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Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006.

Thalassemia has emerged as one of the most common public health problems in Malaysia, particularly among Malaysian Chinese and Malays. This study aims to determine the spectrum of Thalassaemia gene mutations found in transfusion dependent Thalassaemia patients who attended Pediatric Daycare Unit,...

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Main Author: Rozitah, Razman
Format: Thesis
Language:English
Published: 2008
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/52415/1/DR.%20ROZITAH%20BINTI%20RAZMAN%20-%2024%20pages.pdf
http://eprints.usm.my/52415/
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spelling my.usm.eprints.52415 http://eprints.usm.my/52415/ Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006. Rozitah, Razman R Medicine (General) Thalassemia has emerged as one of the most common public health problems in Malaysia, particularly among Malaysian Chinese and Malays. This study aims to determine the spectrum of Thalassaemia gene mutations found in transfusion dependent Thalassaemia patients who attended Pediatric Daycare Unit, Hospital Universiti Sains Malaysia, Kelantan, Malaysia. The findings are important for establishing the prenatal diagnosis in our Human Genome Centre.This is a cross sectional study in which 38 transfusion dependent Beta Thalassaemia patients were screened for six different mutations previously shown to be prevalent in the Malaysian population. Sampel collection was started in January, 2006 till April, 2006. DNA was extracted from leucocytes collected from the peripheral vein, amplified by PCR and digested by six restriction enzymes for detection of mutations. The mutation were correlated with the clinical severity based on the following clinical parameters : age at presentation, pre-transfusion hemoglobin level, mean volume of blood transfusion per kilo body weight per year, spleen size, spleenectomy and growth failure were recorded in these patients to determine the severity of each group of thalassaemia type depicted by the mutation. For the statistical analysis, Kruskal-Wallis test and univariate analysis were used. 2008 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/52415/1/DR.%20ROZITAH%20BINTI%20RAZMAN%20-%2024%20pages.pdf Rozitah, Razman (2008) Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Rozitah, Razman
Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006.
description Thalassemia has emerged as one of the most common public health problems in Malaysia, particularly among Malaysian Chinese and Malays. This study aims to determine the spectrum of Thalassaemia gene mutations found in transfusion dependent Thalassaemia patients who attended Pediatric Daycare Unit, Hospital Universiti Sains Malaysia, Kelantan, Malaysia. The findings are important for establishing the prenatal diagnosis in our Human Genome Centre.This is a cross sectional study in which 38 transfusion dependent Beta Thalassaemia patients were screened for six different mutations previously shown to be prevalent in the Malaysian population. Sampel collection was started in January, 2006 till April, 2006. DNA was extracted from leucocytes collected from the peripheral vein, amplified by PCR and digested by six restriction enzymes for detection of mutations. The mutation were correlated with the clinical severity based on the following clinical parameters : age at presentation, pre-transfusion hemoglobin level, mean volume of blood transfusion per kilo body weight per year, spleen size, spleenectomy and growth failure were recorded in these patients to determine the severity of each group of thalassaemia type depicted by the mutation. For the statistical analysis, Kruskal-Wallis test and univariate analysis were used.
format Thesis
author Rozitah, Razman
author_facet Rozitah, Razman
author_sort Rozitah, Razman
title Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006.
title_short Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006.
title_full Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006.
title_fullStr Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006.
title_full_unstemmed Molecular study of transfusion dependent thalassemia patients who attended pediatric day care Hospital Universiti Sains Malaysia, Kelantan from January 2006 to April 2006.
title_sort molecular study of transfusion dependent thalassemia patients who attended pediatric day care hospital universiti sains malaysia, kelantan from january 2006 to april 2006.
publishDate 2008
url http://eprints.usm.my/52415/1/DR.%20ROZITAH%20BINTI%20RAZMAN%20-%2024%20pages.pdf
http://eprints.usm.my/52415/
_version_ 1731226364345843712
score 13.211869

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