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Annual meeting of the Japanese pharmacological society

High-performance liquid chromatography (HPLC) was compared with gas chromatography-mass spectrometry (GCMS) for determination of morphine in human urine. Calibration standards were prepared In human urine. Codeine and d3-morphine were added as the Internal standards for HPLC and GCMS. respectiv...

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Main Author: Bakar, Ruzilawati Abu
Format: Monograph
Language:English
Published: Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2012
Subjects:
R Medicine
Online Access:http://eprints.usm.my/54762/1/DR%20RUZILAWATI%20ABU%20BAKAR-OCR.pdf
http://eprints.usm.my/54762/
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spelling my.usm.eprints.54762 http://eprints.usm.my/54762/ Annual meeting of the Japanese pharmacological society Bakar, Ruzilawati Abu R Medicine High-performance liquid chromatography (HPLC) was compared with gas chromatography-mass spectrometry (GCMS) for determination of morphine in human urine. Calibration standards were prepared In human urine. Codeine and d3-morphine were added as the Internal standards for HPLC and GCMS. respectively. After solidphase extraction, the reconstituted samples were divided rnto aliquots for analysis br HPLC and GCMS. The analytical performances o the two methods were compared with regard to sensitivity, precision and accuracy. Results Indicated that tfPlC analysis produced results at least as precise, accurate and specific as GCMS for morphrne. Thus, analytical results by HPLC were comparable to GCMS. Therefore. HPLC can be useful alternative to GCMS for measuring morphine in urine. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2012 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/54762/1/DR%20RUZILAWATI%20ABU%20BAKAR-OCR.pdf Bakar, Ruzilawati Abu (2012) Annual meeting of the Japanese pharmacological society. Other. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
spellingShingle R Medicine
Bakar, Ruzilawati Abu
Annual meeting of the Japanese pharmacological society
description High-performance liquid chromatography (HPLC) was compared with gas chromatography-mass spectrometry (GCMS) for determination of morphine in human urine. Calibration standards were prepared In human urine. Codeine and d3-morphine were added as the Internal standards for HPLC and GCMS. respectively. After solidphase extraction, the reconstituted samples were divided rnto aliquots for analysis br HPLC and GCMS. The analytical performances o the two methods were compared with regard to sensitivity, precision and accuracy. Results Indicated that tfPlC analysis produced results at least as precise, accurate and specific as GCMS for morphrne. Thus, analytical results by HPLC were comparable to GCMS. Therefore. HPLC can be useful alternative to GCMS for measuring morphine in urine.
format Monograph
author Bakar, Ruzilawati Abu
author_facet Bakar, Ruzilawati Abu
author_sort Bakar, Ruzilawati Abu
title Annual meeting of the Japanese pharmacological society
title_short Annual meeting of the Japanese pharmacological society
title_full Annual meeting of the Japanese pharmacological society
title_fullStr Annual meeting of the Japanese pharmacological society
title_full_unstemmed Annual meeting of the Japanese pharmacological society
title_sort annual meeting of the japanese pharmacological society
publisher Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
publishDate 2012
url http://eprints.usm.my/54762/1/DR%20RUZILAWATI%20ABU%20BAKAR-OCR.pdf
http://eprints.usm.my/54762/
_version_ 1744649705789325312
score 13.211869

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