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Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications

Carbonated Hydroxyapatite (CHA) powder was synthesized via nanoemulsion method and followed by physico-chemical characterizations. The synthesized CHA powder in this study was confirmed that was B-type CHA in calcium deficient. In the second part of the study, the interconnected porous CHA scaffold...

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Main Author: Wong, Shi Chin
Format: Monograph
Language:English
Published: Universiti Sains Malaysia 2018
Subjects:
T Technology
TN Mining Engineering. Metallurgy
Online Access:http://eprints.usm.my/52984/1/Development%20Of%20Carbonated%20Hydroxyapatite%20%28CHA%29%20Porous%20Scaffolds%20For%20Bone%20Tissue%20Engineering%20Applications_Wong%20Shi%20Chin_B1_2018.pdf
http://eprints.usm.my/52984/
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spelling my.usm.eprints.52984 http://eprints.usm.my/52984/ Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications Wong, Shi Chin T Technology TN Mining Engineering. Metallurgy Carbonated Hydroxyapatite (CHA) powder was synthesized via nanoemulsion method and followed by physico-chemical characterizations. The synthesized CHA powder in this study was confirmed that was B-type CHA in calcium deficient. In the second part of the study, the interconnected porous CHA scaffold was fabrication by polyurethane (PU) sponge replica method. The study was to optimize the composition of CHA slurry by manipulating the type of CHA powders as well as the amount of binder and addition of kaolin to have improved the architecture of the scaffold. Sintering was then performed on the CHA scaffolds at 800℃ with two different heating rate of 5℃/min and 10℃/min for 2 hours. 5wt.% kaolin CHA scaffold with binder ratio of PEG: PVA = 2:3 sintered at 800℃ with heating rate of 5℃/min had the most optimum architecture. The optimum scaffold had 80.11% of apparent porosity with about 200-400 μm of macropores, regular thickness of strut with average of 30-50 μm with minimum crack and compressive strength of 0.072 MPa. It can be concluded that the heating rate used in this study showed the least impact in developing the CHA porous scaffolds whereas the key of success in fabrication CHA porous scaffolds in this study is mainly dependent on the compositions of the slurry used. In terms of bioactivity, kaolin CHA scaffold formed apatite layer on the surface of the scaffold after immersed in SBF for 7 days. This showed that kaolin CHA scaffold was suitable to be use in bone tissue engineering especially for non-bearing applications. Universiti Sains Malaysia 2018-06-25 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/52984/1/Development%20Of%20Carbonated%20Hydroxyapatite%20%28CHA%29%20Porous%20Scaffolds%20For%20Bone%20Tissue%20Engineering%20Applications_Wong%20Shi%20Chin_B1_2018.pdf Wong, Shi Chin (2018) Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications. Project Report. Universiti Sains Malaysia, Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic T Technology
TN Mining Engineering. Metallurgy
spellingShingle T Technology
TN Mining Engineering. Metallurgy
Wong, Shi Chin
Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications
description Carbonated Hydroxyapatite (CHA) powder was synthesized via nanoemulsion method and followed by physico-chemical characterizations. The synthesized CHA powder in this study was confirmed that was B-type CHA in calcium deficient. In the second part of the study, the interconnected porous CHA scaffold was fabrication by polyurethane (PU) sponge replica method. The study was to optimize the composition of CHA slurry by manipulating the type of CHA powders as well as the amount of binder and addition of kaolin to have improved the architecture of the scaffold. Sintering was then performed on the CHA scaffolds at 800℃ with two different heating rate of 5℃/min and 10℃/min for 2 hours. 5wt.% kaolin CHA scaffold with binder ratio of PEG: PVA = 2:3 sintered at 800℃ with heating rate of 5℃/min had the most optimum architecture. The optimum scaffold had 80.11% of apparent porosity with about 200-400 μm of macropores, regular thickness of strut with average of 30-50 μm with minimum crack and compressive strength of 0.072 MPa. It can be concluded that the heating rate used in this study showed the least impact in developing the CHA porous scaffolds whereas the key of success in fabrication CHA porous scaffolds in this study is mainly dependent on the compositions of the slurry used. In terms of bioactivity, kaolin CHA scaffold formed apatite layer on the surface of the scaffold after immersed in SBF for 7 days. This showed that kaolin CHA scaffold was suitable to be use in bone tissue engineering especially for non-bearing applications.
format Monograph
author Wong, Shi Chin
author_facet Wong, Shi Chin
author_sort Wong, Shi Chin
title Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications
title_short Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications
title_full Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications
title_fullStr Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications
title_full_unstemmed Development Of Carbonated Hydroxyapatite (CHA) Porous Scaffolds For Bone Tissue Engineering Applications
title_sort development of carbonated hydroxyapatite (cha) porous scaffolds for bone tissue engineering applications
publisher Universiti Sains Malaysia
publishDate 2018
url http://eprints.usm.my/52984/1/Development%20Of%20Carbonated%20Hydroxyapatite%20%28CHA%29%20Porous%20Scaffolds%20For%20Bone%20Tissue%20Engineering%20Applications_Wong%20Shi%20Chin_B1_2018.pdf
http://eprints.usm.my/52984/
_version_ 1736834786108899328
score 13.211869

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