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PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study

Curcumin is an antioxidant with various healing properties but possesses limitation due to its poor solubility and reduced bioavailability as pH influences greatly on curcumin. Niosomes are composed of non-ionic surfactants and act as transport vesicle for drug delivery to overcome the limitations...

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Main Author: Kalidas, Saravanan Reddy
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2018
Subjects:
T Technology
TP Chemical Technology
Online Access:http://eprints.usm.my/53969/1/Ph%20Driven%20Encapsulation%20Of%20Curcumin%20In%20Self-Assembled%20Niosome%20Curcuminoid%20Physical%20Characterizations%2C%20Encapsulation%20Efficiency%20%26%20Stability%20Study_Saravanan%20Reddy%20Kalidas_K4_2018.pdf
http://eprints.usm.my/53969/
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spelling my.usm.eprints.53969 http://eprints.usm.my/53969/ PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study Kalidas, Saravanan Reddy T Technology TP Chemical Technology Curcumin is an antioxidant with various healing properties but possesses limitation due to its poor solubility and reduced bioavailability as pH influences greatly on curcumin. Niosomes are composed of non-ionic surfactants and act as transport vesicle for drug delivery to overcome the limitations of curcumin as a potential drug. The aim of this study was to investigate the influence of different pH on the physiochemical properties of curcumin-loaded niosomes. The niosomes were composed of 1:1 mole ratio of Span 60: Tween 60 as vesicle-forming agents and prepared using thin film hydration method. The influence of formulation on vesicle size, entrapment efficiency (EE) and stability of curcumin-loaded niosomes was investigated. Transmission electron microscopy (TEM) revealed that niosomes at pH 3 and 7 had a spherical shape and uniform distribution, while pH 9 produced irregularly shaped niosomes. The results showed that the incorporation of curcumin into niosome at pH 3 yielded vesicles with larger sizes (394.07 ± 17.35 nm to 556.37 ± 28.44 nm) compared to other pH formulation before extrusion. However, after extrusion the size has been significantly reduced to smaller sizes (150.30 ± 2.29 nm to 156.30 ± 2.17 nm). Furthermore, the EE of curcumin niosomes at pH 3 was highest (75.23%) than that of niosomes at pH 7 and 9. The zeta potential at pH 3 was also remarkably lower than pH 7 and 9, yet decreases gradually over time. After 28 days storage, it was found that freezer storage (-4'C) had the highest stability with less reduction in EE. The size of all the formulation increased and started to aggregate when the temperature and storage period increases indicating lower stability at a higher temperature. Universiti Sains Malaysia 2018-06-01 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/53969/1/Ph%20Driven%20Encapsulation%20Of%20Curcumin%20In%20Self-Assembled%20Niosome%20Curcuminoid%20Physical%20Characterizations%2C%20Encapsulation%20Efficiency%20%26%20Stability%20Study_Saravanan%20Reddy%20Kalidas_K4_2018.pdf Kalidas, Saravanan Reddy (2018) PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study. Project Report. Universiti Sains Malaysia, Pusat Pengajian Kejuruteraan Kimia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic T Technology
TP Chemical Technology
spellingShingle T Technology
TP Chemical Technology
Kalidas, Saravanan Reddy
PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study
description Curcumin is an antioxidant with various healing properties but possesses limitation due to its poor solubility and reduced bioavailability as pH influences greatly on curcumin. Niosomes are composed of non-ionic surfactants and act as transport vesicle for drug delivery to overcome the limitations of curcumin as a potential drug. The aim of this study was to investigate the influence of different pH on the physiochemical properties of curcumin-loaded niosomes. The niosomes were composed of 1:1 mole ratio of Span 60: Tween 60 as vesicle-forming agents and prepared using thin film hydration method. The influence of formulation on vesicle size, entrapment efficiency (EE) and stability of curcumin-loaded niosomes was investigated. Transmission electron microscopy (TEM) revealed that niosomes at pH 3 and 7 had a spherical shape and uniform distribution, while pH 9 produced irregularly shaped niosomes. The results showed that the incorporation of curcumin into niosome at pH 3 yielded vesicles with larger sizes (394.07 ± 17.35 nm to 556.37 ± 28.44 nm) compared to other pH formulation before extrusion. However, after extrusion the size has been significantly reduced to smaller sizes (150.30 ± 2.29 nm to 156.30 ± 2.17 nm). Furthermore, the EE of curcumin niosomes at pH 3 was highest (75.23%) than that of niosomes at pH 7 and 9. The zeta potential at pH 3 was also remarkably lower than pH 7 and 9, yet decreases gradually over time. After 28 days storage, it was found that freezer storage (-4'C) had the highest stability with less reduction in EE. The size of all the formulation increased and started to aggregate when the temperature and storage period increases indicating lower stability at a higher temperature.
format Monograph
author Kalidas, Saravanan Reddy
author_facet Kalidas, Saravanan Reddy
author_sort Kalidas, Saravanan Reddy
title PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study
title_short PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study
title_full PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study
title_fullStr PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study
title_full_unstemmed PH Driven Encapsulation Of Curcumin In Self-Assembled Niosome Curcuminoid Physical Characterizations, Encapsulation Efficiency & Stability Study
title_sort ph driven encapsulation of curcumin in self-assembled niosome curcuminoid physical characterizations, encapsulation efficiency & stability study
publisher Universiti Sains Malaysia
publishDate 2018
url http://eprints.usm.my/53969/1/Ph%20Driven%20Encapsulation%20Of%20Curcumin%20In%20Self-Assembled%20Niosome%20Curcuminoid%20Physical%20Characterizations%2C%20Encapsulation%20Efficiency%20%26%20Stability%20Study_Saravanan%20Reddy%20Kalidas_K4_2018.pdf
http://eprints.usm.my/53969/
_version_ 1740826601641213952
score 13.211869

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