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A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM

Retinal hard exudate is a component of diabetic retinopathy which is formed due to breakdown of the inner blood retinal barrier, as a process of microangiopathy. Objectives: To study the association between lipid profile and retinal hard exudates in diabetic retinopathy and the association betwe...

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Main Author: Amelah Mohamed, Abdul Qader
Format: Thesis
Language:English
Published: 2008
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/51548/1/DR.%20AMELAH%20MOHAMED%20ABDUL%20QADER%20-%2024%20pages.pdf
http://eprints.usm.my/51548/
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spelling my.usm.eprints.51548 http://eprints.usm.my/51548/ A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM Amelah Mohamed, Abdul Qader R Medicine (General) Retinal hard exudate is a component of diabetic retinopathy which is formed due to breakdown of the inner blood retinal barrier, as a process of microangiopathy. Objectives: To study the association between lipid profile and retinal hard exudates in diabetic retinopathy and the association between oxidized-LDL with systemic diseases among type 2 diabetic patients. Methodology: A cross sectional study was conducted in 40 patients with diabetic retinopathy and another 40 patients without diabetic retinopathy. Demographic data was collected and comprehensive ocular examination was performed. Nine ml venous blood was taken for fasting serum cholesterol, triglycerides, HDL, LDL, ox-LDL, and for HbAIC· Results: The mean serum cholesterol level was 5.9 (1.86) mmol/L in diabetic retinopathy group compared to patients without retinopathy 5.0 (1.03) mmoi/L (P= 0.001). The mean serum LDL was 3.6 (1.69) mmol/L in retinopathy group compared to 3.0 (1.02) mmoi!L in the contol group (P=0.005). There was a higher concentration of serum cholesterol, triglyceride and LDL in patients with severe retinal hard exudates compared to those with mild and moderate,however it was not statistically significant (P= 0.082, 0.116, 0.218) respectively. The mean serum oxidized-LDL concentration was higher in diabetic retinopathy with severe retinal hard exudates compared to mild and xi moderate. There was no statistically significant difference in the mean oxidized LDL with other systemic diseases or duration of diabetes. Conelusion: There was significant association between serum cholesterol and LDL with diabetic retinopathy. However there was no association between serum lipid profile with the severity of retinal hard exudates. Serum ox-LDL was also not associated with diabetic retinopathy and other systemic co-morbidities in our study. 2008 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/51548/1/DR.%20AMELAH%20MOHAMED%20ABDUL%20QADER%20-%2024%20pages.pdf Amelah Mohamed, Abdul Qader (2008) A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Amelah Mohamed, Abdul Qader
A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM
description Retinal hard exudate is a component of diabetic retinopathy which is formed due to breakdown of the inner blood retinal barrier, as a process of microangiopathy. Objectives: To study the association between lipid profile and retinal hard exudates in diabetic retinopathy and the association between oxidized-LDL with systemic diseases among type 2 diabetic patients. Methodology: A cross sectional study was conducted in 40 patients with diabetic retinopathy and another 40 patients without diabetic retinopathy. Demographic data was collected and comprehensive ocular examination was performed. Nine ml venous blood was taken for fasting serum cholesterol, triglycerides, HDL, LDL, ox-LDL, and for HbAIC· Results: The mean serum cholesterol level was 5.9 (1.86) mmol/L in diabetic retinopathy group compared to patients without retinopathy 5.0 (1.03) mmoi/L (P= 0.001). The mean serum LDL was 3.6 (1.69) mmol/L in retinopathy group compared to 3.0 (1.02) mmoi!L in the contol group (P=0.005). There was a higher concentration of serum cholesterol, triglyceride and LDL in patients with severe retinal hard exudates compared to those with mild and moderate,however it was not statistically significant (P= 0.082, 0.116, 0.218) respectively. The mean serum oxidized-LDL concentration was higher in diabetic retinopathy with severe retinal hard exudates compared to mild and xi moderate. There was no statistically significant difference in the mean oxidized LDL with other systemic diseases or duration of diabetes. Conelusion: There was significant association between serum cholesterol and LDL with diabetic retinopathy. However there was no association between serum lipid profile with the severity of retinal hard exudates. Serum ox-LDL was also not associated with diabetic retinopathy and other systemic co-morbidities in our study.
format Thesis
author Amelah Mohamed, Abdul Qader
author_facet Amelah Mohamed, Abdul Qader
author_sort Amelah Mohamed, Abdul Qader
title A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM
title_short A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM
title_full A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM
title_fullStr A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM
title_full_unstemmed A study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in Hospital USM
title_sort study on the association of serum lipid profile with retinal hard exudates among patients wim type 2 diabetes mellitus in hospital usm
publishDate 2008
url http://eprints.usm.my/51548/1/DR.%20AMELAH%20MOHAMED%20ABDUL%20QADER%20-%2024%20pages.pdf
http://eprints.usm.my/51548/
_version_ 1725973327731752960
score 13.211869

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