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Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan

Background: There is no optilnmn level or threshold that has been clearly established to define whether there is adequate store of vitamin D in the body for general bone health. Therefore, our study is to determine the optimum level of vitamin D for maintenance of healthy skeleton based on bone remo...

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Main Author: Muda, Noor Bayani Che
Format: Thesis
Language:English
Published: 2017
Subjects:
RC Internal medicine
Online Access:http://eprints.usm.my/46901/1/Dr.%20Noor%20Bayani%20Che%20Muda-24%20pages.pdf
http://eprints.usm.my/46901/
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spelling my.usm.eprints.46901 http://eprints.usm.my/46901/ Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan Muda, Noor Bayani Che RC Internal medicine Background: There is no optilnmn level or threshold that has been clearly established to define whether there is adequate store of vitamin D in the body for general bone health. Therefore, our study is to determine the optimum level of vitamin D for maintenance of healthy skeleton based on bone remodelling process. Methods: This was a cross sectional study involving healthy adult population in Kota Bharu, Malaysia, aged 18-50 years. We measured serwn 25(0H)D, serum parathyroid hormone (PTH), serum C-terminal telopeptide of type 1 collagen ( CTX) and Procollagen 1 Intact N-Terminal (P1NP) in 120 healthy adult from 6 sub districts that had been selected by multi stage sampling ( 64 males, 56 females). Results: The mean of vitamin Din this study was 23.50 (±8.74) nmol/L and there was significant difference of vitamin D betvveen gender (26.81±8.3 nmol/L and 19.72±7.68 nmol/L males and females respectively), p value < 0.001. More than 50% of female subjects had vitamin D less than 20 nmol/L, while only 20.3% of male subjects had vitamin D below 20 nmol/L. Based on LOESS plot, the bone turnover markers showed plateau result at vitamin D level of 3 5 nmoi!L for CTX and 20 nmoi/L for p 1 NP. Then, at vitamin D level of 20 nmol/L there is a step decrease of PTH level. Conclusion: The mean of vitamin D among general healthy population in Kota Bharu was 23.50nmoi/L. Based on inspection of LOESS plot for CTX, PlNP and PTH versusvitamin D level, we concluded that vitamin D level between 20 nmol/L to 35 nmol/L is considered sufficient to maintain healthy skeleton. 2017 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46901/1/Dr.%20Noor%20Bayani%20Che%20Muda-24%20pages.pdf Muda, Noor Bayani Che (2017) Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC Internal medicine
spellingShingle RC Internal medicine
Muda, Noor Bayani Che
Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
description Background: There is no optilnmn level or threshold that has been clearly established to define whether there is adequate store of vitamin D in the body for general bone health. Therefore, our study is to determine the optimum level of vitamin D for maintenance of healthy skeleton based on bone remodelling process. Methods: This was a cross sectional study involving healthy adult population in Kota Bharu, Malaysia, aged 18-50 years. We measured serwn 25(0H)D, serum parathyroid hormone (PTH), serum C-terminal telopeptide of type 1 collagen ( CTX) and Procollagen 1 Intact N-Terminal (P1NP) in 120 healthy adult from 6 sub districts that had been selected by multi stage sampling ( 64 males, 56 females). Results: The mean of vitamin Din this study was 23.50 (±8.74) nmol/L and there was significant difference of vitamin D betvveen gender (26.81±8.3 nmol/L and 19.72±7.68 nmol/L males and females respectively), p value < 0.001. More than 50% of female subjects had vitamin D less than 20 nmol/L, while only 20.3% of male subjects had vitamin D below 20 nmol/L. Based on LOESS plot, the bone turnover markers showed plateau result at vitamin D level of 3 5 nmoi!L for CTX and 20 nmoi/L for p 1 NP. Then, at vitamin D level of 20 nmol/L there is a step decrease of PTH level. Conclusion: The mean of vitamin D among general healthy population in Kota Bharu was 23.50nmoi/L. Based on inspection of LOESS plot for CTX, PlNP and PTH versusvitamin D level, we concluded that vitamin D level between 20 nmol/L to 35 nmol/L is considered sufficient to maintain healthy skeleton.
format Thesis
author Muda, Noor Bayani Che
author_facet Muda, Noor Bayani Che
author_sort Muda, Noor Bayani Che
title Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
title_short Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
title_full Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
title_fullStr Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
title_full_unstemmed Study on vitamin D status and determination of optimum vitamin D level based on bone turnover markers in Kota Bharu, Kelantan
title_sort study on vitamin d status and determination of optimum vitamin d level based on bone turnover markers in kota bharu, kelantan
publishDate 2017
url http://eprints.usm.my/46901/1/Dr.%20Noor%20Bayani%20Che%20Muda-24%20pages.pdf
http://eprints.usm.my/46901/
_version_ 1677781999218065408
score 13.211869

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