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Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice

Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of...

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Main Author: Kumar, Venugopalan Santhosh
Format: Thesis
Language:English
Published: 2018
Subjects:
QR Microbiology
Online Access:http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf
http://eprints.usm.my/47797/
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spelling my.usm.eprints.47797 http://eprints.usm.my/47797/ Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice Kumar, Venugopalan Santhosh QR Microbiology Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity. 2018-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf Kumar, Venugopalan Santhosh (2018) Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice. PhD thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic QR Microbiology
spellingShingle QR Microbiology
Kumar, Venugopalan Santhosh
Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
description Present study was aimed to evaluate the potential immunostimulant activity of NAcetylglucosamine (NAG) from Azadirachta indica leaves in mice. The hexane, chloroform, methanol and aqueous extracts of A. indica leaves were prepared and its immunostimulant activity was studied. The aqueous extract of A. indica leaves (AEAIL) showed significant (P< 0.001) higher immunostimulant activity than other extracts. Hence, isolation of possible phytoconstituent(s) from AEAIL was carried out and the N-Acetylglucosamine (NAG) was isolated. The NAG was administered at 266, 400 and 800 μg/kg of mice, intraperitoneal route weekly for 4 weeks to evaluate immunostimulant activity.
format Thesis
author Kumar, Venugopalan Santhosh
author_facet Kumar, Venugopalan Santhosh
author_sort Kumar, Venugopalan Santhosh
title Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_short Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_full Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_fullStr Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_full_unstemmed Potential Immunomodulating Activity Of Neem (Azadirachta Indica) Leaf Extracts And Its Bioactive Compound N-Acetylglucosamine In Mice
title_sort potential immunomodulating activity of neem (azadirachta indica) leaf extracts and its bioactive compound n-acetylglucosamine in mice
publishDate 2018
url http://eprints.usm.my/47797/1/POTENTIAL%20IMMUNOMODULATING.pdf%20cut.pdf
http://eprints.usm.my/47797/
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score 13.211869

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