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Studies of transforming growth factor genes in cleft lip and palate in malays population

Cleft lip with or without cleft palate and cleft palate alone are the most common craniofacial anomalies in Malaysia. Causes for clefting to happen are multi-factorial and a number of genes, including the transforming growth factor alpha (TGFa) gene, have been implicated in its etiology. TGFa gen...

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Main Author: Roselinda, Ab Rahman
Format: Monograph
Language:English
Published: Pusat Pengajian Sains Perubatan 2013
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/54825/1/DR.%20ROSELINDA%20AB%20RAHMAN%20-%20e.pdf
http://eprints.usm.my/54825/
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spelling my.usm.eprints.54825 http://eprints.usm.my/54825/ Studies of transforming growth factor genes in cleft lip and palate in malays population Roselinda, Ab Rahman R Medicine (General) Cleft lip with or without cleft palate and cleft palate alone are the most common craniofacial anomalies in Malaysia. Causes for clefting to happen are multi-factorial and a number of genes, including the transforming growth factor alpha (TGFa) gene, have been implicated in its etiology. TGFa gene has been proposed as a candidate genes in the aetiology of nonsyndromic cleft lip and palate based on previous studies on animals (Lee et al 1985, Dixon et al 1991 ). TGFa protein, epidermal growth factor and their receptors were expressed more intensely in regions of developing primary palate where ~ cell proliferation was most pronounced (lamaroon et al 1996). The role of TGFa gene in I lip and palatal development was also confirmed in human allelic association studies • (Ardinger et al 1989, Chevenic-Trench et al 1991, Holder et al 1992). We conducted a study on forty six Malay patients from Kelantan, Malaysia with non-syndromic cleft lip, cleft palate and combination of both cleft and analysed their blood for the (TGFa) gene polymorphism at locus Taq1 and compared it with thirty three control subjects. The results showed no significant difference between patients and controls. The presence of homozygous allele C1C1 was the most common in both cases and control, while ...) homozygous allele C2C2 was absent in both groups. In conclusion, we could not find any association between the TGFa Taq1 gene polymorphism and non-syndromic cleft lip with or without palate Malay patients from Kelantan Malaysia Pusat Pengajian Sains Perubatan 2013 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/54825/1/DR.%20ROSELINDA%20AB%20RAHMAN%20-%20e.pdf Roselinda, Ab Rahman (2013) Studies of transforming growth factor genes in cleft lip and palate in malays population. Other. Pusat Pengajian Sains Perubatan. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Roselinda, Ab Rahman
Studies of transforming growth factor genes in cleft lip and palate in malays population
description Cleft lip with or without cleft palate and cleft palate alone are the most common craniofacial anomalies in Malaysia. Causes for clefting to happen are multi-factorial and a number of genes, including the transforming growth factor alpha (TGFa) gene, have been implicated in its etiology. TGFa gene has been proposed as a candidate genes in the aetiology of nonsyndromic cleft lip and palate based on previous studies on animals (Lee et al 1985, Dixon et al 1991 ). TGFa protein, epidermal growth factor and their receptors were expressed more intensely in regions of developing primary palate where ~ cell proliferation was most pronounced (lamaroon et al 1996). The role of TGFa gene in I lip and palatal development was also confirmed in human allelic association studies • (Ardinger et al 1989, Chevenic-Trench et al 1991, Holder et al 1992). We conducted a study on forty six Malay patients from Kelantan, Malaysia with non-syndromic cleft lip, cleft palate and combination of both cleft and analysed their blood for the (TGFa) gene polymorphism at locus Taq1 and compared it with thirty three control subjects. The results showed no significant difference between patients and controls. The presence of homozygous allele C1C1 was the most common in both cases and control, while ...) homozygous allele C2C2 was absent in both groups. In conclusion, we could not find any association between the TGFa Taq1 gene polymorphism and non-syndromic cleft lip with or without palate Malay patients from Kelantan Malaysia
format Monograph
author Roselinda, Ab Rahman
author_facet Roselinda, Ab Rahman
author_sort Roselinda, Ab Rahman
title Studies of transforming growth factor genes in cleft lip and palate in malays population
title_short Studies of transforming growth factor genes in cleft lip and palate in malays population
title_full Studies of transforming growth factor genes in cleft lip and palate in malays population
title_fullStr Studies of transforming growth factor genes in cleft lip and palate in malays population
title_full_unstemmed Studies of transforming growth factor genes in cleft lip and palate in malays population
title_sort studies of transforming growth factor genes in cleft lip and palate in malays population
publisher Pusat Pengajian Sains Perubatan
publishDate 2013
url http://eprints.usm.my/54825/1/DR.%20ROSELINDA%20AB%20RAHMAN%20-%20e.pdf
http://eprints.usm.my/54825/
_version_ 1744649713896914944
score 13.211869

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