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NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011

Objectives: In vitro and in vivo studies have shown involvement of Sema4D, a Class IV semaphorin, in tumor progression. This study aims to characterize the expression of Sema4D in human invasive breast ductal carcinoma and to evaluate its association with pertinent clinicopathological parameters...

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Main Author: Seng, Ch'ng Ewe
Format: Monograph
Language:English
Published: Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2011
Subjects:
R Medicine
Online Access:http://eprints.usm.my/53083/1/DR%20CH%27NG%20EWE%20SENG-Eprints.pdf
http://eprints.usm.my/53083/
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spelling my.usm.eprints.53083 http://eprints.usm.my/53083/ NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011 Seng, Ch'ng Ewe R Medicine Objectives: In vitro and in vivo studies have shown involvement of Sema4D, a Class IV semaphorin, in tumor progression. This study aims to characterize the expression of Sema4D in human invasive breast ductal carcinoma and to evaluate its association with pertinent clinicopathological parameters. Materials and Methods: Expression of Sema4D in 94 patients diagnosed of invasive ductal carcinoma was evaluated immunohistochemically on paraffin-embedded sections. Three best-stained hotspots per case were selected for evaluation employing an intensity distribution score (IDS), a modified Hscore system. Expression was categorized as high or low using median score as cutoff for statistical analysis. Results: Carcinoma cells variably expressed Sema4D. Eighty percent (228/282) of the hotspots coincided with the tumor front. The distribution of IDS of Sema4D expression was skewed (mean 230.32, standard deviation 52.31). No significant association between the levels of expression of Sema4D and age, race, tumor size, tumor grade, number of lymph node metastases, estrogen or progesterone receptor status was observed (p> 0.05). High expression of Sema4D was significantly associated with higher expression of the oncogene, Her-2 (p =0.037). Conclusion: Invasive ductal carcinomas mostly express Sema4D at the tumor front. Sema4D might have prognostic significance as its expression significantly associates with Her·2 expression. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2011 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/53083/1/DR%20CH%27NG%20EWE%20SENG-Eprints.pdf Seng, Ch'ng Ewe (2011) NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011. Other. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
spellingShingle R Medicine
Seng, Ch'ng Ewe
NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011
description Objectives: In vitro and in vivo studies have shown involvement of Sema4D, a Class IV semaphorin, in tumor progression. This study aims to characterize the expression of Sema4D in human invasive breast ductal carcinoma and to evaluate its association with pertinent clinicopathological parameters. Materials and Methods: Expression of Sema4D in 94 patients diagnosed of invasive ductal carcinoma was evaluated immunohistochemically on paraffin-embedded sections. Three best-stained hotspots per case were selected for evaluation employing an intensity distribution score (IDS), a modified Hscore system. Expression was categorized as high or low using median score as cutoff for statistical analysis. Results: Carcinoma cells variably expressed Sema4D. Eighty percent (228/282) of the hotspots coincided with the tumor front. The distribution of IDS of Sema4D expression was skewed (mean 230.32, standard deviation 52.31). No significant association between the levels of expression of Sema4D and age, race, tumor size, tumor grade, number of lymph node metastases, estrogen or progesterone receptor status was observed (p> 0.05). High expression of Sema4D was significantly associated with higher expression of the oncogene, Her-2 (p =0.037). Conclusion: Invasive ductal carcinomas mostly express Sema4D at the tumor front. Sema4D might have prognostic significance as its expression significantly associates with Her·2 expression.
format Monograph
author Seng, Ch'ng Ewe
author_facet Seng, Ch'ng Ewe
author_sort Seng, Ch'ng Ewe
title NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011
title_short NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011
title_full NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011
title_fullStr NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011
title_full_unstemmed NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011
title_sort nuhs-md anderson pathology update singapore 27-29 oktober 2011
publisher Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
publishDate 2011
url http://eprints.usm.my/53083/1/DR%20CH%27NG%20EWE%20SENG-Eprints.pdf
http://eprints.usm.my/53083/
_version_ 1736834800870752256
score 13.211869

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