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Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis

The occurance of counterfeit paracetamol (PCM) in consumer market persist, meaning there could be some of the PCM sold may contain no active ingredients and no therapeutic benefits to consumer. A rapid, precise and simple of spectrophotometric method using UV-Vis analysis was used for the determi...

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Main Author: Mukhtar, Farah Hanim
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2015
Subjects:
RS Pharmacy and materia medica
Online Access:http://eprints.usm.my/59079/1/FARAH%20HANIM%20BINTI%20MUKHTAR%20-%20e24.pdf
http://eprints.usm.my/59079/
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spelling my.usm.eprints.59079 http://eprints.usm.my/59079/ Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis Mukhtar, Farah Hanim RS Pharmacy and materia medica The occurance of counterfeit paracetamol (PCM) in consumer market persist, meaning there could be some of the PCM sold may contain no active ingredients and no therapeutic benefits to consumer. A rapid, precise and simple of spectrophotometric method using UV-Vis analysis was used for the determination of concentration of paracetamol (PCM) from assay of PCM in tablet formulation. The method used have been developed and validated for the assay of PCM using methanol and water as The maximum diluents. wavelength reading (X™ax) are measured at 244 nm. The percentage recoveries were found to range from 97.92 to 104.72. This method was applied to determine the quantity of 21 sample from different brand which available over the counter (OTC) shop and pharmacies from four location. Based on percent of sample recovery, all the sample are considered as authentic due to quantity of active ingredient PCM almost same with the stated dosage. The chemometris analysis such as principle component analysis, (PCA) and hierarchical cluster analysis, (HCA) was used to classify sample into three clusters, A, B and C, and clustering was found to be based on type of PCM tablet. Universiti Sains Malaysia 2015 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/59079/1/FARAH%20HANIM%20BINTI%20MUKHTAR%20-%20e24.pdf Mukhtar, Farah Hanim (2015) Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis. Project Report. Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Mukhtar, Farah Hanim
Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis
description The occurance of counterfeit paracetamol (PCM) in consumer market persist, meaning there could be some of the PCM sold may contain no active ingredients and no therapeutic benefits to consumer. A rapid, precise and simple of spectrophotometric method using UV-Vis analysis was used for the determination of concentration of paracetamol (PCM) from assay of PCM in tablet formulation. The method used have been developed and validated for the assay of PCM using methanol and water as The maximum diluents. wavelength reading (X™ax) are measured at 244 nm. The percentage recoveries were found to range from 97.92 to 104.72. This method was applied to determine the quantity of 21 sample from different brand which available over the counter (OTC) shop and pharmacies from four location. Based on percent of sample recovery, all the sample are considered as authentic due to quantity of active ingredient PCM almost same with the stated dosage. The chemometris analysis such as principle component analysis, (PCA) and hierarchical cluster analysis, (HCA) was used to classify sample into three clusters, A, B and C, and clustering was found to be based on type of PCM tablet.
format Monograph
author Mukhtar, Farah Hanim
author_facet Mukhtar, Farah Hanim
author_sort Mukhtar, Farah Hanim
title Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis
title_short Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis
title_full Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis
title_fullStr Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis
title_full_unstemmed Counterfeit Tablet Investigation for Paracetamol Contents in Over the Counter Formulations Using UV-Visible Spectrophotometer Analysis
title_sort counterfeit tablet investigation for paracetamol contents in over the counter formulations using uv-visible spectrophotometer analysis
publisher Universiti Sains Malaysia
publishDate 2015
url http://eprints.usm.my/59079/1/FARAH%20HANIM%20BINTI%20MUKHTAR%20-%20e24.pdf
http://eprints.usm.my/59079/
_version_ 1775623420066660352
score 13.211869

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