanine on the large ribosomal subunit at 2041. This single base substitution has been reported of to be one of the resistance modes in the...

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Main Author: Mohamad Zobir, Siti Zuraidah
Format: Thesis
Language:English
Published: 2012
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/59483/1/Siti%20Zuraidah%20binti%20Mohamad%20Zobir%20cut.pdf
http://eprints.usm.my/59483/
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spelling my.usm.eprints.59483 http://eprints.usm.my/59483/ Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit Mohamad Zobir, Siti Zuraidah RS1-441 Pharmacy and materia medica The objective of the study is to find how the interactions erythromycin A (ERYA), a 14-membered ring macrolide, with a single base substitution from adenine to guanine on the large ribosomal subunit at 2041. This single base substitution has been reported of to be one of the resistance modes in the binding of macrolides. Molecular dynamics (MD) simulation is a great tool that was used in this study to explain at the molecular level why resistance happens when a single base substitution takes place at 2041, one of the residues in PTe. 2012-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/59483/1/Siti%20Zuraidah%20binti%20Mohamad%20Zobir%20cut.pdf Mohamad Zobir, Siti Zuraidah (2012) Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Mohamad Zobir, Siti Zuraidah
Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit
description The objective of the study is to find how the interactions erythromycin A (ERYA), a 14-membered ring macrolide, with a single base substitution from adenine to guanine on the large ribosomal subunit at 2041. This single base substitution has been reported of to be one of the resistance modes in the binding of macrolides. Molecular dynamics (MD) simulation is a great tool that was used in this study to explain at the molecular level why resistance happens when a single base substitution takes place at 2041, one of the residues in PTe.
format Thesis
author Mohamad Zobir, Siti Zuraidah
author_facet Mohamad Zobir, Siti Zuraidah
author_sort Mohamad Zobir, Siti Zuraidah
title Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit
title_short Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit
title_full Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit
title_fullStr Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit
title_full_unstemmed Molecular Dynamics Studies: The Interaction Of Erythromycin A With A Single Base Substitution Of 50s Ribosomal Subunit
title_sort molecular dynamics studies: the interaction of erythromycin a with a single base substitution of 50s ribosomal subunit
publishDate 2012
url http://eprints.usm.my/59483/1/Siti%20Zuraidah%20binti%20Mohamad%20Zobir%20cut.pdf
http://eprints.usm.my/59483/
_version_ 1781705439079038976
score 13.211869

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