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Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter

Background Non erosive reflux Disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD).It may potentially represent the most common manifestation of reflux disease. Although numerous studies had been performed on NERD,none of the the studies had explor...

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Main Author: Azis, Nazihah
Format: Thesis
Language:English
Published: 2018
Subjects:
RC799-869 Diseases of the digestive system. Gastroenterology
Online Access:http://eprints.usm.my/46691/1/Dr.%20Nazihah%20Azis-24%20pages.pdf
http://eprints.usm.my/46691/
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spelling my.usm.eprints.46691 http://eprints.usm.my/46691/ Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter Azis, Nazihah RC799-869 Diseases of the digestive system. Gastroenterology Background Non erosive reflux Disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD).It may potentially represent the most common manifestation of reflux disease. Although numerous studies had been performed on NERD,none of the the studies had explored the expression of TRPV4 as a causative factor and the link between pH study and manometry. This knowledge is beneficial for new targeted treatment. Methodology This was a prospective study that was done on NERD and control patients from March 2017 until November 2017. A total of 55 patients - 39 NERD and 16 control patients were investigated. All patients had undergone EGD and multiple biopsies were taken. Notably, erosive esophagitis patients were excluded. Apart from that, the patients also went through pH study and manometry. Results The result from this research we showed that TRPV4 was expressed in both NERD and control patients. No association was discovered between TRPV4 and NERD, as well as among pH study, manometry and endoscopic features. Futhermore, TRPV4 was found to be higher in cells from the normal group as compared to the NERD group. Notably, p-value was insignificant but this may be caused by small sample size Conclusion This study was performed to determine the association between TRPV4 and NERD. No significant association was revealed between the expression of of TRPV 4 and the NERD group. Similarly, other parameters from pH study, manometry and endoscopic finding also did not show any significant association with TRPV4. 2018 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46691/1/Dr.%20Nazihah%20Azis-24%20pages.pdf Azis, Nazihah (2018) Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RC799-869 Diseases of the digestive system. Gastroenterology
spellingShingle RC799-869 Diseases of the digestive system. Gastroenterology
Azis, Nazihah
Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
description Background Non erosive reflux Disease (NERD) has emerged as a real entity in the spectrum of gastroesophageal reflux disease (GERD).It may potentially represent the most common manifestation of reflux disease. Although numerous studies had been performed on NERD,none of the the studies had explored the expression of TRPV4 as a causative factor and the link between pH study and manometry. This knowledge is beneficial for new targeted treatment. Methodology This was a prospective study that was done on NERD and control patients from March 2017 until November 2017. A total of 55 patients - 39 NERD and 16 control patients were investigated. All patients had undergone EGD and multiple biopsies were taken. Notably, erosive esophagitis patients were excluded. Apart from that, the patients also went through pH study and manometry. Results The result from this research we showed that TRPV4 was expressed in both NERD and control patients. No association was discovered between TRPV4 and NERD, as well as among pH study, manometry and endoscopic features. Futhermore, TRPV4 was found to be higher in cells from the normal group as compared to the NERD group. Notably, p-value was insignificant but this may be caused by small sample size Conclusion This study was performed to determine the association between TRPV4 and NERD. No significant association was revealed between the expression of of TRPV 4 and the NERD group. Similarly, other parameters from pH study, manometry and endoscopic finding also did not show any significant association with TRPV4.
format Thesis
author Azis, Nazihah
author_facet Azis, Nazihah
author_sort Azis, Nazihah
title Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_short Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_full Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_fullStr Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_full_unstemmed Expression of transient receptor potential vanilloid 4 (TRPV4) in NERD vs normal control and association with PH study and manometry parameter
title_sort expression of transient receptor potential vanilloid 4 (trpv4) in nerd vs normal control and association with ph study and manometry parameter
publishDate 2018
url http://eprints.usm.my/46691/1/Dr.%20Nazihah%20Azis-24%20pages.pdf
http://eprints.usm.my/46691/
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score 13.211869

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