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Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser

The laser applications on blood helps to elucidates the interaction mechanisms of laser light with blood (biological tissues). The knowledge of blood dielectric response, biostimulation effects and specific absorption rate (SAR) through electrical impedance spectroscopy can optimise appropriate medi...

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Main Author: Gemanam, Sylvester Jande
Format: Thesis
Language:English
Published: 2020
Subjects:
QC1 Physics (General)
Online Access:http://eprints.usm.my/54982/1/SYLVESTER%20JANDE%20GEMANAM.pdf
http://eprints.usm.my/54982/
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spelling my.usm.eprints.54982 http://eprints.usm.my/54982/ Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser Gemanam, Sylvester Jande QC1 Physics (General) The laser applications on blood helps to elucidates the interaction mechanisms of laser light with blood (biological tissues). The knowledge of blood dielectric response, biostimulation effects and specific absorption rate (SAR) through electrical impedance spectroscopy can optimise appropriate medical therapy without adverse biological alterations. The study used 208 blood samples (128 males and 80 non-pregnant females) from 104 diabetic blood and 104 non-diabetic blood samples collected in ethylenediaminetetra-acetic acid (EDTA) tubes by venepuncture. Each sample was divided into small aliquots such as control (non-irradiated group) and irradiated group samples. The irradiation was carriedout at output powers of 50, 60, 70 and 80 mW for 5, 10, 15 and 20 minutes each using diode-pumped solid-state (DPSS) laser of 532 nm wavelength. Agilent 4294A impedance analyser at frequency range of 40 Hz-30 MHz was used for impedance measurements. Results show significant increased of dielectric parameters (dielectric permittivity, dielectric loss and conductivity) in control in vitro diabetic blood compared with non-diabetic blood. The reduced haemoglobin presence in diabetic blood consequently affects oxygen affinity, reduced cell membrane resistance and induces changes in intrinsic membrane. This effected variation in dipole reactions within cell membranes and conductance transport in the extra-cellular medium to alter the dielectric reactions. Irradiated diabetic blood also showed high significant difference compared to the control counterparts. Dielectric response values; dielectric permittivity, dielectric loss and conductivity were p = 0.003, 0.001 and 0.001 for 10 minutes exposure and p=0.000, 0.005 and 0.004 for 15 minutes exposure respectively at output power of 50 mW. 2020-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/54982/1/SYLVESTER%20JANDE%20GEMANAM.pdf Gemanam, Sylvester Jande (2020) Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser. PhD thesis, Perpustakaan Hamzah Sendut.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic QC1 Physics (General)
spellingShingle QC1 Physics (General)
Gemanam, Sylvester Jande
Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser
description The laser applications on blood helps to elucidates the interaction mechanisms of laser light with blood (biological tissues). The knowledge of blood dielectric response, biostimulation effects and specific absorption rate (SAR) through electrical impedance spectroscopy can optimise appropriate medical therapy without adverse biological alterations. The study used 208 blood samples (128 males and 80 non-pregnant females) from 104 diabetic blood and 104 non-diabetic blood samples collected in ethylenediaminetetra-acetic acid (EDTA) tubes by venepuncture. Each sample was divided into small aliquots such as control (non-irradiated group) and irradiated group samples. The irradiation was carriedout at output powers of 50, 60, 70 and 80 mW for 5, 10, 15 and 20 minutes each using diode-pumped solid-state (DPSS) laser of 532 nm wavelength. Agilent 4294A impedance analyser at frequency range of 40 Hz-30 MHz was used for impedance measurements. Results show significant increased of dielectric parameters (dielectric permittivity, dielectric loss and conductivity) in control in vitro diabetic blood compared with non-diabetic blood. The reduced haemoglobin presence in diabetic blood consequently affects oxygen affinity, reduced cell membrane resistance and induces changes in intrinsic membrane. This effected variation in dipole reactions within cell membranes and conductance transport in the extra-cellular medium to alter the dielectric reactions. Irradiated diabetic blood also showed high significant difference compared to the control counterparts. Dielectric response values; dielectric permittivity, dielectric loss and conductivity were p = 0.003, 0.001 and 0.001 for 10 minutes exposure and p=0.000, 0.005 and 0.004 for 15 minutes exposure respectively at output power of 50 mW.
format Thesis
author Gemanam, Sylvester Jande
author_facet Gemanam, Sylvester Jande
author_sort Gemanam, Sylvester Jande
title Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser
title_short Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser
title_full Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser
title_fullStr Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser
title_full_unstemmed Study Of Dielectric Response And Electrical Impedance Spectroscopy In Diabetic And Non-Diabetic Human Blood Induced By Low Level Laser
title_sort study of dielectric response and electrical impedance spectroscopy in diabetic and non-diabetic human blood induced by low level laser
publishDate 2020
url http://eprints.usm.my/54982/1/SYLVESTER%20JANDE%20GEMANAM.pdf
http://eprints.usm.my/54982/
_version_ 1745563216467984384
score 13.211869

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