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Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide

This study aims to elucidate how endothelial dysfunction develops in diabetic • microcirculation. The roles of endothelial derived factors that regulate blood vessel tone and homeostasis: prostacyclin, nitric oxide (NO), endothelium derived hyperpolarizing factors (EDHF) and endothelial prostanoi...

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Main Author: Rasool, Aida Hanum Ghulam
Format: Article
Language:English
Published: Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2019
Subjects:
R Medicine
Online Access:http://eprints.usm.my/51564/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL-Eprints.pdf
http://eprints.usm.my/51564/
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spelling my.usm.eprints.51564 http://eprints.usm.my/51564/ Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide Rasool, Aida Hanum Ghulam R Medicine This study aims to elucidate how endothelial dysfunction develops in diabetic • microcirculation. The roles of endothelial derived factors that regulate blood vessel tone and homeostasis: prostacyclin, nitric oxide (NO), endothelium derived hyperpolarizing factors (EDHF) and endothelial prostanoids were studied in streptozotocin induced diabetic rats. The first part of the project involved In-vitro vascular response studies to determine relative contributions of each endothelial NO, EDHF, prostacyclin and prostanoids mediated relaxation /contraction in normal and diabetic vessels. The second part were biochemical studies (western blot and immunohistochemistry) to determine presence and protein expression of the enzymes and receptors involved in synthesis and action of these factors. These experiments were conducted durin'!l early and late phases of diabetes. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2019 Article NonPeerReviewed application/pdf en http://eprints.usm.my/51564/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL-Eprints.pdf Rasool, Aida Hanum Ghulam (2019) Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide. Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
spellingShingle R Medicine
Rasool, Aida Hanum Ghulam
Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide
description This study aims to elucidate how endothelial dysfunction develops in diabetic • microcirculation. The roles of endothelial derived factors that regulate blood vessel tone and homeostasis: prostacyclin, nitric oxide (NO), endothelium derived hyperpolarizing factors (EDHF) and endothelial prostanoids were studied in streptozotocin induced diabetic rats. The first part of the project involved In-vitro vascular response studies to determine relative contributions of each endothelial NO, EDHF, prostacyclin and prostanoids mediated relaxation /contraction in normal and diabetic vessels. The second part were biochemical studies (western blot and immunohistochemistry) to determine presence and protein expression of the enzymes and receptors involved in synthesis and action of these factors. These experiments were conducted durin'!l early and late phases of diabetes.
format Article
author Rasool, Aida Hanum Ghulam
author_facet Rasool, Aida Hanum Ghulam
author_sort Rasool, Aida Hanum Ghulam
title Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide
title_short Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide
title_full Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide
title_fullStr Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide
title_full_unstemmed Understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide
title_sort understanding development of vasculopathy in diabetic microcirculation - role of endothelial prostanoids, prostacyclin and nitric oxide
publisher Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
publishDate 2019
url http://eprints.usm.my/51564/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL-Eprints.pdf
http://eprints.usm.my/51564/
_version_ 1725973330160254976
score 13.211869

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