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Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery

The application of chitosan has received enormous attention in medical field particularly in drug delivery. In this study, chitosan with two monomers, methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) were prepared by emulsion polymerization to form a chitosan-poly(methacrylic acid-co-N-isopr...

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Main Author: Md Rasib, Siti Zalifah
Format: Thesis
Language:English
Published: 2019
Subjects:
T Technology
TN Mining Engineering. Metallurgy
Online Access:http://eprints.usm.my/56156/1/Synthesis%2C%20Characterization%20And%20Properties%20Of%20Chitosan-Poly%20%28Methacrylic%20Acid-Co-N-Isopropylacrylamide%29%20Hydrogel%20For%20Drug%20Delivery_Siti%20Zalifah%20Md%20Rasib.pdf
http://eprints.usm.my/56156/
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spelling my.usm.eprints.56156 http://eprints.usm.my/56156/ Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery Md Rasib, Siti Zalifah T Technology TN Mining Engineering. Metallurgy The application of chitosan has received enormous attention in medical field particularly in drug delivery. In this study, chitosan with two monomers, methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) were prepared by emulsion polymerization to form a chitosan-poly(methacrylic acid-co-N-isopropylacrylamide) (chitosan-p(MAA-co-NIPAM)) hydrogel as a drug carrier. Hydrogels were characterized using Fourier Transform Infrared (FTIR) Spectroscopy, Carbon-13 Nuclear Magnetic Resonance (13C-NMR), Field Emission Scanning Electron Microscope (FESEM), particle size analysis and Dynamic Light Scattering (DLS). The effect of stimuli responsive (pH and temperature), hydrolysis, drug loading, in-vitro drug release and cytotoxicity was investigated. The finding found that chitosan-p(MAA-co-NIPAM) hydrogel synthesized using surfactant (Span 80) successfully achieved particle size less than 500 nm. The cationic surface charge of synthesis hydrogel passed the stability requirement to avoid aggregation in blood system above 30 mV at pH 3 to 5 and potentially enhanced cellular internalization drug delivery up to pH 6. The release of Rifampicin drug was controlled by combination of diffusion and swelling as the drug released was prolonged to 72 hours indicating that the hydrogel responded to the pH and temperature environment. High viability cell from cytotoxicity assessment demonstrated that the hydrogels are human/animal friendly biomaterials. Thus, it can be concluded that chitosan-p(MAA-co-NIPAM) hydrogels are feasible as controlled drug delivery carrier. 2019-05-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/56156/1/Synthesis%2C%20Characterization%20And%20Properties%20Of%20Chitosan-Poly%20%28Methacrylic%20Acid-Co-N-Isopropylacrylamide%29%20Hydrogel%20For%20Drug%20Delivery_Siti%20Zalifah%20Md%20Rasib.pdf Md Rasib, Siti Zalifah (2019) Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic T Technology
TN Mining Engineering. Metallurgy
spellingShingle T Technology
TN Mining Engineering. Metallurgy
Md Rasib, Siti Zalifah
Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
description The application of chitosan has received enormous attention in medical field particularly in drug delivery. In this study, chitosan with two monomers, methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) were prepared by emulsion polymerization to form a chitosan-poly(methacrylic acid-co-N-isopropylacrylamide) (chitosan-p(MAA-co-NIPAM)) hydrogel as a drug carrier. Hydrogels were characterized using Fourier Transform Infrared (FTIR) Spectroscopy, Carbon-13 Nuclear Magnetic Resonance (13C-NMR), Field Emission Scanning Electron Microscope (FESEM), particle size analysis and Dynamic Light Scattering (DLS). The effect of stimuli responsive (pH and temperature), hydrolysis, drug loading, in-vitro drug release and cytotoxicity was investigated. The finding found that chitosan-p(MAA-co-NIPAM) hydrogel synthesized using surfactant (Span 80) successfully achieved particle size less than 500 nm. The cationic surface charge of synthesis hydrogel passed the stability requirement to avoid aggregation in blood system above 30 mV at pH 3 to 5 and potentially enhanced cellular internalization drug delivery up to pH 6. The release of Rifampicin drug was controlled by combination of diffusion and swelling as the drug released was prolonged to 72 hours indicating that the hydrogel responded to the pH and temperature environment. High viability cell from cytotoxicity assessment demonstrated that the hydrogels are human/animal friendly biomaterials. Thus, it can be concluded that chitosan-p(MAA-co-NIPAM) hydrogels are feasible as controlled drug delivery carrier.
format Thesis
author Md Rasib, Siti Zalifah
author_facet Md Rasib, Siti Zalifah
author_sort Md Rasib, Siti Zalifah
title Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_short Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_full Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_fullStr Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_full_unstemmed Synthesis, Characterization And Properties Of Chitosan-Poly (Methacrylic Acid-Co-N-Isopropylacrylamide) Hydrogel For Drug Delivery
title_sort synthesis, characterization and properties of chitosan-poly (methacrylic acid-co-n-isopropylacrylamide) hydrogel for drug delivery
publishDate 2019
url http://eprints.usm.my/56156/1/Synthesis%2C%20Characterization%20And%20Properties%20Of%20Chitosan-Poly%20%28Methacrylic%20Acid-Co-N-Isopropylacrylamide%29%20Hydrogel%20For%20Drug%20Delivery_Siti%20Zalifah%20Md%20Rasib.pdf
http://eprints.usm.my/56156/
_version_ 1753789247682248704
score 13.211869

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