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Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients

Advances in radiotherapy technology has made it possible to deliver highly conformal Intensity Modulated Radiotherapy (IMRT) beam to treat patient with improved setup accuracy using Image Guided Radiotherapy (IGRT). This retrospective study investigates the accuracy of IG-IMRT treatment for 25 head...

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Main Author: M Zamri, Nada' Alia
Format: Thesis
Language:English
Published: 2019
Subjects:
R Medicine (General)
Online Access:http://eprints.usm.my/46407/1/NADA%20%E2%80%98ALIA%20BINTI%20M%20ZAMRI_HJ.pdf
http://eprints.usm.my/46407/
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spelling my.usm.eprints.46407 http://eprints.usm.my/46407/ Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients M Zamri, Nada' Alia R Medicine (General) Advances in radiotherapy technology has made it possible to deliver highly conformal Intensity Modulated Radiotherapy (IMRT) beam to treat patient with improved setup accuracy using Image Guided Radiotherapy (IGRT). This retrospective study investigates the accuracy of IG-IMRT treatment for 25 head and neck cancer (HNC) patients in Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia. An ionisation chamber array detector has been characterised and used for patient specific IMRT QA. The characterisation study shows the doses measured using ionisation chamber array detector were within 2% compared with the doses calculated from the treatment planning system (TPS). All 25 IMRT treatment obtained percentage pass rate ≥95% when 3%/3 mm gamma criteria were used. The geometrical accuracy of the treatment was also analysed based on setup errors measured using kV cone beam CT based-IGRT. A total of 231 pre-treatment CBCT imaging were acquired prior to treatment and compared to the reference CT. PTV margin of ≥3 mm in RL direction, SI direction and AP direction is required if no setup correction was performed. Offline setup protocols; NAL and eNAL were simulated on the setup errors recorded. The eNAL protocol recorded the smallest setup error in all three directions; which were 1.59 mm for RL direction, 2.13 mm for SI direction and 1.61 mm for AP direction. The impact of setup errors on dose distributions was also assessed on six HNC patients. 2019-07 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46407/1/NADA%20%E2%80%98ALIA%20BINTI%20M%20ZAMRI_HJ.pdf M Zamri, Nada' Alia (2019) Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
M Zamri, Nada' Alia
Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients
description Advances in radiotherapy technology has made it possible to deliver highly conformal Intensity Modulated Radiotherapy (IMRT) beam to treat patient with improved setup accuracy using Image Guided Radiotherapy (IGRT). This retrospective study investigates the accuracy of IG-IMRT treatment for 25 head and neck cancer (HNC) patients in Advanced Medical & Dental Institute (AMDI), Universiti Sains Malaysia. An ionisation chamber array detector has been characterised and used for patient specific IMRT QA. The characterisation study shows the doses measured using ionisation chamber array detector were within 2% compared with the doses calculated from the treatment planning system (TPS). All 25 IMRT treatment obtained percentage pass rate ≥95% when 3%/3 mm gamma criteria were used. The geometrical accuracy of the treatment was also analysed based on setup errors measured using kV cone beam CT based-IGRT. A total of 231 pre-treatment CBCT imaging were acquired prior to treatment and compared to the reference CT. PTV margin of ≥3 mm in RL direction, SI direction and AP direction is required if no setup correction was performed. Offline setup protocols; NAL and eNAL were simulated on the setup errors recorded. The eNAL protocol recorded the smallest setup error in all three directions; which were 1.59 mm for RL direction, 2.13 mm for SI direction and 1.61 mm for AP direction. The impact of setup errors on dose distributions was also assessed on six HNC patients.
format Thesis
author M Zamri, Nada' Alia
author_facet M Zamri, Nada' Alia
author_sort M Zamri, Nada' Alia
title Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients
title_short Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients
title_full Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients
title_fullStr Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients
title_full_unstemmed Dosimetric And Geometric Accuracy Of Image Guided Intensity Modulated Radiotherapy (IG-IMRT) In Head And Neck Cancer Patients
title_sort dosimetric and geometric accuracy of image guided intensity modulated radiotherapy (ig-imrt) in head and neck cancer patients
publishDate 2019
url http://eprints.usm.my/46407/1/NADA%20%E2%80%98ALIA%20BINTI%20M%20ZAMRI_HJ.pdf
http://eprints.usm.my/46407/
_version_ 1662755780334452736
score 13.211869

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