Cover Image

Forensic determination of drug tablets upon external exposures

Pharmaceutical tablet is a prescription dosage type that includes the active component of the medication material with the suitable diluents. Exposure of drugs to environmental factors, such as moisture, heat and stress, might deteriorate the product as well as change the physicochemical properties...

Full description

Saved in:
Bibliographic Details
Main Author: Sufri, Noorshuhaida Muhamad
Format: Thesis
Language:English
Published: 2020
Subjects:
R Medicine
Online Access:http://eprints.usm.my/49094/1/TESIS-NOORSHUHAIDA%20MUHAMAD%20SUFRI%20%28P-SKM0048_19%29-24%20pages.pdf
http://eprints.usm.my/49094/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.usm.eprints.49094
record_format eprints
spelling my.usm.eprints.49094 http://eprints.usm.my/49094/ Forensic determination of drug tablets upon external exposures Sufri, Noorshuhaida Muhamad R Medicine Pharmaceutical tablet is a prescription dosage type that includes the active component of the medication material with the suitable diluents. Exposure of drugs to environmental factors, such as moisture, heat and stress, might deteriorate the product as well as change the physicochemical properties of the drug. Such changes might also influence the safety and effectiveness of the medication tablet. This study was aimed to investigate the effect of environmental exposure on drug tablets. In this study, the samples were insulted with different condition and contaminants including closed, temperature, water, acid, base and oil. The samples were then exposed for the duration one week and one month. After the exposure duration end, physical examination was conducted to examine the physical changes that occur to the tablets. Samples profiles were generated through attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) analysis. The ATR-FTIR data was also decomposed by Principal Component Analysis (PCA) to distinguish the drug tablet samples based on the environmental exposures. Although subjected to environmental exposures, the ATR-FTIR profiles appeared very similar among the samples, as paracetamol is the main ingredient of the tablet. Since PCA did not showed significant discrimination with different environmental exposure, Discrimination Analysis (DA) was conducted to create better visualization and differentiation among the samples. DA results demonstrated that Panadol for Children and Panadol Soluble had achieved 100% correctly clustering. Additionally, Panadol-650 had reached up to 88.9% accurate classification. Other samples including Paracil (SM), Paracil (Mal), Panadol Menstrual, Uphamol-650 and Febricol-RX were hardly to be distinguished. In conclusion, physical observation was more suited in discrimination of tableted drug as compared to chemical analysis. External insults were found not to introduce any impact in the physical and chemical characteristics on the drugs tested in this study. 2020-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/49094/1/TESIS-NOORSHUHAIDA%20MUHAMAD%20SUFRI%20%28P-SKM0048_19%29-24%20pages.pdf Sufri, Noorshuhaida Muhamad (2020) Forensic determination of drug tablets upon external exposures. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
spellingShingle R Medicine
Sufri, Noorshuhaida Muhamad
Forensic determination of drug tablets upon external exposures
description Pharmaceutical tablet is a prescription dosage type that includes the active component of the medication material with the suitable diluents. Exposure of drugs to environmental factors, such as moisture, heat and stress, might deteriorate the product as well as change the physicochemical properties of the drug. Such changes might also influence the safety and effectiveness of the medication tablet. This study was aimed to investigate the effect of environmental exposure on drug tablets. In this study, the samples were insulted with different condition and contaminants including closed, temperature, water, acid, base and oil. The samples were then exposed for the duration one week and one month. After the exposure duration end, physical examination was conducted to examine the physical changes that occur to the tablets. Samples profiles were generated through attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) analysis. The ATR-FTIR data was also decomposed by Principal Component Analysis (PCA) to distinguish the drug tablet samples based on the environmental exposures. Although subjected to environmental exposures, the ATR-FTIR profiles appeared very similar among the samples, as paracetamol is the main ingredient of the tablet. Since PCA did not showed significant discrimination with different environmental exposure, Discrimination Analysis (DA) was conducted to create better visualization and differentiation among the samples. DA results demonstrated that Panadol for Children and Panadol Soluble had achieved 100% correctly clustering. Additionally, Panadol-650 had reached up to 88.9% accurate classification. Other samples including Paracil (SM), Paracil (Mal), Panadol Menstrual, Uphamol-650 and Febricol-RX were hardly to be distinguished. In conclusion, physical observation was more suited in discrimination of tableted drug as compared to chemical analysis. External insults were found not to introduce any impact in the physical and chemical characteristics on the drugs tested in this study.
format Thesis
author Sufri, Noorshuhaida Muhamad
author_facet Sufri, Noorshuhaida Muhamad
author_sort Sufri, Noorshuhaida Muhamad
title Forensic determination of drug tablets upon external exposures
title_short Forensic determination of drug tablets upon external exposures
title_full Forensic determination of drug tablets upon external exposures
title_fullStr Forensic determination of drug tablets upon external exposures
title_full_unstemmed Forensic determination of drug tablets upon external exposures
title_sort forensic determination of drug tablets upon external exposures
publishDate 2020
url http://eprints.usm.my/49094/1/TESIS-NOORSHUHAIDA%20MUHAMAD%20SUFRI%20%28P-SKM0048_19%29-24%20pages.pdf
http://eprints.usm.my/49094/
_version_ 1699238018184904704
score 13.211869

Similar Items