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Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective

Aim: This study was performed to measure psychological problems in children with idiopathic nephrotic syndrome (INS) when they are on steroid therapy compared to healthy children. Methods: It was a prospective cohort study conducted at a paediatric clinic in a tertiary hospital. The parents of part...

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Main Author: Mahmud, Mohamad Nizam
Format: Thesis
Language:English
Published: 2020
Subjects:
R Medicine
Online Access:http://eprints.usm.my/50235/1/Mohamad%20Nizam%20Mahmud-24%20pages.pdf
http://eprints.usm.my/50235/
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spelling my.usm.eprints.50235 http://eprints.usm.my/50235/ Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective Mahmud, Mohamad Nizam R Medicine Aim: This study was performed to measure psychological problems in children with idiopathic nephrotic syndrome (INS) when they are on steroid therapy compared to healthy children. Methods: It was a prospective cohort study conducted at a paediatric clinic in a tertiary hospital. The parents of participants in both the INS and control groups comprising of children without chronic illness were asked to complete questionnaires using the Child Behavioural Checklist (CBCL). CBCL measures a range of age-specific emotional and psychological problems, including Internalising and Externalising domains. Analyses of the CBCL scores between the groups were performed using the Mann–Whitney test. Results: A total of 140 children were recruited with equal numbers in the INS and control groups. There was a significant difference in the mean total CBCL scores between the INS and control groups, specifically in the withdrawal, somatic, anxious and aggressiveness sub-domains. Similar findings were demonstrated in the correlation between total psychological problems and corticosteroid dosage. In the INS group, steroid dose and cushingoid features were found to have a significant positive association with internalising psychological problems. Likewise, steroid dose and age were significantly associated with externalising scores. Conclusion: Children with INS on corticosteroid therapy showed an increase in internalising and externalising scores compared to healthy children. 2020 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/50235/1/Mohamad%20Nizam%20Mahmud-24%20pages.pdf Mahmud, Mohamad Nizam (2020) Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
spellingShingle R Medicine
Mahmud, Mohamad Nizam
Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
description Aim: This study was performed to measure psychological problems in children with idiopathic nephrotic syndrome (INS) when they are on steroid therapy compared to healthy children. Methods: It was a prospective cohort study conducted at a paediatric clinic in a tertiary hospital. The parents of participants in both the INS and control groups comprising of children without chronic illness were asked to complete questionnaires using the Child Behavioural Checklist (CBCL). CBCL measures a range of age-specific emotional and psychological problems, including Internalising and Externalising domains. Analyses of the CBCL scores between the groups were performed using the Mann–Whitney test. Results: A total of 140 children were recruited with equal numbers in the INS and control groups. There was a significant difference in the mean total CBCL scores between the INS and control groups, specifically in the withdrawal, somatic, anxious and aggressiveness sub-domains. Similar findings were demonstrated in the correlation between total psychological problems and corticosteroid dosage. In the INS group, steroid dose and cushingoid features were found to have a significant positive association with internalising psychological problems. Likewise, steroid dose and age were significantly associated with externalising scores. Conclusion: Children with INS on corticosteroid therapy showed an increase in internalising and externalising scores compared to healthy children.
format Thesis
author Mahmud, Mohamad Nizam
author_facet Mahmud, Mohamad Nizam
author_sort Mahmud, Mohamad Nizam
title Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_short Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_full Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_fullStr Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_full_unstemmed Increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a South Est Asian perspective
title_sort increased internalising and externalising behavioural problems associated with corticosteroid usage in children with nephrotic syndrome : a south est asian perspective
publishDate 2020
url http://eprints.usm.my/50235/1/Mohamad%20Nizam%20Mahmud-24%20pages.pdf
http://eprints.usm.my/50235/
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score 13.211869

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