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Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study

Centel/a Asiatica has a reputation to restore declining cognitive function in traditional medicine. In this study, asiatic acid from triterpenoids groups isolated from C. asiatica were examined for in vitro Thin Layer Chromatography (TLC) by bioautographic acetylcholinesterase inhibitory activity,...

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Main Author: Abd Rahman, Izani Ghani
Format: Monograph
Language:English
Published: Pusat Pengajian Sains Perubatan
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/55348/1/DR%20WAN%20AZMAN%20WAN%20SULAIMAN%20-%20e.pdf
http://eprints.usm.my/55348/
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spelling my.usm.eprints.55348 http://eprints.usm.my/55348/ Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study Abd Rahman, Izani Ghani R Medicine (General) Centel/a Asiatica has a reputation to restore declining cognitive function in traditional medicine. In this study, asiatic acid from triterpenoids groups isolated from C. asiatica were examined for in vitro Thin Layer Chromatography (TLC) by bioautographic acetylcholinesterase inhibitory activity, in vivo psycopharmacology of excitatory post synaptic potential (EPSP} on the rat hippocampus and in vivo learning and memory potential as well as study of mechanism to the blood pressure with locomotors activities. This study is consistent with asiatic acid which having an effect on TLC bioautographic acetylcholinesterase inhibitory activity with minimal inhibition concentration, 0.125 llll· In vivo psycopharmacology of EPSP was shown selectively to GABA B receptor agonist. Then the inhibitory concentration was plotted using psycopharmacology of EPSP results with half maximal inhibitory concentration was 14 11M with Hill-Coefficient 0.9828. The in vivo learning and memory potential were performed using passive and active avoidance devices. Administration of asiatic acid facilitated on passive avoidance on memory but had no effect on active avoidance on learning. Study on mechanism to the blood pressure with locomotors performances shown that 10 dan 30 mg/k:g asiatic acid less effect in blood pressure and no sedative effect on locomotor performance. Pusat Pengajian Sains Perubatan Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/55348/1/DR%20WAN%20AZMAN%20WAN%20SULAIMAN%20-%20e.pdf Abd Rahman, Izani Ghani Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study. Other. Pusat Pengajian Sains Perubatan. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Abd Rahman, Izani Ghani
Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study
description Centel/a Asiatica has a reputation to restore declining cognitive function in traditional medicine. In this study, asiatic acid from triterpenoids groups isolated from C. asiatica were examined for in vitro Thin Layer Chromatography (TLC) by bioautographic acetylcholinesterase inhibitory activity, in vivo psycopharmacology of excitatory post synaptic potential (EPSP} on the rat hippocampus and in vivo learning and memory potential as well as study of mechanism to the blood pressure with locomotors activities. This study is consistent with asiatic acid which having an effect on TLC bioautographic acetylcholinesterase inhibitory activity with minimal inhibition concentration, 0.125 llll· In vivo psycopharmacology of EPSP was shown selectively to GABA B receptor agonist. Then the inhibitory concentration was plotted using psycopharmacology of EPSP results with half maximal inhibitory concentration was 14 11M with Hill-Coefficient 0.9828. The in vivo learning and memory potential were performed using passive and active avoidance devices. Administration of asiatic acid facilitated on passive avoidance on memory but had no effect on active avoidance on learning. Study on mechanism to the blood pressure with locomotors performances shown that 10 dan 30 mg/k:g asiatic acid less effect in blood pressure and no sedative effect on locomotor performance.
format Monograph
author Abd Rahman, Izani Ghani
author_facet Abd Rahman, Izani Ghani
author_sort Abd Rahman, Izani Ghani
title Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study
title_short Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study
title_full Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study
title_fullStr Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study
title_full_unstemmed Psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study
title_sort psychopharmacology of asiatic acid from centella asiatica :in vitro and in vivo study
publisher Pusat Pengajian Sains Perubatan
url http://eprints.usm.my/55348/1/DR%20WAN%20AZMAN%20WAN%20SULAIMAN%20-%20e.pdf
http://eprints.usm.my/55348/
_version_ 1748181587763134464
score 13.211869

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