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Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women

Depletion of estrogen production and secretion in postmenopausal women may lead to rapid bone loss and decreased bone mineral density (BMD). Decreased systemic BMD may also affect oral bone particularly mandibular bone resorption. Although several environmental factors influence bone loss, geneti...

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Main Author: Rehman, Asia
Format: Monograph
Language:English
Published: Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia 2006
Subjects:
R Medicine
Online Access:http://eprints.usm.my/47879/1/DR.%20ASIA%20REHMAN-Abstract.pdf
http://eprints.usm.my/47879/
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spelling my.usm.eprints.47879 http://eprints.usm.my/47879/ Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women Rehman, Asia R Medicine Depletion of estrogen production and secretion in postmenopausal women may lead to rapid bone loss and decreased bone mineral density (BMD). Decreased systemic BMD may also affect oral bone particularly mandibular bone resorption. Although several environmental factors influence bone loss, genetic contribution particularly estrogen receptor gene (ERG) polymorphism had been reported. The objectives of this study were to investigate the distribution of ERG polymorphisms in postmenopausal Malay women (PMW) and to detect the association of the polymorphisms to alveolar bone resorption. Sixty four PMW were recruited from the Out Patient Dental Clinic, Hospital Universiti Sains Malaysia, Kelantan. Oral examination and alveolar bone resorption measurement were performed on these study subjects. Genotyping was done through the restriction cleavage of polymerase chain reactionamplified genomic DNA with the two restriction enzymes, Pvull and Xbal. Estrogen receptor genotypes were represented as P or p (Pvull) and X or x (Xbal) with the lower case letters signifying the presence of the restriction site. The results of this study indicated a high frequency of heterozygous allelic variant (PpXx) in PMW. However no significant association between ERG polymorphisms and alveolar bone resorption was observed. Therefore ERG polymorphisms may not be a genetic marker for the alveolar bone resorption in PMW. Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia 2006 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/47879/1/DR.%20ASIA%20REHMAN-Abstract.pdf Rehman, Asia (2006) Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women. Documentation. Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia. (Submitted)
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine
spellingShingle R Medicine
Rehman, Asia
Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
description Depletion of estrogen production and secretion in postmenopausal women may lead to rapid bone loss and decreased bone mineral density (BMD). Decreased systemic BMD may also affect oral bone particularly mandibular bone resorption. Although several environmental factors influence bone loss, genetic contribution particularly estrogen receptor gene (ERG) polymorphism had been reported. The objectives of this study were to investigate the distribution of ERG polymorphisms in postmenopausal Malay women (PMW) and to detect the association of the polymorphisms to alveolar bone resorption. Sixty four PMW were recruited from the Out Patient Dental Clinic, Hospital Universiti Sains Malaysia, Kelantan. Oral examination and alveolar bone resorption measurement were performed on these study subjects. Genotyping was done through the restriction cleavage of polymerase chain reactionamplified genomic DNA with the two restriction enzymes, Pvull and Xbal. Estrogen receptor genotypes were represented as P or p (Pvull) and X or x (Xbal) with the lower case letters signifying the presence of the restriction site. The results of this study indicated a high frequency of heterozygous allelic variant (PpXx) in PMW. However no significant association between ERG polymorphisms and alveolar bone resorption was observed. Therefore ERG polymorphisms may not be a genetic marker for the alveolar bone resorption in PMW.
format Monograph
author Rehman, Asia
author_facet Rehman, Asia
author_sort Rehman, Asia
title Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_short Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_full Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_fullStr Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_full_unstemmed Studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
title_sort studies to investigate the prevalence of estrogen receptor polymorphism & its association alveolar bone loss & early tooth loss in postmenopausal women
publisher Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia
publishDate 2006
url http://eprints.usm.my/47879/1/DR.%20ASIA%20REHMAN-Abstract.pdf
http://eprints.usm.my/47879/
_version_ 1683231620531748864
score 13.211869

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