Cover Image

Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis

Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G. intestinalis. Results showed that Giard1a treated with increased concentration of H20 2 demonstrated significa...

Full description

Saved in:
Bibliographic Details
Main Author: Candy, Chuah
Format: Article
Language:English
Published: Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2019
Subjects:
R Medicine
Online Access:http://eprints.usm.my/51603/1/DR.%20CHUAH%20CANDY-Eprints.pdf
http://eprints.usm.my/51603/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usm.eprints.51603
record_format eprints
spelling my.usm.eprints.51603 http://eprints.usm.my/51603/ Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis Candy, Chuah R Medicine Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G. intestinalis. Results showed that Giard1a treated with increased concentration of H20 2 demonstrated significant reduction in cell viability and significant increase reactive oxygen species production. We found that alpha-2 and alpha-3 giardin showed significant up-regulated transcriptional expression in H,O,-treated Giardia at 1 h time-point, whereas gene expression level of alpha-7.2 and alpha-7.3 giardin up-regulated significantly at 4h time-point Alpha-11 giardin demonstrated up-regulated gene expression at a later time-point (8h and 24h) in H,02- treated Giardia. Together these findings suggest that alpha giardins could serve as potential promising target for future drug design and vaccine development Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2019 Article NonPeerReviewed application/pdf en http://eprints.usm.my/51603/1/DR.%20CHUAH%20CANDY-Eprints.pdf Candy, Chuah (2019) Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis. Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
spellingShingle R Medicine
Candy, Chuah
Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
description Giardiasis is a disease caused by protozoan parasite Giardia intestinalis. Herein, we sought to examine the role of alpha-giardins in response to hydrogen peroxide (H202) treatment in G. intestinalis. Results showed that Giard1a treated with increased concentration of H20 2 demonstrated significant reduction in cell viability and significant increase reactive oxygen species production. We found that alpha-2 and alpha-3 giardin showed significant up-regulated transcriptional expression in H,O,-treated Giardia at 1 h time-point, whereas gene expression level of alpha-7.2 and alpha-7.3 giardin up-regulated significantly at 4h time-point Alpha-11 giardin demonstrated up-regulated gene expression at a later time-point (8h and 24h) in H,02- treated Giardia. Together these findings suggest that alpha giardins could serve as potential promising target for future drug design and vaccine development
format Article
author Candy, Chuah
author_facet Candy, Chuah
author_sort Candy, Chuah
title Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
title_short Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
title_full Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
title_fullStr Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
title_full_unstemmed Elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
title_sort elucidating the roles of annexin-like molecules in the protozoan parasite giardia intestinalis: an approach to the control of giardiasis
publisher Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
publishDate 2019
url http://eprints.usm.my/51603/1/DR.%20CHUAH%20CANDY-Eprints.pdf
http://eprints.usm.my/51603/
_version_ 1725973336045912064
score 13.211869

Similar Items