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A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients

Type 2 Diabetes Mellitus (DM) is a chronic disease with many complications. Among the well-known complications are nephropathy, neuropathy, and retinopathy. A complication which is rarely looked upon is cognitive impairment which is recently being highly associated with diabetes mellitus. There are...

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Main Author: Nair, V. Rubini
Format: Thesis
Language:English
Published: 2020
Subjects:
RA643-645 Disease (Communicable and noninfectious) and public health
RC31-1245 Internal medicine
Online Access:http://eprints.usm.my/56968/1/V.RUBINI%20NAIR%20-%20e%2024.pdf
http://eprints.usm.my/56968/
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spelling my.usm.eprints.56968 http://eprints.usm.my/56968/ A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients Nair, V. Rubini RA643-645 Disease (Communicable and noninfectious) and public health RC31-1245 Internal medicine Type 2 Diabetes Mellitus (DM) is a chronic disease with many complications. Among the well-known complications are nephropathy, neuropathy, and retinopathy. A complication which is rarely looked upon is cognitive impairment which is recently being highly associated with diabetes mellitus. There are a few recent publications which revealed that cognitive impairment and peripheral neuropathy could be brought about by a similar pathophysiology. A total of 279 diabetes mellitus patients were recruited from a diabetes clinic in Hospital Universiti Sains Malaysia from the 1st of July, 2018 until the 30th of September, 2019. Demographic, clinical and laboratory data were recorded from the patients’ file. Cognitive impairment was assessed by the Montreal Cognitive Assessment (MOCA) and peripheral neuropathy was assessed by Michigan Neuropathy Screening Instrument (MNSI). The association between peripheral neuropathy and cognitive impairment was analysed using simple and multiple logistic regression method. A total of 279 patients were included in this study. The mean age of the patients was 62.38 (SD 8.53) years old. The mean duration of diabetes mellitus was 9.59 (SD 5.53) years. Majority of them were females, n=206 (73.8%). All of them were married and 97.5% were Malays. 183 patients (65.6%) had peripheral neuropathy while 196 patients (70.3%) experienced cognitive impairment. There was a significant association between peripheral neuropathy and cognitive impairment (p<0.001). Half of the patients with peripheral neuropathy had concomitantcognitive impairment (n=141, 50.5%). There was also a significant association of gender in which females conferred 74% lower odds to experience cognitive impairment compared to males (p<0.001). For patients with hyperlipidaemia, there were 2.07 times odds to experience cognitive impairment as compared to patients without hyperlipidaemia (p=0.046). For patients with retinopathy, there were 2.14 times odds to experience cognitive impairment as compared to patients without retinopathy (p=0.008). There was a significant association between the development of cognitive impairment among diabetes mellitus patients with a peripheral neuropathy. Female gender was associated with lower risk of cognitive impairment as compared to male. DM patients with dyslipidaemia and diabetic retinopathy have a higher risk of developing cognitive impairment. 2020 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/56968/1/V.RUBINI%20NAIR%20-%20e%2024.pdf Nair, V. Rubini (2020) A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RA643-645 Disease (Communicable and noninfectious) and public health
RC31-1245 Internal medicine
spellingShingle RA643-645 Disease (Communicable and noninfectious) and public health
RC31-1245 Internal medicine
Nair, V. Rubini
A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients
description Type 2 Diabetes Mellitus (DM) is a chronic disease with many complications. Among the well-known complications are nephropathy, neuropathy, and retinopathy. A complication which is rarely looked upon is cognitive impairment which is recently being highly associated with diabetes mellitus. There are a few recent publications which revealed that cognitive impairment and peripheral neuropathy could be brought about by a similar pathophysiology. A total of 279 diabetes mellitus patients were recruited from a diabetes clinic in Hospital Universiti Sains Malaysia from the 1st of July, 2018 until the 30th of September, 2019. Demographic, clinical and laboratory data were recorded from the patients’ file. Cognitive impairment was assessed by the Montreal Cognitive Assessment (MOCA) and peripheral neuropathy was assessed by Michigan Neuropathy Screening Instrument (MNSI). The association between peripheral neuropathy and cognitive impairment was analysed using simple and multiple logistic regression method. A total of 279 patients were included in this study. The mean age of the patients was 62.38 (SD 8.53) years old. The mean duration of diabetes mellitus was 9.59 (SD 5.53) years. Majority of them were females, n=206 (73.8%). All of them were married and 97.5% were Malays. 183 patients (65.6%) had peripheral neuropathy while 196 patients (70.3%) experienced cognitive impairment. There was a significant association between peripheral neuropathy and cognitive impairment (p<0.001). Half of the patients with peripheral neuropathy had concomitantcognitive impairment (n=141, 50.5%). There was also a significant association of gender in which females conferred 74% lower odds to experience cognitive impairment compared to males (p<0.001). For patients with hyperlipidaemia, there were 2.07 times odds to experience cognitive impairment as compared to patients without hyperlipidaemia (p=0.046). For patients with retinopathy, there were 2.14 times odds to experience cognitive impairment as compared to patients without retinopathy (p=0.008). There was a significant association between the development of cognitive impairment among diabetes mellitus patients with a peripheral neuropathy. Female gender was associated with lower risk of cognitive impairment as compared to male. DM patients with dyslipidaemia and diabetic retinopathy have a higher risk of developing cognitive impairment.
format Thesis
author Nair, V. Rubini
author_facet Nair, V. Rubini
author_sort Nair, V. Rubini
title A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients
title_short A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients
title_full A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients
title_fullStr A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients
title_full_unstemmed A study of an association between peripheral neuropathy and cognitive impairment in Type 2 Diabetes Mellitus patients
title_sort study of an association between peripheral neuropathy and cognitive impairment in type 2 diabetes mellitus patients
publishDate 2020
url http://eprints.usm.my/56968/1/V.RUBINI%20NAIR%20-%20e%2024.pdf
http://eprints.usm.my/56968/
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score 13.211869

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