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Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana

Garcinia mangostana is a tropical plant found commonly in South East Asia. This plant possesses anti-inflammatory, antibacterial, antiulcer, antiseptic effects and showed prevention against oxidative damage of low-density lipoprotein cholesterol (LDL-C). The present study aimed to evaluate the an...

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Main Author: Manogaran, Manimegalai
Format: Thesis
Language:English
Published: 2016
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/57506/1/00001802887%20Manimegalai%20Manogaran.pdf
http://eprints.usm.my/57506/
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spelling my.usm.eprints.57506 http://eprints.usm.my/57506/ Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana Manogaran, Manimegalai RS1-441 Pharmacy and materia medica Garcinia mangostana is a tropical plant found commonly in South East Asia. This plant possesses anti-inflammatory, antibacterial, antiulcer, antiseptic effects and showed prevention against oxidative damage of low-density lipoprotein cholesterol (LDL-C). The present study aimed to evaluate the antioxidant and antihyperlipidemic activities as well as phytochemical analysis of methanolic and aqueous extracts of various parts of leaves of G. mangostana, namely leaves, stem, bark, hull, petals, stalk, seed and flesh. The highest phenolic content was found in methanolic (41.74 ug GAE/g) and aqueous (11.29 ug GAE/g) extracts of leaves. Leaves extracts also showed highest flavonoid content of 31.80 ug GAE/g in methanolic and 19.48 ug GAE/g in aqueous extracts. For ferric reducing antioxidant power (FRAP), both methanolic and aqueous extracts of leaves showed most potent activity ofO.4S ± 0.01 urnol Fe2+/g and 0.39 ± 0.09 umol Fe2+/g respectively while u-mangostin possessed low FRAP activity compared to the extracts. Methanolic extract of stalk showed highest 2,2-diphenyl-l-picrylhydrazyl (DPPH) radical scavenging activity with ECso of 3.36 ± 0.52 ug/ml, while aqueous extract of leaves showed ECso of 3.21 ± 0.57 J.1g/mL compared to 0.- mangostin which had ECso of 4.03 ± 0.87 ug/ml., For 2,2- azinobis (3-ethyl- benzothiazolin-6-sulfate acid) (ABTS) radical scavenging activity, methanolic extract of stem and aqueous extract of leaves showed highest activity with ECso of 0.78 ± 0.45 J.1g/mL and 0.81 ± 0.37 ug/ml., respectively plus 0.mangostin had ECso of 2.88 ± 0.55 J.1g/mL. 2016-04 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/57506/1/00001802887%20Manimegalai%20Manogaran.pdf Manogaran, Manimegalai (2016) Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana. Masters thesis, Perpustakaan Hamzah Sendut.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Manogaran, Manimegalai
Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana
description Garcinia mangostana is a tropical plant found commonly in South East Asia. This plant possesses anti-inflammatory, antibacterial, antiulcer, antiseptic effects and showed prevention against oxidative damage of low-density lipoprotein cholesterol (LDL-C). The present study aimed to evaluate the antioxidant and antihyperlipidemic activities as well as phytochemical analysis of methanolic and aqueous extracts of various parts of leaves of G. mangostana, namely leaves, stem, bark, hull, petals, stalk, seed and flesh. The highest phenolic content was found in methanolic (41.74 ug GAE/g) and aqueous (11.29 ug GAE/g) extracts of leaves. Leaves extracts also showed highest flavonoid content of 31.80 ug GAE/g in methanolic and 19.48 ug GAE/g in aqueous extracts. For ferric reducing antioxidant power (FRAP), both methanolic and aqueous extracts of leaves showed most potent activity ofO.4S ± 0.01 urnol Fe2+/g and 0.39 ± 0.09 umol Fe2+/g respectively while u-mangostin possessed low FRAP activity compared to the extracts. Methanolic extract of stalk showed highest 2,2-diphenyl-l-picrylhydrazyl (DPPH) radical scavenging activity with ECso of 3.36 ± 0.52 ug/ml, while aqueous extract of leaves showed ECso of 3.21 ± 0.57 J.1g/mL compared to 0.- mangostin which had ECso of 4.03 ± 0.87 ug/ml., For 2,2- azinobis (3-ethyl- benzothiazolin-6-sulfate acid) (ABTS) radical scavenging activity, methanolic extract of stem and aqueous extract of leaves showed highest activity with ECso of 0.78 ± 0.45 J.1g/mL and 0.81 ± 0.37 ug/ml., respectively plus 0.mangostin had ECso of 2.88 ± 0.55 J.1g/mL.
format Thesis
author Manogaran, Manimegalai
author_facet Manogaran, Manimegalai
author_sort Manogaran, Manimegalai
title Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana
title_short Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana
title_full Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana
title_fullStr Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana
title_full_unstemmed Analysis Of Phytochemicals, Antioxidant And Antihyperlipidemic Activities Of Methanolic And Aqueous Extracts Of Various Parts Of Garcinia Mangostana
title_sort analysis of phytochemicals, antioxidant and antihyperlipidemic activities of methanolic and aqueous extracts of various parts of garcinia mangostana
publishDate 2016
url http://eprints.usm.my/57506/1/00001802887%20Manimegalai%20Manogaran.pdf
http://eprints.usm.my/57506/
_version_ 1761617409166278656
score 13.211869

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