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Study on red blood cell alloantibodies detection in malay women during pregnancy

Pregnancy is known to cause red blood cell (RBC) alloimmunisation which may lead to the production of harmful alloantibodies and subsequently potentially to cause haemolytic disease of fetal and newborn (HDFN). However, RBC alloantibodies are significantly different between different populations...

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Main Author: Shah Reza, Johan Noor
Format: Monograph
Language:English
Published: Pusat Pengajian Sains Perubatan 2013
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/54919/1/MADYA%20SHAH%20REZA%20JOHAN%20NOOR%20-%20e.pdf
http://eprints.usm.my/54919/
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spelling my.usm.eprints.54919 http://eprints.usm.my/54919/ Study on red blood cell alloantibodies detection in malay women during pregnancy Shah Reza, Johan Noor R Medicine (General) Pregnancy is known to cause red blood cell (RBC) alloimmunisation which may lead to the production of harmful alloantibodies and subsequently potentially to cause haemolytic disease of fetal and newborn (HDFN). However, RBC alloantibodies are significantly different between different populations and ethnics. Aim of this study is to determine the prevalence of RBC alloantibody among Malay pregnant women and its association with HDFN. Clinical and serological data of 5163 Malay pregnant women who attended labour room, Hospital Universiti Sains Malaysia were collected and analyzed prospectively. The blood samples were subjected to standard blood bank procedure for antibody screening and identification. The infant of women with positive antibody screening was monitored for evidence ofHDFN. Fifty one (0.99%) pregnant women were found to have irregular RBC alloantibodies and when the specificities were further characterized, 30 (0.58%) women were found to possess clinically significant alloantibody. Most of the clinically significant alloantibodies belonged to Rhesus (Rh) system (55.8%) where anti-E (33.3%) was the most common antibody identified, followed by anti-D (10.0%). Fourteen (0.27%) infants were clinically considered to develop HDFN. Anti-D, anti-c and anti-K were identified to cause moderate to severe HDFN. In conclusion, prevalence of RBC alloantibody in Malay pregnant women is low (<1 %), which is similar to other published studies. There were differences in the distribution of alloantibody specificity, however the antibodies toward Rh antigen are still the commonest clinically significant alloantibody identified. Considering the low prevalence of clinically significant alloantibodies and HDFN, the value of current routine antenatal RBC antibody screening practice in most Western countries becomes questionable and may not be directly applicable to Malaysian community without modification. The antibody screen should be restricted to women who are RhD negative, or who have a history of HDFN especially due to anti-c and anti-K. Pusat Pengajian Sains Perubatan 2013 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/54919/1/MADYA%20SHAH%20REZA%20JOHAN%20NOOR%20-%20e.pdf Shah Reza, Johan Noor (2013) Study on red blood cell alloantibodies detection in malay women during pregnancy. Other. Pusat Pengajian Sains Perubatan. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Shah Reza, Johan Noor
Study on red blood cell alloantibodies detection in malay women during pregnancy
description Pregnancy is known to cause red blood cell (RBC) alloimmunisation which may lead to the production of harmful alloantibodies and subsequently potentially to cause haemolytic disease of fetal and newborn (HDFN). However, RBC alloantibodies are significantly different between different populations and ethnics. Aim of this study is to determine the prevalence of RBC alloantibody among Malay pregnant women and its association with HDFN. Clinical and serological data of 5163 Malay pregnant women who attended labour room, Hospital Universiti Sains Malaysia were collected and analyzed prospectively. The blood samples were subjected to standard blood bank procedure for antibody screening and identification. The infant of women with positive antibody screening was monitored for evidence ofHDFN. Fifty one (0.99%) pregnant women were found to have irregular RBC alloantibodies and when the specificities were further characterized, 30 (0.58%) women were found to possess clinically significant alloantibody. Most of the clinically significant alloantibodies belonged to Rhesus (Rh) system (55.8%) where anti-E (33.3%) was the most common antibody identified, followed by anti-D (10.0%). Fourteen (0.27%) infants were clinically considered to develop HDFN. Anti-D, anti-c and anti-K were identified to cause moderate to severe HDFN. In conclusion, prevalence of RBC alloantibody in Malay pregnant women is low (<1 %), which is similar to other published studies. There were differences in the distribution of alloantibody specificity, however the antibodies toward Rh antigen are still the commonest clinically significant alloantibody identified. Considering the low prevalence of clinically significant alloantibodies and HDFN, the value of current routine antenatal RBC antibody screening practice in most Western countries becomes questionable and may not be directly applicable to Malaysian community without modification. The antibody screen should be restricted to women who are RhD negative, or who have a history of HDFN especially due to anti-c and anti-K.
format Monograph
author Shah Reza, Johan Noor
author_facet Shah Reza, Johan Noor
author_sort Shah Reza, Johan Noor
title Study on red blood cell alloantibodies detection in malay women during pregnancy
title_short Study on red blood cell alloantibodies detection in malay women during pregnancy
title_full Study on red blood cell alloantibodies detection in malay women during pregnancy
title_fullStr Study on red blood cell alloantibodies detection in malay women during pregnancy
title_full_unstemmed Study on red blood cell alloantibodies detection in malay women during pregnancy
title_sort study on red blood cell alloantibodies detection in malay women during pregnancy
publisher Pusat Pengajian Sains Perubatan
publishDate 2013
url http://eprints.usm.my/54919/1/MADYA%20SHAH%20REZA%20JOHAN%20NOOR%20-%20e.pdf
http://eprints.usm.my/54919/
_version_ 1745563207721811968
score 13.211869

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